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Study · Ex vivo tissue · rat · 1995

4 results

Brain tissue hydrolysate acts on presynaptic adenosine receptors in the rat hippocampus.

Xiong H, Wojtowicz JM, Baskys A

Canadian journal of physiology and pharmacology1 Aug 1995Cited by 13 (Europe PMC)

PMID8564889 (opens in a new tab)DOI10.1139/y95-170 (opens in a new tab)PepBankPUB-08564889
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat hippocampal slices, Cerebrolysin depressed synaptic transmission at the Schaffer collateral-commissural pathway in CA1.

    In plain wordsIn lab tests with rat brain slices, Cerebrolysin reduced synaptic transmission in CA1.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseSynaptic transmission
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 area
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A major effect of the drug at doses approximating those administered clinically to demented patients was a depression of synaptic transmission at the Schaffer collateral-commissural pathway in CA1.
    1 context sentence
    Summary · context
    In this study we have examined the effects of a clinically used porcine brain tissue hydrolysate, Cerebrolysin, on synaptic transmission in the CA1 area of rat hippocampal slices.
  2. 02LabEx vivo tissueMechanism

    In rat hippocampal slices, Cerebrolysin-induced inhibition of synaptic transmission was presynaptic.

    In plain wordsIn lab tests with rat brain slices, Cerebrolysin inhibited transmission at the presynaptic site.

    Peptide
    Cerebrolysin
    Outcome
    Not applicablePresynaptic site of inhibition
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 area
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Detailed analysis showed that the inhibition is presynaptic and can be reduced by low doses of a specific blocker of adenosine A1 receptors, 8-cyclopentyltheophylline.
    1 context sentence
    Summary · context
    In this study we have examined the effects of a clinically used porcine brain tissue hydrolysate, Cerebrolysin, on synaptic transmission in the CA1 area of rat hippocampal slices.

Studies that did not test the peptide alone2

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

  1. 03LabNot a test of Cerebrolysin aloneEx vivo tissueMechanism

    In rat hippocampal slices, the adenosine A1 receptor blocker 8-cyclopentyltheophylline reduced Cerebrolysin-induced inhibition.

    In plain wordsIn lab tests with rat brain slices, an adenosine receptor blocker reduced Cerebrolysin-induced inhibition.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAdenosine A1 receptor blockade of synaptic inhibition
    Study

    ratn: not reported in source

    Hippocampal slices, CA1 area
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Detailed analysis showed that the inhibition is presynaptic and can be reduced by low doses of a specific blocker of adenosine A1 receptors, 8-cyclopentyltheophylline.
    1 context sentence
    Summary · context
    In this study we have examined the effects of a clinically used porcine brain tissue hydrolysate, Cerebrolysin, on synaptic transmission in the CA1 area of rat hippocampal slices.

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

  2. 04LabNot a test of Cerebrolysin aloneIn vitro (cell-free)Activity measurement

    In the Cerebrolysin preparation, adenosine was not detectable.

    In plain wordsIn lab tests, the Cerebrolysin preparation contained no detectable adenosine.

    Peptide
    Cerebrolysin
    Outcome
    Not applicableDetectable adenosine content
    Study

    n: not reported in source

    Cerebrolysin preparation
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Because Cerebrolysin does not contain a detectable amount of adenosine,

    In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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