Skip to content

Study · Ex vivo tissue · rat · 1993

5 results

Characterization of the release and metabolism of delta sleep-inducing peptide (DSIP) in the rat brain.

Nakamura A, Nakanishi H, Shiomi H

Neuropeptides1 Mar 1993Cited by 1 (Europe PMC)

PMID8474631 (opens in a new tab)DOI10.1016/0143-4179(93)90076-m (opens in a new tab)PepBankPUB-08474631
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissuePharmacokinetics

    Incubation of DSIP with rat brain membrane degraded DSIP and liberated tryptophan, its N-terminal amino acid.

    In plain wordsIn lab tests, rat brain membranes broke DSIP down and released the amino acid tryptophan.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseDSIP degradation by rat brain membrane
    Study

    ratn: not reported in source

    brain membrane, slices and synaptosomes
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Incubation of DSIP with rat brain membrane resulted in the degradation of DSIP with liberation of tryptophan, an N-terminal amino acid of DSIP.
  2. 02LabEx vivo tissueMechanism

    Bestatin and puromycin, aminopeptidase inhibitors, significantly inhibited the degradation of DSIP and the release of tryptophan by rat brain membrane.

    In plain wordsIn lab tests, two enzyme blockers slowed the breakdown of DSIP by rat brain membranes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseDSIP degradation with aminopeptidase inhibitors
    Study

    ratn: not reported in source

    brain membrane, slices and synaptosomes
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Bestatin and puromycin, aminopeptidase inhibitors, significantly inhibited the degradation of DSIP and release of tryptophan.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03LabEndogenous levelEx vivo tissueMechanism

    High K+ depolarization significantly stimulated the release of immunoreactive DSIP-like substance from rat brain slices and synaptosomes.

    In plain wordsIn lab tests, depolarizing rat brain tissue made it release the body's own DSIP-like material.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseK+-evoked release of irDSIP from slices and synaptosomes
    Study

    ratn: not reported in source

    brain membrane, slices and synaptosomes
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition

    Source sentences

    Summary
    The releases of immunoreactive DSIP-like substance (irDSIP) from rat brain slices and synaptosomes were significantly stimulated by high K(+)-evoked depolarization.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 04LabEndogenous levelEx vivo tissueMechanism

    The released irDSIP coeluted with native DSIP on gel filtration chromatography.

    In plain wordsIn lab tests, the released DSIP-like material behaved like natural DSIP on a size-separation column.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableIdentity of released irDSIP
    Study

    ratn: not reported in source

    brain membrane, slices and synaptosomes
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition

    Source sentences

    Summary
    The released irDSIP was coeluted with native DSIP on gel filtration chromatography.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 05LabEndogenous levelEx vivo tissueMechanism

    High K+-evoked release of irDSIP did not show extracellular Ca2+ dependency.

    In plain wordsIn lab tests, release of the body's own DSIP-like material did not need calcium outside the cells.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCalcium dependence of K+-evoked irDSIP release
    Study

    ratn: not reported in source

    brain membrane, slices and synaptosomes
    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition

    Source sentences

    Summary
    High K(+)-evoked release of irDSIP did not show extracellular Ca(2+)-dependency.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.