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Study · Animal study (in vivo) · rat · 1996

7 results

Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.

Halmos G, Schally AV, Pinski J, Vadillo-Buenfil M, Groot K

Proceedings of the National Academy of Sciences of the United States of America1 Mar 1996Cited by 64 (Europe PMC)

PMID8637885 (opens in a new tab)PMCIDPMC39808 (opens in a new tab)DOI10.1073/pnas.93.6.2398 (opens in a new tab)PepBankPUB-08637885
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, receptor occupancy after cetrorelix was approximately 28%, 14%, and 10% at 1, 3, and 6 h.

    In plain wordsIn rats, cetrorelix occupied progressively fewer pituitary receptors after injection.

    Peptide
    Cetrorelix
    Outcome
    Not applicableLH-RH receptor occupancy
    Study

    ratn: not reported in source

    anterior pituitary after cetrorelix injection
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 microg per rat · injectionAs given in this study (rat).

    Measurements

    occupancy
    28%
    1 h
    occupancy
    14%
    3 h
    occupancy
    10%
    6 h

    Source sentences

    Summary
    Our results show that the percentages of occupied LH-RH receptors at 1, 3, and 6 h after administration of Cetrorelix were approximately 28%, 14%, and 10%, respectively, of total receptors.
    1 context sentence
    Summary · context
    In this study, the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single injection of Cetrorelix at a dose of 100 microg per rat.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, occupied LH-RH binding sites were undetectable at later intervals after cetrorelix.

    In plain wordsIn rats, occupied receptors were undetectable at later intervals after cetrorelix.

    Peptide
    Cetrorelix
    Outcome
    Direction not reportedLater receptor occupancy
    Study

    ratn: not reported in source

    anterior pituitary after cetrorelix injection
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 microg per rat · injectionAs given in this study (rat).

    Source sentences

    Summary
    At later time intervals, we could not detect occupied LH-RH binding sites.
    1 context sentence
    Summary · context
    In this study, the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single injection of Cetrorelix at a dose of 100 microg per rat.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, cetrorelix significantly down-regulated pituitary LH-RH receptors for at least 72 h (P < 0.01).

    In plain wordsIn rats, cetrorelix reduced pituitary receptor numbers for at least 72 h.

    Peptide
    Cetrorelix
    Outcome
    DecreaseLH-RH receptor down-regulation
    Study

    ratn: not reported in source

    anterior pituitary after cetrorelix injection
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 microg per rat · injectionAs given in this study (rat).

    Source sentences

    Summary
    Ligand competition assays, following in vitro desaturation, demonstrated that rat pituitary LH-RH receptors were significantly (P < 0.01) down-regulated for at least 72 h after administration of Cetrorelix.
    1 context sentence
    Summary · context
    In this study, the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single injection of Cetrorelix at a dose of 100 microg per rat.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, receptor concentrations were lowest 3-6 h after cetrorelix and began recovering within approximately 24 h.

    In plain wordsIn rats, receptor numbers began recovering within approximately 24 h after cetrorelix.

    Peptide
    Cetrorelix
    Outcome
    MixedReceptor recovery
    Study

    ratn: not reported in source

    anterior pituitary after cetrorelix injection
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 microg per rat · injectionAs given in this study (rat).

    Source sentences

    Summary
    The lowest receptor concentration was found 3-6 h after Cetrorelix treatment and a recovery in receptor number began within approximately 24 h.
    1 context sentence
    Summary · context
    In this study, the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single injection of Cetrorelix at a dose of 100 microg per rat.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, cetrorelix-induced receptor down-regulation accompanied serum LH suppression.

    In plain wordsIn rats, cetrorelix reduced serum LH alongside receptor numbers.

    Peptide
    Cetrorelix
    Outcome
    DecreaseSerum LH
    Study

    ratn: not reported in source

    anterior pituitary after cetrorelix injection
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 microg per rat · injectionAs given in this study (rat).

    Source sentences

    Summary
    The down-regulation of LH-RH binding sites induced by Cetrorelix was accompanied by serum LH and testosterone suppression.
    1 context sentence
    Summary · context
    In this study, the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single injection of Cetrorelix at a dose of 100 microg per rat.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, cetrorelix-induced receptor down-regulation accompanied testosterone suppression.

    In plain wordsIn rats, cetrorelix reduced testosterone alongside receptor numbers.

    Peptide
    Cetrorelix
    Outcome
    DecreaseSerum testosterone
    Study

    ratn: not reported in source

    anterior pituitary after cetrorelix injection
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 microg per rat · injectionAs given in this study (rat).

    Source sentences

    Summary
    The down-regulation of LH-RH binding sites induced by Cetrorelix was accompanied by serum LH and testosterone suppression.
    1 context sentence
    Summary · context
    In this study, the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single injection of Cetrorelix at a dose of 100 microg per rat.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In cetrorelix-treated rats, higher receptor concentrations coincided with elevated serum hormone levels at later intervals.

    In plain wordsIn rats given cetrorelix, higher receptor numbers coincided with higher hormone levels later.

    Peptide
    Cetrorelix
    Outcome
    IncreaseReceptor and hormone recovery association
    Study

    ratn: not reported in source

    anterior pituitary after cetrorelix injection
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    100 microg per rat · injectionAs given in this study (rat).

    Source sentences

    Summary
    Higher LH-RH receptor concentrations coincided with elevated serum hormone levels at later time intervals.
    1 context sentence
    Summary · context
    In this study, the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single injection of Cetrorelix at a dose of 100 microg per rat.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

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