Acadesine reduces the frequency of coronary artery reocclusion following rt-PA induced thrombolysis in the dog.

Young MA, Henry C, Wong S, Bullough D, Mullane K

Thrombosis and haemostasis1 Nov 1995Cited by 6 (Europe PMC)

PMID8607121DOI10.1055/s-0038-1649938PepBankPUB-08607121

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In dogs receiving t-PA and low-dose acadesine, all treated vessels reoccluded.
In plain wordsIn dogs receiving t-PA and low-dose acadesine, all treated vessels blocked again.
Peptide
AICAR (acadesine)
Outcome
Not applicableReocclusion incidence, lowest dose
Study
dogn = 3
Coronary thrombolysis and reocclusion after t-PA
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
0.5 mg/kg/min · intravenousAs given in this study (dog).
Measurements
Reocclusion incidence
100%
0.5 mg/kg/min acadesine
Animals with reocclusion
3 animals
of 3 animals
Source sentences
Summary
With the lowest dose of acadesine (0.5 mg/kg/min) vessels reoccluded in 3 of 3 animals (100%) at 18 +/- 7 min.
1 context sentence(design, population, supporting numbers)
Summary · context
In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5, 1.0, 2.0 mg/kg/min, i.v.) on time reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 micrograms/kg/min, i.v.).
Report a problemFND-0860712102
02AnimalAnimal study (in vivo)Efficacy outcome
In dogs receiving t-PA and low-dose acadesine, vessels reoccluded at 18 +/- 7 min.
In plain wordsIn dogs receiving t-PA and low-dose acadesine, vessels blocked again at 18 +/- 7 minutes.
Peptide
AICAR (acadesine)
Outcome
Not applicableTime to reocclusion, lowest dose
Study
dogn = 3
Coronary thrombolysis and reocclusion after t-PA
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
0.5 mg/kg/min · intravenousAs given in this study (dog).
Measurements
Time to reocclusion
18 min
0.5 mg/kg/min acadesine
Reported uncertainty
7 min
type not stated
Source sentences
Summary
With the lowest dose of acadesine (0.5 mg/kg/min) vessels reoccluded in 3 of 3 animals (100%) at 18 +/- 7 min.
1 context sentence(design, population, supporting numbers)
Summary · context
In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5, 1.0, 2.0 mg/kg/min, i.v.) on time reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 micrograms/kg/min, i.v.).
Report a problemFND-0860712103
03AnimalAnimal study (in vivo)Efficacy outcome
In dogs receiving t-PA, acadesine did not affect time to coronary reperfusion versus saline.
In plain wordsIn dogs receiving t-PA, acadesine did not change the time to restored coronary blood flow compared with saline.
Peptide
AICAR (acadesine)
Outcome
No significant changeTime to reperfusion
Study
dogn: not reported in source
Coronary thrombolysis and reocclusion after t-PA
Comparator
Saline with t-PA
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
0.5, 1.0, 2.0 mg/kg/min · intravenousAs given in this study (dog).
Source sentences
Summary
Acadesine had no effect on time to reperfusion, but significantly (p < 0.05) reduced the incidence of reocclusion and prolonged the time to reocclusion at the highest dose tested.
1 context sentence(design, population, supporting numbers)
Summary · context
In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5, 1.0, 2.0 mg/kg/min, i.v.) on time reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 micrograms/kg/min, i.v.).
Report a problemFND-0860712101
04AnimalAnimal study (in vivo)Efficacy outcome
In dogs receiving t-PA, intermediate-dose acadesine numerically reduced reocclusion versus saline, without statistical significance.
In plain wordsIn dogs receiving t-PA, intermediate-dose acadesine showed fewer repeat blockages than saline, but the difference was not significant.
Peptide
AICAR (acadesine)
Outcome
No significant changeReocclusion incidence, intermediate dose
Study
dogn: not reported in source
Coronary thrombolysis and reocclusion after t-PA
Comparator
Saline with t-PA
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
1.0 mg/kg/min · intravenousAs given in this study (dog).
Measurements
Reocclusion incidence
33%
1.0 mg/kg/min acadesine
Animals with reocclusion
2 animals
of 6 animals
Source sentences
Summary
In animals treated with 1.0 mg/kg/min acadesine, the incidence of reocclusion was reduced, but not significantly (p < 0.1) to 2 of 6 (33%), and time to reocclusion was prolonged to 59 +/- 11 min (p < 0.1).
1 context sentence(design, population, supporting numbers)
Summary · context
