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Study · In vitro (cells) · bovine · 1996

5 results

Differential effects of oxytocin on steroid production by bovine granulosa cells.

Berndtson AK, Weaver CJ, Fortune JE

Molecular and cellular endocrinology1 Feb 1996Cited by 20 (Europe PMC)

PMID8647319 (opens in a new tab)DOI10.1016/0303-7207(95)03714-4 (opens in a new tab)PepBankPUB-08647319
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In bovine granulosa cell cultures, oxytocin stimulated progesterone production in both control and FSH-treated cultures.

    In plain wordsIn cultured cow ovary cells, oxytocin increased progesterone production.

    Peptide
    Oxytocin
    Outcome
    IncreaseProgesterone production
    Study

    bovinen: not reported in source

    granulosa cells from bovine preovulatory follicles
    Comparator
    Culture without oxytocin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    P value
    < 0.01
    progesterone

    Source sentences

    Summary
    OT stimulated progesterone (P < 0.01)
    1 context sentence
    Summary · context
    Granulosa cells were isolated from bovine preovulatory follicles and cultured for 3 days with or without OT in medium supplemented with either insulin (1 microgram/ml) + 1% fetal calf serum (FCS), which maintains basal estradiol secretion, or low doses of FSH (1 and 2 ng/ml) + 1% FCS, a culture cond…
  2. 02LabIn vitro (cells)Efficacy outcome

    In bovine granulosa cell cultures, oxytocin inhibited estradiol production in both control and FSH-treated cultures.

    In plain wordsIn cultured cow ovary cells, oxytocin reduced estradiol production.

    Peptide
    Oxytocin
    Outcome
    DecreaseEstradiol production
    Study

    bovinen: not reported in source

    granulosa cells from bovine preovulatory follicles
    Comparator
    Culture without oxytocin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    P value
    < 0.01
    estradiol

    Source sentences

    Summary
    inhibited estradiol production (P < 0.01) in both control and FSH-treated cultures.
    1 context sentence
    Summary · context
    Granulosa cells were isolated from bovine preovulatory follicles and cultured for 3 days with or without OT in medium supplemented with either insulin (1 microgram/ml) + 1% fetal calf serum (FCS), which maintains basal estradiol secretion, or low doses of FSH (1 and 2 ng/ml) + 1% FCS, a culture cond…
  3. 03LabIn vitro (cells)Mechanism

    In bovine granulosa cells, oxytocin had only a small stimulatory effect on cytochrome P450 side-chain cleavage mRNA.

    In plain wordsIn cultured cow ovary cells, oxytocin slightly raised mRNA for a progesterone-making enzyme.

    Peptide
    Oxytocin
    Outcome
    IncreaseP450scc mRNA level
    Study

    bovinen: not reported in source

    granulosa cells from bovine preovulatory follicles
    Comparator
    Culture without oxytocin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT had only a small stimulatory effect on the levels of mRNA for P450scc and 3 beta-HSD
    1 context sentence
    Summary · context
    Granulosa cells were isolated from bovine preovulatory follicles and cultured for 3 days with or without OT in medium supplemented with either insulin (1 microgram/ml) + 1% fetal calf serum (FCS), which maintains basal estradiol secretion, or low doses of FSH (1 and 2 ng/ml) + 1% FCS, a culture cond…
  4. 04LabIn vitro (cells)Mechanism

    In bovine granulosa cells, oxytocin had only a small stimulatory effect on 3 beta-hydroxysteroid dehydrogenase mRNA.

    In plain wordsIn cultured cow ovary cells, oxytocin slightly raised mRNA for a second progesterone-making enzyme.

    Peptide
    Oxytocin
    Outcome
    Increase3 beta-HSD mRNA level
    Study

    bovinen: not reported in source

    granulosa cells from bovine preovulatory follicles
    Comparator
    Culture without oxytocin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT had only a small stimulatory effect on the levels of mRNA for P450scc and 3 beta-HSD
    1 context sentence
    Summary · context
    Granulosa cells were isolated from bovine preovulatory follicles and cultured for 3 days with or without OT in medium supplemented with either insulin (1 microgram/ml) + 1% fetal calf serum (FCS), which maintains basal estradiol secretion, or low doses of FSH (1 and 2 ng/ml) + 1% FCS, a culture cond…
  5. 05LabIn vitro (cells)Mechanism

    In bovine granulosa cells, oxytocin had no effect on cytochrome P450 aromatase mRNA.

    In plain wordsIn cultured cow ovary cells, oxytocin did not change mRNA for the estradiol-making enzyme.

    Peptide
    Oxytocin
    Outcome
    No significant changeP450arom mRNA level
    Study

    bovinen: not reported in source

    granulosa cells from bovine preovulatory follicles
    Comparator
    Culture without oxytocin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    no effect on mRNA for P450arom.
    1 context sentence
    Summary · context
    Granulosa cells were isolated from bovine preovulatory follicles and cultured for 3 days with or without OT in medium supplemented with either insulin (1 microgram/ml) + 1% fetal calf serum (FCS), which maintains basal estradiol secretion, or low doses of FSH (1 and 2 ng/ml) + 1% FCS, a culture cond…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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