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Study · Randomized controlled trial · n = 50 · 1996

9 results

High-dose growth hormone treatment of short children born small for gestational age.

de Zegher F, Maes M, Gargosky SE, Heinrichs C, Du Caju MV, Thiry G, De Schepper J, Craen M, Breysem L, Löfström A, Jönsson P, Bourguignon JP, Malvaux P, Rosenfeld RG

The Journal of clinical endocrinology and metabolism1 May 1996Cited by 59 (Europe PMC)

PMID8626853 (opens in a new tab)DOI10.1210/jcem.81.5.8626853 (opens in a new tab)PepBankPUB-08626853
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In short children born small for gestational age, catch-up growth occurred in all GH-treated children and no untreated children.

    In plain wordsIn short children born small for gestational age, all GH-treated children and no untreated children showed catch-up growth.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseCatch-up growth
    Study

    n = 50

    Comparator
    Untreated children
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Source sentences

    Summary
    Catch-up growth was observed in none of the untreated and all of the treated children.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In short children born small for gestational age, growth responses differed only slightly between the two GH doses.

    In plain wordsIn short children born small for gestational age, growth responses differed only slightly between the two GH doses.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableGrowth response between doses
    Study

    n: not reported in source

    Comparator
    The other GH dose
    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Source sentences

    Summary
    The differences between the growth responses evoked by the two GH doses were minor.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.
  3. 03HumanNon-randomized trialEfficacy outcome

    In short children born small for gestational age, GH treatment nearly doubled growth velocity.

    In plain wordsIn short children born small for gestational age, GH treatment nearly doubled growth velocity.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseGrowth velocity
    Study

    n: not reported in source

    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Source sentences

    Summary
    The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.
  4. 04HumanNon-randomized trialEfficacy outcome

    In short children born small for gestational age, GH treatment nearly doubled weight gain.

    In plain wordsIn short children born small for gestational age, GH treatment nearly doubled weight gain.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseWeight gain
    Study

    n: not reported in source

    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Source sentences

    Summary
    The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.
  5. 05HumanNon-randomized trialEfficacy outcome

    In short children born small for gestational age, GH treatment produced a mean height increment greater than 2 SDS.

    In plain wordsIn short children born small for gestational age, mean height increased by more than 2 SDS with GH.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseHeight increment
    Study

    n: not reported in source

    Outcome group
    Linear growth · Endocrine and hormones
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Measurements

    Mean height increment
    > 2 SDS
    GH treatment

    Source sentences

    Summary
    The response to GH treatment included a near doubling of growth velocity and of weight gain and a mean height increment of more than 2 SDS.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.
  6. 06HumanNon-randomized trialEfficacy outcome

    In short children born small for gestational age, GH treatment was associated with accelerated bone maturation.

    In plain wordsIn short children born small for gestational age, GH treatment was linked to faster bone maturation.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseBone maturation
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Source sentences

    Summary
    GH treatment was associated with a distinct acceleration of bone maturation.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.
  7. 07HumanNon-randomized trialEfficacy outcome

    In short children born small for gestational age, GH-induced catch-up growth accompanied elevated serum insulin, IGF-I, IGFBP-3, and osteocalcin.

    In plain wordsIn short children born small for gestational age, insulin, IGF-I, IGFBP-3, and osteocalcin were elevated during GH-induced catch-up growth.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseElevated insulin, IGF-I, IGFBP-3, and osteocalcin
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Source sentences

    Summary
    The prepubertal GH-induced catch-up growth was associated with elevated serum concentrations of insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and osteocalcin, whereas insulin-like growth factor-II levels remained unaltered.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.
  8. 08HumanNon-randomized trialEfficacy outcome

    In short children born small for gestational age, serum IGF-II remained unaltered during GH-induced catch-up growth.

    In plain wordsIn short children born small for gestational age, serum IGF-II did not change during GH-induced catch-up growth.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeSerum IGF-II
    Study

    n: not reported in source

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Source sentences

    Summary
    The prepubertal GH-induced catch-up growth was associated with elevated serum concentrations of insulin, insulin-like growth factor-I, insulin-like growth factor binding protein-3, and osteocalcin, whereas insulin-like growth factor-II levels remained unaltered.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.
  9. 09HumanNon-randomized trialSafety outcome

    In short children born small for gestational age, GH treatment was well tolerated.

    In plain wordsIn short children born small for gestational age, GH treatment was well tolerated.

    Peptide
    HGH (somatotropin)
    Outcome
    Not applicableTolerability
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    0.2 or 0.3 IU/kg daily · sc · 2 yrAs given in this study (human).

    Source sentences

    Summary
    GH treatment was well tolerated.
    1 context sentence
    Summary · context
    The effect of GH administration was evaluated over 2 yr in 50 short, prepubertal, non-GH deficient children born small for gestational age, who had been randomly allocated to a group receiving no treatment or daily sc GH treatment at a dose of 0.2 or 0.3 IU/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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