Skip to content

Study · Observational study · n = 18 · 1996

3 results

Different growth hormone (GH) response to GH-releasing peptide and GH-releasing hormone in hyperthyroidism.

Ramos-Dias JC, Pimentel-Filho F, Reis AF, Lengyel AM

The Journal of clinical endocrinology and metabolism1 Apr 1996Cited by 15 (Europe PMC)

PMID8636330 (opens in a new tab)DOI10.1210/jcem.81.4.8636330 (opens in a new tab)PepBankPUB-08636330
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanObservational studyEfficacy outcome

    In patients with hyperthyroidism and control subjects, GH peak after isolated GHRP‑6 injection was similar in both groups.

    In plain wordsIn people with an overactive thyroid and in healthy people, GHRP‑6 alone raised growth hormone to a similar level.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH peak after GHRP-6 alone
    Study

    n = 18

    Comparator
    Healthy control subjects
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg · intravenousAs given in this study (human).

    Measurements

    GH peak
    31.9 micrograms per L
    hyperthyroid patients
    GH peak
    23.2 micrograms per L
    control subjects

    Source sentences

    Summary
    However, a similar GH response was seen in both groups after isolated GHRP-6 injection (31.9 +/- 5.7 vs. 23.2 +/- 3.9).
    2 context sentences
    Summary · context
    The aim of this study was to evaluate the effects of GHRP-6 on GH secretion in patients with hyperthyroidism (n = 9) and in control subjects (n = 9).
    Summary · context
    Each subject received GHRP-6 (1 microg/kg, iv), GHRH (100 microg, iv), and GHRP-6 plus GHRH on 3 separate days.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 02HumanNot a test of GHRP-6 aloneObservational studyEfficacy outcome

    In patients with hyperthyroidism, GH peak after combined GHRP‑6 and GHRH was lower than in control subjects.

    In plain wordsIn people with an overactive thyroid, GHRP‑6 given with GHRH raised growth hormone less than in healthy people.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH peak after GHRP-6 plus GHRH
    Study

    n = 18

    Comparator
    Healthy control subjects
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH peak
    22.5 micrograms per L
    hyperthyroid patients
    GH peak
    83.7 micrograms per L
    control subjects

    Source sentences

    Summary
    GH peak values (mean +/- SE; micrograms per L) were significantly lower in hyperthyroid patients compared to those in control subjects after GHRH alone (9.0 +/- 1.3 vs. 27.0 +/- 5.2) and GHRP-6 plus GHRH (22.5 +/- 3.5 vs. 83.7 +/- 15.2)
    2 context sentences
    Summary · context
    The aim of this study was to evaluate the effects of GHRP-6 on GH secretion in patients with hyperthyroidism (n = 9) and in control subjects (n = 9).
    Summary · context
    Each subject received GHRP-6 (1 microg/kg, iv), GHRH (100 microg, iv), and GHRP-6 plus GHRH on 3 separate days.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 03HumanNot a test of GHRP-6 aloneObservational studyEfficacy outcome

    In patients with hyperthyroidism, the normal synergistic effect of GHRP‑6 together with GHRH on GH release was absent.

    In plain wordsIn people with an overactive thyroid, the usual extra growth hormone boost from giving GHRP‑6 with GHRH did not occur.

    Peptide
    GHRP-6
    Outcome
    No significant changeSynergy of GHRP-6 with GHRH
    Study

    n = 18

    Comparator
    Healthy control subjects
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    a lack of the normal synergistic effect of the association of both peptides was observed in thyrotoxicosis.
    2 context sentences
    Summary · context
    The aim of this study was to evaluate the effects of GHRP-6 on GH secretion in patients with hyperthyroidism (n = 9) and in control subjects (n = 9).
    Summary · context
    Each subject received GHRP-6 (1 microg/kg, iv), GHRH (100 microg, iv), and GHRP-6 plus GHRH on 3 separate days.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.