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Study · Animal study (in vivo) · rat · 1995

2 results

Intracerebroventricular growth-hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats.

Locke W, Kirgis HD, Bowers CY, Abdoh AA

Life sciences1 Mar 1995Cited by 72 (Europe PMC)

PMID8614257 (opens in a new tab)DOI10.1016/0024-3205(95)00087-9 (opens in a new tab)PepBankPUB-08614257
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sated rats, GHRP‑6 dose showed a nearly linear positive relationship with eating incidence.

    In plain wordsIn sated rats, higher GHRP‑6 doses increased the likelihood of eating.

    Peptide
    GHRP-6
    Outcome
    IncreaseIncidence of eating
    Study

    ratn: not reported in source

    Sated adult male Sprague-Dawley rats
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0 to 1000 pmol · intracerebroventricular · 60 minutesAs given in this study (rat).

    Source sentences

    Summary
    A nearly linear, statistically significant (p < 0.01) dose-response relationship between the dose of GHRP-6 and the incidence of eating was noted.
    1 context sentence
    Summary · context
    GHRP-6 dissolved in 5 microL of saline was injected into the lateral ventricles of sated, adult, male, Sprague-Dawley rats in doses from 0 pmol (saline only) to 1000 pmol. For 1 hour after injection, the occurrence of eating was noted, and specimens of arterial blood were collected at 0, 15, 30, and 60 minutes.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In sated rats, plasma GH changes from baseline after GHRP‑6 were not dose-related at the measured time points.

    In plain wordsIn sated rats, growth hormone changes after GHRP‑6 did not vary significantly with dose at the measured times.

    Peptide
    GHRP-6
    Outcome
    No significant changeDose relationship of plasma GH change
    Study

    ratn: not reported in source

    Sated adult male Sprague-Dawley rats
    Comparator
    Different GHRP-6 doses
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0 to 1000 pmol · intracerebroventricular · 60 minutesAs given in this study (rat).

    Source sentences

    Summary
    The mean change from baseline of plasma GH during the 60 minutes after injection was not dose-related (p > 0.2, p > 0.1, and p > 0.1 at 15, 30, and 60 minutes, respectively).
    1 context sentence
    Summary · context
    GHRP-6 dissolved in 5 microL of saline was injected into the lateral ventricles of sated, adult, male, Sprague-Dawley rats in doses from 0 pmol (saline only) to 1000 pmol. For 1 hour after injection, the occurrence of eating was noted, and specimens of arterial blood were collected at 0, 15, 30, and 60 minutes.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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