In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5, 1.0, 2.0 mg/kg/min, i.v.) on time reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 micrograms/kg/min, i.v.).
Report a problemFND-0860712104
05AnimalAnimal study (in vivo)Efficacy outcome
In dogs receiving t-PA, intermediate-dose acadesine numerically prolonged time to reocclusion versus saline, without statistical significance.
In plain wordsIn dogs receiving t-PA, intermediate-dose acadesine delayed repeat blockage compared with saline, but the difference was not significant.
Peptide
AICAR (acadesine)
Outcome
No significant changeTime to reocclusion, intermediate dose
Study
dogn: not reported in source
Coronary thrombolysis and reocclusion after t-PA
Comparator
Saline with t-PA
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
1.0 mg/kg/min · intravenousAs given in this study (dog).
Measurements
Time to reocclusion
59 min
1.0 mg/kg/min acadesine
Reported uncertainty
11 min
type not stated
Source sentences
Summary
In animals treated with 1.0 mg/kg/min acadesine, the incidence of reocclusion was reduced, but not significantly (p < 0.1) to 2 of 6 (33%), and time to reocclusion was prolonged to 59 +/- 11 min (p < 0.1).
1 context sentence(design, population, supporting numbers)
Summary · context
In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5, 1.0, 2.0 mg/kg/min, i.v.) on time reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 micrograms/kg/min, i.v.).
Report a problemFND-0860712105
06AnimalAnimal study (in vivo)Efficacy outcome
In dogs receiving t-PA, high-dose acadesine reduced reocclusion incidence versus saline.
In plain wordsIn dogs receiving t-PA, high-dose acadesine reduced repeat coronary blockages compared with saline.
Peptide
AICAR (acadesine)
Outcome
DecreaseReocclusion incidence, highest dose
Study
dogn: not reported in source
Coronary thrombolysis and reocclusion after t-PA
Comparator
Saline with t-PA
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
2.0 mg/kg/min · intravenousAs given in this study (dog).
Measurements
Reocclusion incidence
25%
2.0 mg/kg/min acadesine
Animals with reocclusion
2 animals
of 8 animals
Source sentences
Summary
At the highest dose (2.0 mg/kg/min) of acadesine, only 2 of 8 (25%) animals reoccluded (p < 0.05), and time to occlusion was prolonged to 80 +/- 13 min (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5, 1.0, 2.0 mg/kg/min, i.v.) on time reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 micrograms/kg/min, i.v.).
Report a problemFND-0860712106
07AnimalAnimal study (in vivo)Efficacy outcome
In dogs receiving t-PA, high-dose acadesine prolonged time to reocclusion versus saline.
In plain wordsIn dogs receiving t-PA, high-dose acadesine delayed repeat coronary blockage compared with saline.
Peptide
AICAR (acadesine)
Outcome
IncreaseTime to reocclusion, highest dose
Study
dogn: not reported in source
Coronary thrombolysis and reocclusion after t-PA
Comparator
Saline with t-PA
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
2.0 mg/kg/min · intravenousAs given in this study (dog).
Measurements
Time to reocclusion
80 min
2.0 mg/kg/min acadesine
Reported uncertainty
13 min
type not stated
Source sentences
Summary
At the highest dose (2.0 mg/kg/min) of acadesine, only 2 of 8 (25%) animals reoccluded (p < 0.05), and time to occlusion was prolonged to 80 +/- 13 min (p < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5, 1.0, 2.0 mg/kg/min, i.v.) on time reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 micrograms/kg/min, i.v.).
Report a problemFND-0860712107
08AnimalAnimal study (in vivo)Efficacy outcome
In dogs receiving t-PA, acadesine did not affect hemodynamics versus saline.
In plain wordsIn dogs receiving t-PA, acadesine did not change circulation measures compared with saline.
Peptide
AICAR (acadesine)
Outcome
No significant changeHemodynamics
Study
dogn: not reported in source
Coronary thrombolysis and reocclusion after t-PA
Comparator
Saline with t-PA
Outcome group
Heart function · Cardiovascular
Studied dose
0.5, 1.0, 2.0 mg/kg/min · intravenousAs given in this study (dog).
Source sentences
Summary
Acadesine had no effect on hemodynamics.
1 context sentence(design, population, supporting numbers)
Summary · context
In 4 groups of dogs we examined the effects of saline and 3 doses of acadesine (0.5, 1.0, 2.0 mg/kg/min, i.v.) on time reperfusion, and incidence and time to reocclusion following infusion of t-PA (10 micrograms/kg/min, i.v.).
Report a problemFND-0860712108

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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