Regulation of His-dTrp-Ala-Trp-dPhe-Lys-NH2 (GHRP-6)-induced GH secretion in the rat.

Mallo F, Mallo F, Alvarez CV, Benitez L, Burguera B, Coya R, Casanueva FF, Dieguez C

Neuroendocrinology1 Jan 1993Cited by 28 (Europe PMC)

PMID8510800DOI10.1159/000126366PepBankPUB-08510800

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In hypophysectomized rats with transplanted pituitaries, GHRP‑6 directly stimulated GH secretion.
In plain wordsIn rats with transplanted pituitary glands, GHRP‑6 stimulated growth hormone release.
Peptide
GHRP-6
Outcome
IncreaseGH response in pituitary-transplanted rats
Study
ratn: not reported in source
Hypophysectomized-transplanted rats bearing two hypophyses under the renal capsule
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
A direct stimulatory effect of GHRP-6 on in vivo GH secretion was demonstrated by a clear GH response to GHRP-6 in hypophysectomyzed-transplanted rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Specifically and in order to avoid the influence of endogenous GHRH and somatostatin secretion we studied the GH responses to GHRP-6 in animals with surgical ablation of the hypothalamus, confirmed by histological assessment, as well as in hypophysectomyzed-transplanted rats bearing two hypophyses u…
Report a problemFND-0851080002
02AnimalAnimal study (in vivo)Mechanism
In rats, GH responses were similar after chronic GHRP‑6 or GHRH pretreatment.
In plain wordsIn rats, growth hormone responses were similar after repeated GHRP‑6 or GHRH treatment.
Peptide
GHRP-6
Outcome
No significant changeGH response after chronic pretreatment
Study
ratn: not reported in source
Pentobarbital-anesthetized rats
Comparator
GHRH pretreatment
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg every 12 h · intraperitoneal · 2 weeksAs given in this study (rat).
Source sentences
Summary
In addition, we found a similar response whether the animals were pretreated with GHRH or GHRP-6 over the previous 2 weeks.
1 context sentence(design, population, supporting numbers)
Summary · context
Since it has been previously reported that rats pretreated with GHRH (10 micrograms/kg i.p. every 12 h for 15 days) rather than saline-treated rats have greater GH responses to acutely administered GHRH, we compared the self-potentiating effect of chronic GH pretreatment with GHRP-6 (10 micrograms/kg i.p. every 12 h).
Report a problemFND-0851080003

Studies that did not test the peptide alone6

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In rats, hypothalamic ablation increased the GH response to GHRP‑6 versus sham surgery.
In plain wordsIn rats, GHRP‑6 produced a larger growth hormone response after hypothalamus removal than after sham surgery.
Peptide
GHRP-6
Outcome
IncreaseGH response after hypothalamic ablation
Study
ratn: not reported in source
Pentobarbital-anesthetized rats
Comparator
Sham-operated rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
We found a greater GH response to GHRP-6 in rats that underwent a surgical ablation of the hypothalamus 36 h prior to the test than in sham-operated rats.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0851080001
04AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In rats, estrogen treatment increased GH responses to GHRP‑6 versus untreated rats.
In plain wordsIn rats, estrogen increased growth hormone responses to GHRP‑6 compared with untreated rats.
Peptide
GHRP-6
Outcome
IncreaseEstrogen-modified GH response
Study
ratn: not reported in source
Pentobarbital-anesthetized rats
Comparator
Untreated rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Finally, we found that both estrogen- and testosterone-treated rats have greater GH responses to GHRP-6 than untreated rats.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0851080004
05AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In rats, testosterone treatment increased GH responses to GHRP‑6 versus untreated rats.
In plain wordsIn rats, testosterone increased growth hormone responses to GHRP‑6 compared with untreated rats.
Peptide
GHRP-6
Outcome
IncreaseTestosterone-modified GH response
Study
ratn: not reported in source
Pentobarbital-anesthetized rats
Comparator
Untreated rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Finally, we found that both estrogen- and testosterone-treated rats have greater GH responses to GHRP-6 than untreated rats.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0851080005
06AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In rats, chronic dexamethasone markedly inhibited GH responses to GHRP‑6.
In plain wordsIn rats, repeated dexamethasone reduced growth hormone responses to GHRP‑6.
Peptide
GHRP-6
Outcome
DecreaseDexamethasone-modified GH response
Study
ratn: not reported in source
Pentobarbital-anesthetized rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
On the other hand, chronic dexamethasone administration, acute elevation of circulating FFA levels and bombesin administration markedly inhibited GH responses to GHRP-6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0851080006
07AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In rats, acute elevation of circulating free fatty acids markedly inhibited GH responses to GHRP‑6.
In plain wordsIn rats, increased circulating free fatty acids reduced growth hormone responses to GHRP‑6.
Peptide
GHRP-6
Outcome
DecreaseFFA-modified GH response
Study
ratn: not reported in source
Pentobarbital-anesthetized rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
On the other hand, chronic dexamethasone administration, acute elevation of circulating FFA levels and bombesin administration markedly inhibited GH responses to GHRP-6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0851080007
08AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism
In rats, bombesin markedly inhibited GH responses to GHRP‑6.
In plain wordsIn rats, bombesin reduced growth hormone responses to GHRP‑6.
Peptide
GHRP-6
Outcome
DecreaseBombesin-modified GH response
Study
ratn: not reported in source
Pentobarbital-anesthetized rats
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
On the other hand, chronic dexamethasone administration, acute elevation of circulating FFA levels and bombesin administration markedly inhibited GH responses to GHRP-6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0851080008

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:59 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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