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Study · In vitro (cells) · 1996

3 results

Platelet-activating factor enhances production of insulin-like growth factor binding proteins in a human adenocarcinoma cell line (HEC-1A)

Giannini S, Maggi M, Cresci B, Finetti G, Bonaccorsi L, Luconi M, Rotella CM, Forti G, Serio M, Baldi E

Gynecologic oncology1 Jun 1996Cited by 4 (Europe PMC)

PMID8641611 (opens in a new tab)DOI10.1006/gyno.1996.0152 (opens in a new tab)PepBankPUB-08641611
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HEC-1A cells, Des(1‑3)IGF-I produced a slight proliferative effect.

    In plain wordsIn cells, Des(1‑3)IGF-I slightly increased proliferation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseCell proliferation
    Study

    humann: not reported in source

    HEC-1A endometrial adenocarcinoma cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I and IGF-II (0.1-100 nM) are almost ineffective in inducing [3H]thymidine incorporation, whereas a slight proliferative effect is observed with Des(1-3)IGF-I which also increases PAF synthesis.
    1 context sentence
    Summary · context
    To investigate a possible cooperation between PAF and the insulin-like growth factor (IGF) system in this cell line, the effect of PAF on insulin-like growth factor binding protein (IGFBP) production as well as binding and biological activities of IGF-I, IGFv-II, and the analog Des(1-3)IGF-I have been evaluated.
  2. 02LabIn vitro (cells)Mechanism

    In HEC-1A cells, Des(1‑3)IGF-I increased PAF synthesis.

    In plain wordsIn cells, Des(1‑3)IGF-I increased PAF synthesis.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreasePAF synthesis
    Study

    humann: not reported in source

    HEC-1A endometrial adenocarcinoma cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I and IGF-II (0.1-100 nM) are almost ineffective in inducing [3H]thymidine incorporation, whereas a slight proliferative effect is observed with Des(1-3)IGF-I which also increases PAF synthesis.
    1 context sentence
    Summary · context
    To investigate a possible cooperation between PAF and the insulin-like growth factor (IGF) system in this cell line, the effect of PAF on insulin-like growth factor binding protein (IGFBP) production as well as binding and biological activities of IGF-I, IGFv-II, and the analog Des(1-3)IGF-I have been evaluated.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 03LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement

    In HEC-1A cells, Des(1‑3)IGF-I had lower binding affinity than IGF-I and IGF-II, with an affinity constant of 70 nM.

    In plain wordsIn cells, Des(1‑3)IGF-I bound the detected sites with lower affinity than IGF-I and IGF-II.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseBinding affinity
    Study

    humann: not reported in source

    HEC-1A endometrial adenocarcinoma cells
    Comparator
    IGF-I and IGF-II
    Outcome group
    Receptor activity and mechanism · Pharmacology

    Measurements

    Affinity constant
    70 nM
    Des(1-3)IGF-I binding to HEC-1A cells

    Source sentences

    Summary
    Analysis of self- and cross-displacement curves of [125I]IGF-I binding to HEC-1A cells indicates the presence of a single class of binding sites, with affinity constants of 1-4 nM for IGF-I and IGF-II and 70 nM for Des(1- 3)IGF-I, which binds to IGFBPs with lower affinity.
    1 context sentence
    Summary · context
    To investigate a possible cooperation between PAF and the insulin-like growth factor (IGF) system in this cell line, the effect of PAF on insulin-like growth factor binding protein (IGFBP) production as well as binding and biological activities of IGF-I, IGFv-II, and the analog Des(1-3)IGF-I have been evaluated.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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