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Study · In vitro (cells) · 1995

3 results

Brain-derived peptides regulate the steady state levels and increase stability of the blood-brain barrier GLUT1 glucose transporter mRNA.

Boado RJ

Neuroscience letters1 Sept 1995Cited by 23 (Europe PMC)

PMID8552293 (opens in a new tab)DOI10.1016/0304-3940(95)11930-u (opens in a new tab)PepBankPUB-08552293
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured brain capillary endothelial cells, Cerebrolysin transiently increased BBB-GLUT1 transcript abundance relative to actin during the first 2 h.

    In plain wordsIn cells, Cerebrolysin briefly increased the glucose transporter transcript relative to actin during the first 2 h.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseEarly BBB-GLUT1 transcript abundance
    Study

    n: not reported in source

    Cultured brain capillary endothelial cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · first 2 h of incubationAs given in this study.

    Source sentences

    Summary
    In cultures of brain capillary endothelial cells, Cl induced a transient increase in the abundance of BBB-GLUT1 relative to actin measured by reverse transcription-polymerase chain reaction during the first 2 h of incubation, whereas a significant reduction in the GLUT1 transcript was observed at 20 and 48 h.
    1 context sentence
    Summary · context
    Therefore, the present study investigated the effect of a brain-derived peptide rich preparation containing a neurotrophic factor-like action [Cerebrolysin (Cl), EBEWE, Austria].
  2. 02LabIn vitro (cells)Mechanism

    In cultured brain capillary endothelial cells, Cerebrolysin significantly reduced GLUT1 transcript abundance at 20 and 48 h.

    In plain wordsIn cells, Cerebrolysin reduced the glucose transporter transcript at 20 and 48 h.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseLate GLUT1 transcript abundance
    Study

    n: not reported in source

    Cultured brain capillary endothelial cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · 20 and 48 hAs given in this study.

    Source sentences

    Summary
    In cultures of brain capillary endothelial cells, Cl induced a transient increase in the abundance of BBB-GLUT1 relative to actin measured by reverse transcription-polymerase chain reaction during the first 2 h of incubation, whereas a significant reduction in the GLUT1 transcript was observed at 20 and 48 h.
    1 context sentence
    Summary · context
    Therefore, the present study investigated the effect of a brain-derived peptide rich preparation containing a neurotrophic factor-like action [Cerebrolysin (Cl), EBEWE, Austria].
  3. 03LabIn vitro (cells)Mechanism

    In cultured brain capillary endothelial cells, Cerebrolysin abolished the fall in GLUT1 levels induced by actinomycin D.

    In plain wordsIn cells, Cerebrolysin prevented the fall in glucose transporter levels caused by actinomycin D.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseActinomycin D-induced GLUT1 loss
    Study

    n: not reported in source

    Cultured brain capillary endothelial cells
    Comparator
    Actinomycin D
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, Cl abolished the fall in GLUT1 levels induced by actinomycin D.
    1 context sentence
    Summary · context
    Therefore, the present study investigated the effect of a brain-derived peptide rich preparation containing a neurotrophic factor-like action [Cerebrolysin (Cl), EBEWE, Austria].

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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