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Study · Measured the body's own peptide · 1993

11 results

Oxytocin gene expression and action in bovine preovulatory follicles.

Fortune JE, Voss AK

Regulatory peptides1 Apr 1993Cited by 3 (Europe PMC)

PMID8511353 (opens in a new tab)DOI10.1016/0167-0115(93)90216-u (opens in a new tab)PepBankPUB-08511353
Publisher pagePubMedAsk about this study
Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Natural levels measured11

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelEx vivo tissueMechanism

    In bovine granulosa cells, oxytocin content was much higher in cells obtained after the LH surge than before it.

    In plain wordsIn cow follicle cells, the body's own oxytocin content was much higher after the LH surge.

    Peptide
    Oxytocin
    Outcome
    IncreaseGranulosa cell oxytocin content after LH surge
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Both OT content of granulosa cells and their ability to secrete OT in culture increased dramatically when follicles were obtained after the gonadotropin surge (LH surge) that triggers ovulation.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelEx vivo tissueMechanism

    In bovine granulosa cells, the ability to secrete oxytocin in culture was much higher in cells obtained after the LH surge.

    In plain wordsIn cow follicle cells, release of the body's own oxytocin in lab culture was much higher after the LH surge.

    Peptide
    Oxytocin
    Outcome
    IncreaseGranulosa cell oxytocin secretion in culture after LH surge
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Both OT content of granulosa cells and their ability to secrete OT in culture increased dramatically when follicles were obtained after the gonadotropin surge (LH surge) that triggers ovulation.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelEx vivo tissueMechanism

    In bovine granulosa cells, oxytocin mRNA levels were higher after the LH surge than before it.

    In plain wordsIn cow follicle cells, gene activity for the body's own oxytocin was higher after the LH surge.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin mRNA in granulosa cells after LH surge
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    These changes were correlated with increased levels of messenger RNA (mRNA) for OT in granulosa cells obtained after vs. before the LH surge.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    In bovine preovulatory follicles, granulosa cells secreted their own oxytocin in vitro but theca cells did not.

    In plain wordsIn cow follicle cells, granulosa cells made and released the body's own oxytocin in the lab but theca cells did not.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin secretion by granulosa versus theca cells
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    OT is secreted in vitro by follicular granulosa cells, but not by theca cells.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05LabEndogenous levelIn vitro (cells)Mechanism

    In cultured bovine granulosa cells obtained before the LH surge, oxytocin secretion increased with time in culture.

    In plain wordsIn cultured cow follicle cells, release of the body's own oxytocin rose over time in the lab.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin secretion over time in culture
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    When granulosa cells were obtained before the surge, both OT secretion and OT mRNA levels increased with time in culture, and the increases were greatly enhanced in the presence of LH.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06LabEndogenous levelIn vitro (cells)Mechanism

    In cultured bovine granulosa cells obtained before the LH surge, oxytocin mRNA levels increased with time in culture.

    In plain wordsIn cultured cow follicle cells, gene activity for the body's own oxytocin rose over time in the lab.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin mRNA over time in culture
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    When granulosa cells were obtained before the surge, both OT secretion and OT mRNA levels increased with time in culture, and the increases were greatly enhanced in the presence of LH.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  7. 07LabEndogenous levelIn vitro (cells)Mechanism

    In cultured bovine granulosa cells, LH greatly enhanced the increase in oxytocin secretion.

    In plain wordsIn cultured cow follicle cells, LH strongly increased release of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseEffect of LH on oxytocin secretion
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    When granulosa cells were obtained before the surge, both OT secretion and OT mRNA levels increased with time in culture, and the increases were greatly enhanced in the presence of LH.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  8. 08LabEndogenous levelIn vitro (cells)Mechanism

    In cultured bovine granulosa cells, LH greatly enhanced the increase in oxytocin mRNA levels.

    In plain wordsIn cultured cow follicle cells, LH strongly increased gene activity for the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseEffect of LH on oxytocin mRNA
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    When granulosa cells were obtained before the surge, both OT secretion and OT mRNA levels increased with time in culture, and the increases were greatly enhanced in the presence of LH.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  9. 09LabEndogenous levelIn vitro (cells)Mechanism

    In cultured bovine granulosa cells, estradiol at pre-LH-surge follicular fluid concentrations inhibited oxytocin secretion.

    In plain wordsIn cultured cow follicle cells, estradiol at pre-surge levels reduced release of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    DecreaseEffect of pre-surge estradiol on oxytocin secretion
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Estradiol, at concentrations found in follicular fluid of preovulatory follicles before the LH surge, inhibited OT secretion in vitro, whereas concentrations found in follicular fluid after the LH surge were not inhibitory.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  10. 10LabEndogenous levelIn vitro (cells)Mechanism

    In cultured bovine granulosa cells, estradiol at post-LH-surge concentrations did not inhibit oxytocin secretion.

    In plain wordsIn cultured cow follicle cells, estradiol at post-surge levels did not reduce release of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeEffect of post-surge estradiol on oxytocin secretion
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Estradiol, at concentrations found in follicular fluid of preovulatory follicles before the LH surge, inhibited OT secretion in vitro, whereas concentrations found in follicular fluid after the LH surge were not inhibitory.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  11. 11LabEndogenous levelIn vitro (cells)Mechanism

    In cultured bovine granulosa cells, progesterone at physiological concentrations stimulated oxytocin secretion.

    In plain wordsIn cultured cow follicle cells, progesterone increased release of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseEffect of progesterone on oxytocin secretion
    Study

    cattlen: not reported in source

    bovine preovulatory follicle granulosa cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Progesterone, at physiological concentrations, stimulated OT secretion in vitro.
    1 context sentence
    Summary · context
    We have studied oxytocin (OT) gene expression, secretion, and action in bovine preovulatory follicles during the follicular phase of the estrous cycle.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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