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Study · Ex vivo tissue · 1995

4 results

Thymosin alpha-1 and FA-1 monoclonal antibody affect fertilizing capacity of human sperm by modulating protein phosphorylation pattern.

Ahmad K, Naz RK

Journal of reproductive immunology1 May 1995Cited by 4 (Europe PMC)

PMID8531188 (opens in a new tab)DOI10.1016/0165-0378(95)00932-b (opens in a new tab)PepBankPUB-08531188
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In human sperm, thymosin alpha‑1 enhanced phosphorylation of 7 membrane proteins in 32P metabolic labeling experiments.

    In plain wordsIn lab tests with human sperm, thymosin alpha‑1 increased phosphorylation of seven sperm proteins.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePhosphorylation of sperm proteins (32P labeling)
    Study

    humann: not reported in source

    Human sperm during capacitation
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    0.25 and 0.5 microgram/100 microlitersAs given in this study (human).

    Measurements

    Proteins with enhanced phosphorylation
    7 proteins
    32P labeling

    Source sentences

    Summary
    T alpha 1 (0.25 and 0.5 microgram/100 microliters) enhanced phosphorylation of 7 proteins
  2. 02LabEx vivo tissueMechanism

    In extracts of non-capacitated human sperm, thymosin alpha‑1 enhanced autophosphorylation of 14 proteins.

    In plain wordsIn lab tests with human sperm extracts, thymosin alpha‑1 increased self-phosphorylation of 14 proteins.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseAutophosphorylation in non-capacitated sperm extracts
    Study

    humann: not reported in source

    Human sperm during capacitation
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    0.5 microgram/100 microlitersAs given in this study (human).

    Measurements

    Proteins with enhanced autophosphorylation
    14 proteins
    non-capacitated sperm extract

    Source sentences

    Summary
    T alpha 1 (0.5 microgram/100 microliters) enhanced autophosphorylation of 14 proteins
  3. 03LabEx vivo tissueMechanism

    In extracts of capacitated human sperm, thymosin alpha‑1 at the same concentration did not affect autophosphorylation of proteins.

    In plain wordsIn lab tests with capacitated human sperm extracts, thymosin alpha‑1 did not change protein self-phosphorylation.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeAutophosphorylation in capacitated sperm extracts
    Study

    humann: not reported in source

    Human sperm during capacitation
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    0.5 microgram/100 microlitersAs given in this study (human).

    Source sentences

    Summary
    The same concentration of T alpha 1 did not affect autophosphorylation of proteins in capacitated sperm extract.
  4. 04LabEx vivo tissueMechanism

    In human sperm during capacitation, thymosin alpha‑1 produced a concentration-dependent increase in tyrosine phosphorylation of two proteins (95 and 51 kDa).

    In plain wordsIn lab tests with human sperm, thymosin alpha‑1 increased tyrosine phosphorylation of two proteins, more at higher concentrations.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseTyrosine phosphorylation of 95 and 51 kDa proteins
    Study

    humann: not reported in source

    Human sperm during capacitation
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    T alpha 1 resulted in a concentration-dependent increase in tyrosine phosphorylation of two proteins (95 and 51 kDa) during capacitation of human sperm

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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