In IGFBP-5-overexpressing myoblasts, des (1-3) IGF-I overcame inhibited differentiation with the highest potency among exogenous IGFs.
In plain wordsIn cells, des (1-3) IGF-I reversed inhibited muscle differentiation more potently than other tested IGFs.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- IncreaseMyogenic differentiation
- Study
n: not reported in source
IGFBP-5 sense-transfected C2 myoblasts- Comparator
- Other exogenous IGFs
- Outcome group
- Muscle injury and repair · Musculoskeletal
- Studied dose
- Dose not stated
Source sentences
The inhibition of myogenic differentiation by high level expression of IGFBP-5 could be overcome by exogenous IGFs, with des (1-3) IGF-I, an analogue with decreased affinity for IGFBP-5 but normal affinity for the IGF-I receptor, showing the highest potency.
1 context sentence(design, population, supporting numbers)
We stably transfected C2 cells with IGFBP-5 cDNAs under control of a constitutively active promoter.