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Study · Ex vivo tissue · mouse · 1995

6 results

Thymosin alpha-1 and FA-1 monoclonal antibody affect murine preimplantation embryo development by modulating protein phosphorylation.

Ahmad K, Naz RK

Journal of reproductive immunology1 Oct 1995Cited by 4 (Europe PMC)

PMID8636928 (opens in a new tab)DOI10.1016/0165-0378(95)00943-f (opens in a new tab)PepBankPUB-08636928
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In cultured mouse 2-cell embryos, thymosin alpha‑1 significantly increased blastulation rates.

    In plain wordsIn lab-cultured mouse embryos, thymosin alpha‑1 raised the share of embryos reaching the blastula stage.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseBlastulation rate
    Study

    mousen: not reported in source

    In vitro cultured murine preimplantation embryos
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    0.1, 0.5 and 5 ng/100 microlitersAs given in this study (mouse).

    Source sentences

    Summary
    T alpha 1 treatment (0.1, 0.5 and 5 ng/100 microliters) significantly increased blastulation rates (P < 0.01), blastocyst hatching rate (P < 0.0001), blastocyst diameter (P < 0.001) and number of cells per blastocyst (P < 0.0001) of the in vitro cultured 2-cell stage embryos.
    1 context sentence
    Summary · context
    The effects of thymosin alpha 1 (T alpha 1) and FA-1 monoclonal antibody (anti-FA-1 mAb) on murine preimplantation embryonic development were investigated by performing 2-cell embryo bioassay and by studying ova/embryos protein phosphorylation pattern (by 32P metabolic labeling and by in vitro kinas…
  2. 02LabEx vivo tissueEfficacy outcome

    In cultured mouse 2-cell embryos, thymosin alpha‑1 significantly increased the blastocyst hatching rate.

    In plain wordsIn lab-cultured mouse embryos, thymosin alpha‑1 raised the share of blastocysts that hatched.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseBlastocyst hatching rate
    Study

    mousen: not reported in source

    In vitro cultured murine preimplantation embryos
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    0.1, 0.5 and 5 ng/100 microlitersAs given in this study (mouse).

    Source sentences

    Summary
    T alpha 1 treatment (0.1, 0.5 and 5 ng/100 microliters) significantly increased blastulation rates (P < 0.01), blastocyst hatching rate (P < 0.0001), blastocyst diameter (P < 0.001) and number of cells per blastocyst (P < 0.0001) of the in vitro cultured 2-cell stage embryos.
    1 context sentence
    Summary · context
    The effects of thymosin alpha 1 (T alpha 1) and FA-1 monoclonal antibody (anti-FA-1 mAb) on murine preimplantation embryonic development were investigated by performing 2-cell embryo bioassay and by studying ova/embryos protein phosphorylation pattern (by 32P metabolic labeling and by in vitro kinas…
  3. 03LabEx vivo tissueEfficacy outcome

    In cultured mouse 2-cell embryos, thymosin alpha‑1 significantly increased blastocyst diameter.

    In plain wordsIn lab-cultured mouse embryos, thymosin alpha‑1 made blastocysts larger.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseBlastocyst diameter
    Study

    mousen: not reported in source

    In vitro cultured murine preimplantation embryos
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    0.1, 0.5 and 5 ng/100 microlitersAs given in this study (mouse).

    Source sentences

    Summary
    T alpha 1 treatment (0.1, 0.5 and 5 ng/100 microliters) significantly increased blastulation rates (P < 0.01), blastocyst hatching rate (P < 0.0001), blastocyst diameter (P < 0.001) and number of cells per blastocyst (P < 0.0001) of the in vitro cultured 2-cell stage embryos.
    1 context sentence
    Summary · context
    The effects of thymosin alpha 1 (T alpha 1) and FA-1 monoclonal antibody (anti-FA-1 mAb) on murine preimplantation embryonic development were investigated by performing 2-cell embryo bioassay and by studying ova/embryos protein phosphorylation pattern (by 32P metabolic labeling and by in vitro kinas…
  4. 04LabEx vivo tissueEfficacy outcome

    In cultured mouse 2-cell embryos, thymosin alpha‑1 significantly increased the number of cells per blastocyst.

    In plain wordsIn lab-cultured mouse embryos, thymosin alpha‑1 increased the number of cells in each blastocyst.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseNumber of cells per blastocyst
    Study

    mousen: not reported in source

    In vitro cultured murine preimplantation embryos
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    0.1, 0.5 and 5 ng/100 microlitersAs given in this study (mouse).

    Source sentences

    Summary
    T alpha 1 treatment (0.1, 0.5 and 5 ng/100 microliters) significantly increased blastulation rates (P < 0.01), blastocyst hatching rate (P < 0.0001), blastocyst diameter (P < 0.001) and number of cells per blastocyst (P < 0.0001) of the in vitro cultured 2-cell stage embryos.
    1 context sentence
    Summary · context
    The effects of thymosin alpha 1 (T alpha 1) and FA-1 monoclonal antibody (anti-FA-1 mAb) on murine preimplantation embryonic development were investigated by performing 2-cell embryo bioassay and by studying ova/embryos protein phosphorylation pattern (by 32P metabolic labeling and by in vitro kinas…
  5. 05LabEx vivo tissueMechanism

    In mouse 2-cell, morula and blastocyst stage embryos, thymosin alpha‑1 produced a general increase in 32P labeling of proteins.

    In plain wordsIn lab-cultured mouse embryos, thymosin alpha‑1 increased protein phosphorylation in several embryo stages.

    Peptide
    Thymosin alpha-1
    Outcome
    Increase32P protein labeling (protein phosphorylation)
    Study

    mousen: not reported in source

    In vitro cultured murine preimplantation embryos
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    0.1-0.5 ng/100 microlitersAs given in this study (mouse).

    Source sentences

    Summary
    T alpha 1 treatment (0.1-0.5 ng/100 microliters) resulted in a general increase in 32P labeling in all proteins of 2-cell, morula and blastocyst stage embryos.
    1 context sentence
    Summary · context
    The effects of thymosin alpha 1 (T alpha 1) and FA-1 monoclonal antibody (anti-FA-1 mAb) on murine preimplantation embryonic development were investigated by performing 2-cell embryo bioassay and by studying ova/embryos protein phosphorylation pattern (by 32P metabolic labeling and by in vitro kinas…
  6. 06LabEx vivo tissueMechanism

    In mouse 2-cell embryo extracts, thymosin alpha‑1 specifically enhanced autophosphorylation of a 55 kDa protein.

    In plain wordsIn lab tests with mouse embryo extracts, thymosin alpha‑1 increased phosphorylation of one 55 kDa protein.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAutophosphorylation of 55 kDa protein in 2-cell embryos
    Study

    mousen: not reported in source

    In vitro cultured murine preimplantation embryos
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of these phosphoproteins, T alpha 1 treatment specifically enhanced whereas anti-FA-1 mAb inhibited autophosphorylation of a 55 kDa protein of 2-cell embryos
    1 context sentence
    Summary · context
    The effects of thymosin alpha 1 (T alpha 1) and FA-1 monoclonal antibody (anti-FA-1 mAb) on murine preimplantation embryonic development were investigated by performing 2-cell embryo bioassay and by studying ova/embryos protein phosphorylation pattern (by 32P metabolic labeling and by in vitro kinas…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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