In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice.

Mizutani M, El-Fotoh M, Mori M, Ono K, Doi K, Awaya A, Matsumoto Y, Matsumoto Y, Onodera T

Archives of virology1 Jan 1996Cited by 17 (Europe PMC)

PMID8629952DOI10.1007/bf01718589PepBankPUB-08629952

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In mice infected with 10 PFU of EMC-D virus, FTS pretreatment prevented diabetes, whereas 40% of untreated mice developed diabetes.
In plain wordsIn mice infected with 10 PFU of virus, FTS pretreatment prevented diabetes compared with untreated mice.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseDiabetes after low viral challenge
Study
mousen: not reported in source
EMC-D virus-infected BALB/cAJcl mice
Comparator
FTS non-treated mice
Outcome group
Glycemic control · Metabolic and weight
Studied dose
50 micrograms/administration · day 2 and 1 before infectionAs given in this study (mouse).
Measurements
Diabetes incidence
40%
untreated mice on PID 14
Source sentences
Summary
In the mice inoculated with 10 PFU of virus, 40% developed diabetes on post-infection day (PID) 14, whereas those treated with FTS (50 micrograms/administration) on day 2 and 1 before infection did not develop diabetes.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of serum thymic factor (FTS) on the D-variant of encephalomyocarditis (EMC-D) virus-induced diabetes and myocarditis in BALB/cAJcl mice was investigated.
Summary · context
Mice pretreated with 50 or 10 micrograms of FTS were infected with 10 or 10(3) PFU of EMC-D virus.
Report a problemFND-0862995201
02AnimalAnimal study (in vivo)Efficacy outcome
In EMC-D virus-infected mice, diabetes developed despite pretreatment with 10 micrograms of FTS.
In plain wordsIn virus-infected mice, diabetes developed despite FTS pretreatment.
Peptide
Thymulin (serum thymic factor)
Outcome
Direction not reportedDiabetes with lower FTS dose
Study
mousen: not reported in source
EMC-D virus-infected BALB/cAJcl mice
Outcome group
Glycemic control · Metabolic and weight
Studied dose
10 microgramsAs given in this study (mouse).
Source sentences
Summary
FTS (10 micrograms)-pretreated mice developed diabetes.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of serum thymic factor (FTS) on the D-variant of encephalomyocarditis (EMC-D) virus-induced diabetes and myocarditis in BALB/cAJcl mice was investigated.
Summary · context
Mice pretreated with 50 or 10 micrograms of FTS were infected with 10 or 10(3) PFU of EMC-D virus.
Report a problemFND-0862995202
03AnimalAnimal study (in vivo)Efficacy outcome
In EMC-D virus-infected mice, FTS pretreatment was associated with mild islet degeneration rather than the severe necrosis in untreated diabetic mice.
In plain wordsIn virus-infected mice, FTS pretreatment was linked to milder islet damage than in untreated diabetic mice.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseIslet degeneration
Study
mousen: not reported in source
EMC-D virus-infected BALB/cAJcl mice
Comparator
FTS non-treated mice
Outcome group
Glycemic control · Metabolic and weight
Studied dose
50 microgramsAs given in this study (mouse).
Source sentences
Summary
Mice pretreated with 50 micrograms of FTS, however, manifested mild islet degeneration without any myocardial inflammation.
3 context sentences(design, population, supporting numbers)
Summary · context
In histological observation, FTS non-treated mice which developed diabetes showed severe necrosis and inflammation of mononuclear cells in the islets of Langerhans and myocardia on 19 PID.
Summary · context
The effect of serum thymic factor (FTS) on the D-variant of encephalomyocarditis (EMC-D) virus-induced diabetes and myocarditis in BALB/cAJcl mice was investigated.
Summary · context
Mice pretreated with 50 or 10 micrograms of FTS were infected with 10 or 10(3) PFU of EMC-D virus.
Report a problemFND-0862995203
04AnimalAnimal study (in vivo)Efficacy outcome
In EMC-D virus-infected mice, FTS pretreatment prevented myocardial inflammation observed in untreated diabetic mice.
In plain wordsIn virus-infected mice, FTS pretreatment prevented heart inflammation observed in untreated diabetic mice.
Peptide
Thymulin (serum thymic factor)
Outcome
DecreaseMyocardial inflammation
Study
mousen: not reported in source
EMC-D virus-infected BALB/cAJcl mice
Comparator
FTS non-treated mice
Outcome group
Inflammation markers · Cardiovascular
Studied dose
50 microgramsAs given in this study (mouse).
Source sentences
Summary
Mice pretreated with 50 micrograms of FTS, however, manifested mild islet degeneration without any myocardial inflammation.
3 context sentences(design, population, supporting numbers)
Summary · context
In histological observation, FTS non-treated mice which developed diabetes showed severe necrosis and inflammation of mononuclear cells in the islets of Langerhans and myocardia on 19 PID.
Summary · context
