Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity.

Cordido F, Peñalva A, Dieguez C, Casanueva FF

The Journal of clinical endocrinology and metabolism1 Apr 1993Cited by 84 (Europe PMC)

PMID8473389DOI10.1210/jcem.76.4.8473389PepBankPUB-08473389

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. 2 results from people.

01HumanNon-randomized trialEfficacy outcome
In obese subjects, GHRP‑6 produced a higher GH peak than GHRH.
In plain wordsIn obese people, GHRP‑6 produced a higher growth hormone peak than GHRH.
Peptide
GHRP-6
Outcome
IncreaseGH peak versus GHRH
Study
n: not reported in source
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
100 micrograms · intravenousAs given in this study (human).
Measurements
GH peak
15.7 micrograms/L
GHRP-6
GH peak
6.8 not stated
GHRH
Source sentences
Summary
In a group of obese patients, GHRP-6 induced GH secretion, with a GH peak (mean +/- SEM) of 15.7 +/- 4.4 micrograms/L and an area under the curve (AUC) of 674 +/- 187, which were larger than those after GHRH stimulation (6.8 +/- 1.1 and 412 +/- 71, respectively).
Report a problemFND-0847338901
02HumanNon-randomized trialEfficacy outcome
In obese subjects, GHRP‑6 produced a larger GH AUC than GHRH.
In plain wordsIn obese people, GHRP‑6 produced a larger total growth hormone response than GHRH.
Peptide
GHRP-6
Outcome
IncreaseGH AUC versus GHRH
Study
n: not reported in source
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
100 micrograms · intravenousAs given in this study (human).
Measurements
GH AUC
674 not stated
GHRP-6
GH AUC
412 not stated
GHRH
Source sentences
Summary
In a group of obese patients, GHRP-6 induced GH secretion, with a GH peak (mean +/- SEM) of 15.7 +/- 4.4 micrograms/L and an area under the curve (AUC) of 674 +/- 187, which were larger than those after GHRH stimulation (6.8 +/- 1.1 and 412 +/- 71, respectively).
Report a problemFND-0847338902

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

03HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In obese subjects, pyridostigmine increased the mean GH peak after GHRP‑6.
In plain wordsIn obese people, pyridostigmine increased the growth hormone peak after GHRP‑6.
Peptide
GHRP-6
Outcome
IncreasePyridostigmine-modified GH peak
Study
n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Mean GH peak
32.2 not stated
pyridostigmine before GHRP-6
Source sentences
Summary
Pyridostigmine administered 60 min before GHRP-6, increased both the mean GH peak (32.2 +/- 6.9) and the AUC (1413 +/- 537) after GHRP-6 administration.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0847338903
04HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In obese subjects, pyridostigmine increased GH AUC after GHRP‑6.
In plain wordsIn obese people, pyridostigmine increased the total growth hormone response after GHRP‑6.
Peptide
GHRP-6
Outcome
IncreasePyridostigmine-modified GH AUC
Study
n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
1413 not stated
pyridostigmine before GHRP-6
Source sentences
Summary
Pyridostigmine administered 60 min before GHRP-6, increased both the mean GH peak (32.2 +/- 6.9) and the AUC (1413 +/- 537) after GHRP-6 administration.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0847338904
05HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In obese subjects, combined GHRP‑6 and GHRH produced individual GH responses ranging from 14-86 micrograms/L.
In plain wordsIn obese people, combined GHRP‑6 and GHRH produced growth hormone responses of 14-86 micrograms/L.
Peptide
GHRP-6
Outcome
IncreaseCombined individual GH responses
Study
n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Individual GH response
14 to 86 micrograms/L
combined GHRP-6 and GHRH
Source sentences
Summary
In a separate group of subjects, the combined administration of GHRP-6 and GHRH induced a massive discharge of GH, with individual responses ranging from 14-86 micrograms/L.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0847338905
06HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In obese subjects, combined GHRP‑6 and GHRH produced a potentiated mean GH peak.
In plain wordsIn obese people, combined GHRP‑6 and GHRH produced an increased growth hormone peak.
Peptide
GHRP-6
Outcome
IncreaseCombined mean GH peak
Study
n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
Mean GH peak
42.2 not stated
GHRP-6 plus GHRH
Source sentences
Summary
GHRP-6 plus GHRH induced a mean GH peak of 42.2 +/- 10.9 and an AUC of 1894 +/- 784 (P < 0.05), clearly indicating a potentiating (synergic) action when the two compounds were administered together.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0847338906
07HumanNot a test of GHRP-6 aloneNon-randomized trialEfficacy outcome
In obese subjects, combined GHRP‑6 and GHRH produced a potentiated GH AUC.
In plain wordsIn obese people, combined GHRP‑6 and GHRH increased the total growth hormone response.
Peptide
GHRP-6
Outcome
IncreaseCombined GH AUC
Study
n: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
1894 not stated
GHRP-6 plus GHRH
Source sentences
Summary
GHRP-6 plus GHRH induced a mean GH peak of 42.2 +/- 10.9 and an AUC of 1894 +/- 784 (P < 0.05), clearly indicating a potentiating (synergic) action when the two compounds were administered together.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0847338907

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:59 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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