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Study · Randomized controlled trial · n = 63 · 1996

4 results

Treatment with a gonadotrophin releasing hormone agonist before endometrial resection: a multicentre, randomised controlled trial.

Vercellini P, Perino A, Consonni R, Trespidi L, Parazzini F, Crosignani PG

British journal of obstetrics and gynaecology1 Jun 1996Cited by 22 (Europe PMC)

PMID8645650 (opens in a new tab)DOI10.1111/j.1471-0528.1996.tb09807.x (opens in a new tab)PepBankPUB-08645650
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In women with menorrhagia, operating time was 15.1 versus 16.9 min after goserelin versus immediate surgery, with the confidence interval crossing zero.

    In plain wordsOperating time did not clearly differ between goserelin pretreatment and immediate surgery.

    Peptide
    Goserelin
    Outcome
    No significant changeOperating time
    Study

    n = 63

    Comparator
    Immediate surgery without pretreatment
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · 8 weeksAs given in this study (human).

    Measurements

    Operating time
    15.1 min
    goserelin
    Operating time
    16.9 min
    controls
    Mean difference
    1.8 min
    reported contrast
    95% CI lower bound
    −2.9 min
    reported contrast
    95% CI upper bound
    6.4 min
    reported contrast

    Source sentences

    Summary
    Mean (SD) operating time was 15.1 (9.0) min in the goserelin group versus 16.9 (9.5) min in the controls; mean difference + 1.8 min, 95% CI, -2.9 to + 6.4.
    1 context sentence
    Summary · context
    A multicentre, prospective, randomised controlled study.ParticipantsSeventy-one premenopausal women with established menorrhagia.InterventionsEight weeks of goserelin depot treatment before endometrial resection of immediate surgery in the early proliferative phase of the cycle.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In women with menorrhagia, distension medium deficit was 422 versus 564 ml after goserelin versus immediate surgery, with the confidence interval crossing zero.

    In plain wordsDistension medium deficit did not clearly differ between goserelin pretreatment and immediate surgery.

    Peptide
    Goserelin
    Outcome
    No significant changeDistension medium deficit
    Study

    n = 63

    Comparator
    Immediate surgery without pretreatment
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · 8 weeksAs given in this study (human).

    Measurements

    Deficit
    422 ml
    goserelin
    Deficit
    564 ml
    controls
    Mean difference
    142 ml
    reported contrast
    95% CI lower bound
    −4 ml
    reported contrast
    95% CI upper bound
    288 ml
    reported contrast

    Source sentences

    Summary
    Mean (SD) distension medium deficit was, respectively, 422 (287) ml versus 564 (291 ml); mean difference + 142 ml, 95% CI -4 to + 288.
    1 context sentence
    Summary · context
    A multicentre, prospective, randomised controlled study.ParticipantsSeventy-one premenopausal women with established menorrhagia.InterventionsEight weeks of goserelin depot treatment before endometrial resection of immediate surgery in the early proliferative phase of the cycle.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In women with menorrhagia, surgical difficulty after goserelin versus immediate surgery was none in 6 versus 2, minimal in 20 versus 14, moderate in 7 versus 13, and severe in no cases versus 1.

    In plain wordsFewer goserelin-pretreated cases were rated moderate or severe difficulty than cases without pretreatment, based on surgeon ratings.

    Peptide
    Goserelin
    Outcome
    DecreaseIntraoperative difficulty
    Study

    n = 63

    Comparator
    Immediate surgery without pretreatment
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · 8 weeksAs given in this study (human).

    Measurements

    Intraoperative difficulty: none
    6 cases
    goserelin group
    Intraoperative difficulty: minimal
    20 cases
    goserelin group
    Intraoperative difficulty: moderate
    7 cases
    goserelin group
    Intraoperative difficulty: none
    2 cases
    group without pretreatment
    Intraoperative difficulty: minimal
    14 cases
    group without pretreatment
    Intraoperative difficulty: moderate
    13 cases
    group without pretreatment
    Intraoperative difficulty: severe
    1 cases
    group without pretreatment

    Source sentences

    Summary
    The surgeons classified the intraoperative difficulties as none in 6, minimal in 20, moderate in 7, and severe in no cases in the goserelin group; corresponding figures in the group without pretreatment were 2, 14, 13, and 1.
    1 context sentence
    Summary · context
    A multicentre, prospective, randomised controlled study.ParticipantsSeventy-one premenopausal women with established menorrhagia.InterventionsEight weeks of goserelin depot treatment before endometrial resection of immediate surgery in the early proliferative phase of the cycle.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In women with adenomyosis, fluid deficit was 299 versus 597 ml after goserelin versus immediate surgery.

    In plain wordsGoserelin pretreatment reduced fluid deficit versus immediate surgery in women with adenomyosis.

    Peptide
    Goserelin
    Outcome
    DecreaseFluid deficit in adenomyosis
    Study

    n = 29

    Comparator
    Immediate surgery without pretreatment
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · 8 weeksAs given in this study (human).

    Measurements

    Fluid deficit
    299 ml
    19 treated women
    Fluid deficit
    597 ml
    10 controls
    Mean difference
    298 ml
    reported contrast
    95% CI lower bound
    149 ml
    reported contrast
    95% CI upper bound
    447 ml
    reported contrast

    Source sentences

    Summary
    The goserelin effect was restricted to the 29 women with adenomyosis as the mean (SD) fluid deficit was considerably less in the 19 treated women than in the 10 controls (299 (206) ml versus 597 (135) ml; mean difference + 298 ml, 95% CI + 149 to + 447).
    1 context sentence
    Summary · context
    A multicentre, prospective, randomised controlled study.ParticipantsSeventy-one premenopausal women with established menorrhagia.InterventionsEight weeks of goserelin depot treatment before endometrial resection of immediate surgery in the early proliferative phase of the cycle.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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