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Study · Animal study (in vivo) · rat · 1995

3 results

[Changes in the content of substance P, beta-endorphin and corticosterone in the hypothalamus and blood of rats with emotional stress after the administration of the delta sleep-inducing peptide].

Sudakov KV, Coghlan JP, Kotov AV, Salieva RM, Polyntsev IuV, Koplik EV

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 Sept 1995Cited by 2 (Europe PMC)

PMID8560945 (opens in a new tab)PepBankPUB-08560945
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Wistar and August rats under emotional stress, DSIP administration induced marked changes in substance P levels in the hypothalamus and blood plasma.

    In plain wordsIn rats under stress, DSIP markedly changed substance P levels in the brain and blood. The abstract gives no direction.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedSubstance P in hypothalamus and plasma
    Study

    ratn: not reported in source

    emotional stress
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    60 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    Our experiments showed that DSIP administration induced marked changes in SP, BE, and CORT levels in the hypothalamus and blood plasma.
    1 context sentence
    Summary · context
    Experiments were carried out in male Wistar and August rats with different resistance to emotional stress.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Wistar and August rats under emotional stress, DSIP administration induced marked changes in beta-endorphin levels in the hypothalamus and blood plasma.

    In plain wordsIn rats under stress, DSIP markedly changed beta-endorphin levels in the brain and blood. The abstract gives no direction.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedBeta-endorphin in hypothalamus and plasma
    Study

    ratn: not reported in source

    emotional stress
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    60 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    Our experiments showed that DSIP administration induced marked changes in SP, BE, and CORT levels in the hypothalamus and blood plasma.
    1 context sentence
    Summary · context
    Experiments were carried out in male Wistar and August rats with different resistance to emotional stress.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In Wistar and August rats under emotional stress, DSIP administration induced marked changes in corticosterone levels in the hypothalamus and blood plasma.

    In plain wordsIn rats under stress, DSIP markedly changed corticosterone (a stress hormone) levels in the brain and blood. The abstract gives no direction.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Direction not reportedCorticosterone in hypothalamus and plasma
    Study

    ratn: not reported in source

    emotional stress
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    60 nmol/kgAs given in this study (rat).

    Source sentences

    Summary
    Our experiments showed that DSIP administration induced marked changes in SP, BE, and CORT levels in the hypothalamus and blood plasma.
    1 context sentence
    Summary · context
    Experiments were carried out in male Wistar and August rats with different resistance to emotional stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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