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Study · Ex vivo tissue · guinea pig · 1995

7 results

Relaxant effects of pituitary adenylate cyclase activating polypeptide (PACAP) on epithelium-intact and -denuded guinea-pig trachea: a comparison with vasoactive intestinal peptide (VIP).

Conroy DM, St-Pierre S, Sirois P

Neuropeptides1 Sept 1995Cited by 13 (Europe PMC)

PMID8538872 (opens in a new tab)DOI10.1016/0143-4179(95)90013-6 (opens in a new tab)PepBankPUB-08538872
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In epithelium-intact guinea-pig tracheal strips, VIP was about three times more potent than PACAP in relaxing the tissue.

    In plain wordsIn guinea-pig windpipe tissue, VIP relaxed the muscle with about three times the potency of PACAP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableTracheal relaxation potency versus PACAP
    Study

    guinea pign: not reported in source

    isolated tracheal strips
    Comparator
    PACAP
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PACAP was approximately three times less potent than either VIP or salbutamol in relaxing epithelium-intact GPT.
    1 context sentence
    Summary · context
    The effect of pituitary adenylate cyclase activating peptide (PACAP 1-27) was examined on epithelium-intact and -denuded guinea-pig tracheal strips (GPT) and compared to vasoactive intestinal peptide (VIP) and salbutamol.
  2. 02LabEx vivo tissueMechanism

    In guinea-pig tracheal strips, the relaxant effect of VIP was markedly attenuated after removal of the epithelial layer.

    In plain wordsIn guinea-pig windpipe tissue, VIP relaxed the muscle much less after the lining layer was removed.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP relaxation after removal of the epithelium
    Study

    guinea pign: not reported in source

    isolated tracheal strips
    Comparator
    Epithelium-intact strips
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The relaxant effects of both peptides and salbutamol were markedly attenuated following removal of the epithelial layer.
    1 context sentence
    Summary · context
    The effect of pituitary adenylate cyclase activating peptide (PACAP 1-27) was examined on epithelium-intact and -denuded guinea-pig tracheal strips (GPT) and compared to vasoactive intestinal peptide (VIP) and salbutamol.
  3. 03LabEx vivo tissueEfficacy outcome

    In the guinea-pig upper bronchus, VIP induced relaxation.

    In plain wordsIn guinea-pig airway tissue, VIP relaxed the muscle of the upper bronchus.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseRelaxation of the upper bronchus
    Study

    guinea pign: not reported in source

    isolated upper bronchus
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PACAP and VIP also induced relaxations of the guinea-pig upper bronchus.
    1 context sentence
    Summary · context
    The effect of pituitary adenylate cyclase activating peptide (PACAP 1-27) was examined on epithelium-intact and -denuded guinea-pig tracheal strips (GPT) and compared to vasoactive intestinal peptide (VIP) and salbutamol.
  4. 04LabEx vivo tissueEfficacy outcome

    In chopped guinea-pig lung, VIP significantly inhibited the release of TxB2 induced by LTD4.

    In plain wordsIn guinea-pig lung tissue, VIP reduced the release of TxB2 that LTD4 triggered.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseLTD4-induced TxB2 release from lung
    Study

    guinea pign: not reported in source

    chopped lung
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    PACAP (10(-6) M), as well as VIP, significantly inhibited the release of TxB2 induced by LTD4 (10(-7) M) from chopped guinea-pig lung
    1 context sentence
    Summary · context
    The effect of pituitary adenylate cyclase activating peptide (PACAP 1-27) was examined on epithelium-intact and -denuded guinea-pig tracheal strips (GPT) and compared to vasoactive intestinal peptide (VIP) and salbutamol.

Studies that did not test the peptide alone3

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  1. 05LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism

    In guinea-pig tracheal strips, the nitric oxide synthase inhibitor L-NAME did not change the responses induced by VIP, so the relaxation does not depend on nitric oxide synthesis.

    In plain wordsIn guinea-pig windpipe tissue, blocking nitric oxide production with L-NAME did not change the response to VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeEffect of L-NAME on VIP-induced responses
    Study

    guinea pign: not reported in source

    isolated tracheal strips
    Comparator
    No L-NAME
    Outcome group
    Respiratory function · Respiratory

    Source sentences

    Summary
    L-NAME (10(-4) M), a nitric oxide synthase inhibitor, did not affect the responses induced by either PACAP or VIP demonstrating that the relaxant effect is independent of nitric oxide synthesis.
    1 context sentence
    Summary · context
    The effect of pituitary adenylate cyclase activating peptide (PACAP 1-27) was examined on epithelium-intact and -denuded guinea-pig tracheal strips (GPT) and compared to vasoactive intestinal peptide (VIP) and salbutamol.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  2. 06LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism

    In epithelium-intact guinea-pig tracheal strips, phosphoramidon increased the relaxant responses to VIP.

    In plain wordsIn guinea-pig windpipe tissue with its lining, phosphoramidon made the relaxing response to VIP stronger.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseEffect of phosphoramidon on VIP relaxation in epithelium-intact strips
    Study

    guinea pign: not reported in source

    isolated tracheal strips
    Comparator
    No phosphoramidon
    Outcome group
    Respiratory function · Respiratory

    Source sentences

    Summary
    Phosphoramidon (5 x 10(-6) M) potentiated the relaxant responses of epithelium-intact GPT to both PACAP and VIP but did not affect the responses of epithelium-denuded GPT.
    1 context sentence
    Summary · context
    The effect of pituitary adenylate cyclase activating peptide (PACAP 1-27) was examined on epithelium-intact and -denuded guinea-pig tracheal strips (GPT) and compared to vasoactive intestinal peptide (VIP) and salbutamol.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  3. 07LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism

    In epithelium-denuded guinea-pig tracheal strips, phosphoramidon did not change the responses to VIP.

    In plain wordsIn guinea-pig windpipe tissue without its lining, phosphoramidon did not change the response to VIP.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeEffect of phosphoramidon on VIP relaxation in epithelium-denuded strips
    Study

    guinea pign: not reported in source

    isolated tracheal strips
    Comparator
    No phosphoramidon
    Outcome group
    Respiratory function · Respiratory

    Source sentences

    Summary
    Phosphoramidon (5 x 10(-6) M) potentiated the relaxant responses of epithelium-intact GPT to both PACAP and VIP but did not affect the responses of epithelium-denuded GPT.
    1 context sentence
    Summary · context
    The effect of pituitary adenylate cyclase activating peptide (PACAP 1-27) was examined on epithelium-intact and -denuded guinea-pig tracheal strips (GPT) and compared to vasoactive intestinal peptide (VIP) and salbutamol.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

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