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Study · Animal study (in vivo) · rat · 1996

3 results

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins.

Guan J, Williams CE, Skinner SJ, Mallard EC, Gluckman PD

Endocrinology1 Mar 1996Cited by 100 (Europe PMC)

PMID8603600 (opens in a new tab)DOI10.1210/endo.137.3.8603600 (opens in a new tab)PepBankPUB-08603600
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats after hypoxic-ischemic injury, 150 micrograms des-IGF-1 showed a trend toward reduced neuronal loss.

    In plain wordsIn rats after brain injury, 150 micrograms des-IGF-1 showed a trend toward less nerve cell loss.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseNeuronal loss
    Study

    ratn = 20

    Adult rats with hypoxic-ischemic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    150 micrograms · Lateral cerebral ventricleAs given in this study (rat).

    Source sentences

    Summary
    There was a trend towards a reduction in neuronal loss after 150 micrograms des-IGF-1 (n = 20).
    3 context sentences
    Summary · context
    To clarify the mode of action of IGF-1 and the potential role of IGFBPs, the effects of IGF-1, IGF-2, des(1-3)-N-IGF-1 (des-IGF-1), an analogue of IGF-1 with low affinity for IGFBPs, and IGF-1 combined with IGF-2 were compared 2 h after administration into the lateral cerebral ventricle after an HI injury.
    Summary · context
    Unilateral HI was induced in adult rats by right carotid artery ligation followed by 10- min exposure to 6%O2.
    Summary · context
    The extent of neuronal loss was determined in the cortex, striatum, hippocampus, dentate gyrus, and thalamus 5 days later.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats after hypoxic-ischemic injury, 20 micrograms des-IGF-1 did not reduce neuronal loss.

    In plain wordsIn rats after brain injury, 20 micrograms des-IGF-1 did not reduce nerve cell loss.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeNeuronal loss
    Study

    ratn = 17

    Adult rats with hypoxic-ischemic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 micrograms · Lateral cerebral ventricleAs given in this study (rat).

    Source sentences

    Summary
    Neither 20 micrograms IGF-2 (n = 17), 2 micrograms des-IGF-1 (n = 10), nor 20 micrograms des-IGF-1 (n = 17) reduced neuronal loss.
    3 context sentences
    Summary · context
    To clarify the mode of action of IGF-1 and the potential role of IGFBPs, the effects of IGF-1, IGF-2, des(1-3)-N-IGF-1 (des-IGF-1), an analogue of IGF-1 with low affinity for IGFBPs, and IGF-1 combined with IGF-2 were compared 2 h after administration into the lateral cerebral ventricle after an HI injury.
    Summary · context
    Unilateral HI was induced in adult rats by right carotid artery ligation followed by 10- min exposure to 6%O2.
    Summary · context
    The extent of neuronal loss was determined in the cortex, striatum, hippocampus, dentate gyrus, and thalamus 5 days later.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats after hypoxic-ischemic injury, 2 micrograms des-IGF-1 did not reduce neuronal loss.

    In plain wordsIn rats after brain injury, 2 micrograms des-IGF-1 did not reduce nerve cell loss.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeNeuronal loss
    Study

    ratn = 10

    Adult rats with hypoxic-ischemic brain injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2 micrograms · Lateral cerebral ventricleAs given in this study (rat).

    Source sentences

    Summary
    Neither 20 micrograms IGF-2 (n = 17), 2 micrograms des-IGF-1 (n = 10), nor 20 micrograms des-IGF-1 (n = 17) reduced neuronal loss.
    3 context sentences
    Summary · context
    To clarify the mode of action of IGF-1 and the potential role of IGFBPs, the effects of IGF-1, IGF-2, des(1-3)-N-IGF-1 (des-IGF-1), an analogue of IGF-1 with low affinity for IGFBPs, and IGF-1 combined with IGF-2 were compared 2 h after administration into the lateral cerebral ventricle after an HI injury.
    Summary · context
    Unilateral HI was induced in adult rats by right carotid artery ligation followed by 10- min exposure to 6%O2.
    Summary · context
    The extent of neuronal loss was determined in the cortex, striatum, hippocampus, dentate gyrus, and thalamus 5 days later.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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