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Study · Ex vivo tissue · rat · 1995

2 results

The involvement of dipeptidyl peptidase IV in brush-border degradation of GRF(1-29)NH2 by intestinal mucosal cells.

Bai JP, Chang LL

The Journal of pharmacy and pharmacology1 Aug 1995Cited by 2 (Europe PMC)

PMID8583376 (opens in a new tab)DOI10.1111/j.2042-7158.1995.tb05863.x (opens in a new tab)PepBankPUB-08583376
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat intestinal brush-border membranes, GRF(3-29)NH2 was the major metabolite of GRF(1-29)NH2, formed by the action of DPP IV.

    In plain wordsIn lab tests on rat gut membranes, the enzyme DPP IV broke GRF(1-29)NH2 down mainly into GRF(3-29)NH2.

    Peptide
    Sermorelin
    Outcome
    Not applicableMajor metabolite of GRF(1-29)NH2 in brush-border membranes
    Study

    ratn: not reported in source

    Intestinal brush-border membrane and homogenate
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Gradient HPLC analysis, mass balance analysis and studies of inhibitor effects revealed that GRF(3-29)NH2 was the major metabolite of GRF(1-29)NH2 due to the action of DPP IV during incubation with brush-border membranes.
    1 context sentence
    Summary · context
    stability of GRF(1-29)NH2 and [desNH2Tyr1,D-Ala2,Ala15]-GRF(1-29)NH2 in rat intestine brush-border membrane and homogenate
  2. 02LabEx vivo tissuePharmacokinetics

    In rat intestinal brush-border membrane and homogenate, GRF(1-29)NH2 was much less stable than the plasma DPP IV-resistant analog [desNH2Tyr1,D-Ala2,Ala15]-GRF(1-29)NH2.

    In plain wordsIn lab tests on rat gut tissue, GRF(1-29)NH2 broke down much faster than a modified version resistant to the enzyme DPP IV.

    Peptide
    Sermorelin
    Outcome
    DecreaseStability of GRF(1-29)NH2 in enterocytes compared with a DPP IV-resistant analog
    Study

    ratn: not reported in source

    Intestinal brush-border membrane and homogenate
    Comparator
    [desNH2Tyr1,D-Ala2,Ala15]-GRF(1-29)NH2
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    [desNH2Tyr1,D-Ala2,Ala15]-GRF(1-29)NH2, resistant to plasma DPP IV, was much more stable than GRF(1-29)NH2 in enterocytes.
    1 context sentence
    Summary · context
    stability of GRF(1-29)NH2 and [desNH2Tyr1,D-Ala2,Ala15]-GRF(1-29)NH2 in rat intestine brush-border membrane and homogenate

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

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