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Study · Non-randomized trial · n = 6 · 1995

8 results

Bioavailability and pharmacokinetics of sublingual oxytocin in male volunteers.

De Groot AN, Vree TB, Hekster YA, Pesman GJ, Sweep FC, Van Dongen PJ, Van Roosmalen J

The Journal of pharmacy and pharmacology1 Jul 1995Cited by 28 (Europe PMC)

PMID8568623 (opens in a new tab)DOI10.1111/j.2042-7158.1995.tb06716.x (opens in a new tab)PepBankPUB-08568623
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In six male volunteers, the distribution half-life of intravenous oxytocin was 0.049 h.

    In plain wordsIn six men, oxytocin given into a vein spread out of the blood in a very short time.

    Peptide
    Oxytocin
    Outcome
    Not applicableDistribution half-life after intravenous dose
    Study

    n = 6

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 int. unit (1.71 micrograms) · intravenousAs given in this study (human).

    Measurements

    Distribution half-life
    0.049 h
    intravenous

    Source sentences

    Summary
    The distribution half-life was 0.049 +/- 0.106 h
    1 context sentence
    Summary · context
    The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms).
  2. 02HumanNon-randomized trialPharmacokinetics

    In six male volunteers, the elimination half-life of intravenous oxytocin was 0.33 h.

    In plain wordsIn six men, oxytocin given into a vein was cleared from the body with a half-life of 0.33 hours.

    Peptide
    Oxytocin
    Outcome
    Not applicableElimination half-life after intravenous dose
    Study

    n = 6

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 int. unit (1.71 micrograms) · intravenousAs given in this study (human).

    Measurements

    Elimination half-life
    0.33 h
    intravenous

    Source sentences

    Summary
    the elimination half-life was 0.33 +/- 0.23 h
    1 context sentence
    Summary · context
    The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms).
  3. 03HumanNon-randomized trialPharmacokinetics

    In six male volunteers, the total body clearance of intravenous oxytocin was 67.1 L per hour.

    In plain wordsIn six men, the body cleared oxytocin given into a vein at 67.1 litres per hour.

    Peptide
    Oxytocin
    Outcome
    Not applicableTotal body clearance after intravenous dose
    Study

    n = 6

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 int. unit (1.71 micrograms) · intravenousAs given in this study (human).

    Measurements

    Total body clearance
    67.1 L h-1
    intravenous

    Source sentences

    Summary
    the total body clearance was 67.1 +/- 13.4 L h-1
    1 context sentence
    Summary · context
    The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms).
  4. 04HumanNon-randomized trialPharmacokinetics

    In six male volunteers, the volume of distribution of intravenous oxytocin was 33.2 L.

    In plain wordsIn six men, oxytocin given into a vein spread into a volume of 33.2 litres.

    Peptide
    Oxytocin
    Outcome
    Not applicableVolume of distribution after intravenous dose
    Study

    n = 6

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    1 int. unit (1.71 micrograms) · intravenousAs given in this study (human).

    Measurements

    Volume of distribution
    33.2 L
    intravenous

    Source sentences

    Summary
    the volume of distribution was 33.2 +/- 28.1 L
    1 context sentence
    Summary · context
    The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms).
  5. 05HumanNon-randomized trialPharmacokinetics

    In six male volunteers, the bioavailability of sublingual oxytocin was poor, between 0.007 and 0.07%, with a 10-fold variation.

    In plain wordsIn six men, very little oxytocin placed under the tongue reached the blood, and the amount varied a lot between men.

    Peptide
    Oxytocin
    Outcome
    Not applicableSublingual bioavailability
    Study

    n = 6

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    400 int. units (684 micrograms) · sublingualAs given in this study (human).

    Measurements

    Bioavailability
    0.007 to 0.07%
    sublingual

    Source sentences

    Summary
    After sublingual administration, a poor bioavailability with a 10-fold variation between 0.007 and 0.07% was observed.
    1 context sentence
    Summary · context
    The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms).
  6. 06HumanNon-randomized trialPharmacokinetics

    In six male volunteers, the lag time of sublingual oxytocin ranged between 0.12 and 0.30 h and differed between subjects.

    In plain wordsIn six men, oxytocin under the tongue took 0.12 to 0.30 hours to start entering the blood, depending on the man.

    Peptide
    Oxytocin
    Outcome
    Not applicableLag time after sublingual dose
    Study

    n = 6

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    400 int. units (684 micrograms) · sublingualAs given in this study (human).

    Measurements

    Lag time
    0.12 to 0.3 h
    sublingual

    Source sentences

    Summary
    The lag time was subject-dependent and ranged between 0.12 and 0.30 h (40% CV).
    1 context sentence
    Summary · context
    The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms).
  7. 07HumanNon-randomized trialPharmacokinetics

    In six male volunteers, the absorption half-life of sublingual oxytocin was 0.45 h.

    In plain wordsIn six men, oxytocin under the tongue was absorbed slowly, with a half-life of 0.45 hours.

    Peptide
    Oxytocin
    Outcome
    Not applicableAbsorption half-life after sublingual dose
    Study

    n = 6

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    400 int. units (684 micrograms) · sublingualAs given in this study (human).

    Measurements

    Absorption half-life
    0.45 h
    sublingual

    Source sentences

    Summary
    The absorption half-life was 0.45 +/- 0.29 h
    1 context sentence
    Summary · context
    The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms).
  8. 08HumanNon-randomized trialPharmacokinetics

    In six male volunteers, the apparent elimination half-life after sublingual oxytocin was 0.69 h.

    In plain wordsIn six men, after oxytocin under the tongue, the apparent elimination half-life was 0.69 hours.

    Peptide
    Oxytocin
    Outcome
    Not applicableApparent elimination half-life after sublingual dose
    Study

    n = 6

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    400 int. units (684 micrograms) · sublingualAs given in this study (human).

    Measurements

    Apparent elimination half-life
    0.69 h
    sublingual

    Source sentences

    Summary
    the apparent elimination half-life 0.69 +/ - 0.26 h.
    1 context sentence
    Summary · context
    The aim of this investigation was to assess the bioavailability and pharmacokinetics of oxytocin in six male subjects after a sublingual dose of 400 int. units (684 micrograms) and after an intravenous dose of 1 int. unit (1.71 micrograms).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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