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Study · In vitro (cells) · 1996

1 result

Characterization of insulin-like growth factor-I and its receptor and binding proteins in transected nerves and cultured Schwann cells.

Cheng HL, Randolph A, Yee D, Delafontaine P, Tennekoon G, Feldman EL

Journal of neurochemistry1 Feb 1996Cited by 87 (Europe PMC)

PMID8592122 (opens in a new tab)DOI10.1046/j.1471-4159.1996.66020525.x (opens in a new tab)PepBankPUB-08592122
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured Schwann cells, Des(1‑3)IGF-I did not increase IGFBP-5 intensity as IGF-I did.

    In plain wordsIn cells, Des(1‑3)IGF-I did not increase IGFBP-5 intensity as IGF-I did.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeIGFBP-5 intensity
    Study

    n: not reported in source

    Cultured Schwann cells
    Comparator
    IGF-I treatment
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3)IGF-I, an IGF-I analogue with low affinity for IGFBP, had no such effect.
    1 context sentence
    Summary · context
    IGF-I treatment increased the intensity of IGFBP-5 without affecting gene expression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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