The effect of serum thymic factor (FTS) on the D-variant of encephalomyocarditis (EMC-D) virus-induced diabetes and myocarditis in BALB/cAJcl mice was investigated.
Summary · context
Mice pretreated with 50 or 10 micrograms of FTS were infected with 10 or 10(3) PFU of EMC-D virus.
Report a problemFND-0862995204
05AnimalAnimal study (in vivo)Efficacy outcome
In EMC-D virus-infected mice, FTS pretreatment reversed insulin granule loss observed in untreated mice.
In plain wordsIn virus-infected mice, FTS pretreatment preserved insulin granules compared with untreated mice.
Peptide
Thymulin (serum thymic factor)
Outcome
IncreaseInsulin granule preservation
Study
mousen: not reported in source
EMC-D virus-infected BALB/cAJcl mice
Comparator
FTS non-treated mice
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
This loss was markedly reversed and insulin granules remained largely intact in FTS-pretreated mice.
3 context sentences(design, population, supporting numbers)
Summary · context
Furthermore, in FTS non-treated mice, immunohistological staining showed a loss of insulin granules.
Summary · context
The effect of serum thymic factor (FTS) on the D-variant of encephalomyocarditis (EMC-D) virus-induced diabetes and myocarditis in BALB/cAJcl mice was investigated.
Summary · context
Mice pretreated with 50 or 10 micrograms of FTS were infected with 10 or 10(3) PFU of EMC-D virus.
Report a problemFND-0862995205
06AnimalAnimal study (in vivo)Efficacy outcome
In EMC-D virus-infected mice, pancreatic viral titers after FTS pretreatment approximated untreated values on PID 4, 7 and 19.
In plain wordsIn virus-infected mice, pancreatic virus levels were similar after FTS pretreatment and no treatment.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changePancreatic viral titers
Study
mousen: not reported in source
EMC-D virus-infected BALB/cAJcl mice
Comparator
FTS non-treated mice
Outcome group
Antiviral activity · Infection
Studied dose
Dose not stated
Source sentences
Summary
Viral titers in pancreas of FTS-pretreated mice approximated well to those of non-treated mice on PID 4, 7 and 19.
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of serum thymic factor (FTS) on the D-variant of encephalomyocarditis (EMC-D) virus-induced diabetes and myocarditis in BALB/cAJcl mice was investigated.
Summary · context
Mice pretreated with 50 or 10 micrograms of FTS were infected with 10 or 10(3) PFU of EMC-D virus.
Report a problemFND-0862995206
07AnimalAnimal study (in vivo)Efficacy outcome
In mice infected with 10(3) PFU of EMC-D virus, FTS pretreatment did not change the course of diabetes.
In plain wordsIn mice given the higher virus challenge, FTS pretreatment did not change the course of diabetes.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeDiabetes after high viral challenge
Study
mousen: not reported in source
EMC-D virus-infected BALB/cAJcl mice
Comparator
FTS non-treated mice
Outcome group
Glycemic control · Metabolic and weight
Studied dose
50 microgramsAs given in this study (mouse).
Source sentences
Summary
In mice inoculated with higher titer of EMC-D virus (10(3) PFU), however, 50 micrograms of FTS pretreatment did not change the course of these acute pathological developments (diabetes and myocarditis observed from PID 4).
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of serum thymic factor (FTS) on the D-variant of encephalomyocarditis (EMC-D) virus-induced diabetes and myocarditis in BALB/cAJcl mice was investigated.
Summary · context
Mice pretreated with 50 or 10 micrograms of FTS were infected with 10 or 10(3) PFU of EMC-D virus.
Report a problemFND-0862995207
08AnimalAnimal study (in vivo)Efficacy outcome
In mice infected with 10(3) PFU of EMC-D virus, FTS pretreatment did not change the course of myocarditis.
In plain wordsIn mice given the higher virus challenge, FTS pretreatment did not change the course of heart inflammation.
Peptide
Thymulin (serum thymic factor)
Outcome
No significant changeMyocarditis after high viral challenge
Study
mousen: not reported in source
EMC-D virus-infected BALB/cAJcl mice
Comparator
FTS non-treated mice
Outcome group
Heart function · Cardiovascular
Studied dose
50 microgramsAs given in this study (mouse).
Source sentences
Summary
In mice inoculated with higher titer of EMC-D virus (10(3) PFU), however, 50 micrograms of FTS pretreatment did not change the course of these acute pathological developments (diabetes and myocarditis observed from PID 4).
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of serum thymic factor (FTS) on the D-variant of encephalomyocarditis (EMC-D) virus-induced diabetes and myocarditis in BALB/cAJcl mice was investigated.
Summary · context
Mice pretreated with 50 or 10 micrograms of FTS were infected with 10 or 10(3) PFU of EMC-D virus.
Report a problemFND-0862995208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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