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Study · Non-randomized trial · 1993

3 results

Role of leuprolide acetate depot in hysteroscopic surgery: a controlled study.

Perino A, Chianchiano N, Petronio M, Cittadini E

Fertility and sterility1 Mar 1993Cited by 39 (Europe PMC)

PMID8458448 (opens in a new tab)DOI10.1016/s0015-0282(16)55790-2 (opens in a new tab)PepBankPUB-08458448
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with submucous fibroids or abnormal uterine bleeding, operating time, bleeding and distention medium decreased significantly after leuprolide versus controls.

    In plain wordsIn patients with fibroids or abnormal uterine bleeding, operating time, bleeding and distention medium requirements decreased after leuprolide versus controls.

    Peptide
    Leuprolide
    Outcome
    DecreaseOperating time, operative bleeding and distention medium
    Study

    n: not reported in source

    Comparator
    Controls
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In groups B and C there was a significant reduction in the operating time, bleeding during the operation, and the amount of distention medium required after LA depot administration, but no significant differences in surgical feasibility or efficacy were found in group A patients after treatment.
    2 context sentences
    Summary · context
    Prospective, comparative study.
    Summary · context
    One hundred ninety-three patients (114 pretreated with LA depot and 79 controls) who underwent hysteroscopic surgery for uterine septa (group A), submucous fibroids (group B), and abnormal uterine bleeding (group C).
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with uterine septa, surgical feasibility did not differ significantly after leuprolide versus controls.

    In plain wordsIn patients with uterine septa, surgical feasibility did not differ significantly between leuprolide and controls.

    Peptide
    Leuprolide
    Outcome
    No significant changeSurgical feasibility
    Study

    n: not reported in source

    Comparator
    Controls
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In groups B and C there was a significant reduction in the operating time, bleeding during the operation, and the amount of distention medium required after LA depot administration, but no significant differences in surgical feasibility or efficacy were found in group A patients after treatment.
    2 context sentences
    Summary · context
    Prospective, comparative study.
    Summary · context
    One hundred ninety-three patients (114 pretreated with LA depot and 79 controls) who underwent hysteroscopic surgery for uterine septa (group A), submucous fibroids (group B), and abnormal uterine bleeding (group C).
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with uterine septa, surgical efficacy did not differ significantly after leuprolide versus controls.

    In plain wordsIn patients with uterine septa, surgical efficacy did not differ significantly between leuprolide and controls.

    Peptide
    Leuprolide
    Outcome
    No significant changeSurgical efficacy
    Study

    n: not reported in source

    Comparator
    Controls
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In groups B and C there was a significant reduction in the operating time, bleeding during the operation, and the amount of distention medium required after LA depot administration, but no significant differences in surgical feasibility or efficacy were found in group A patients after treatment.
    2 context sentences
    Summary · context
    Prospective, comparative study.
    Summary · context
    One hundred ninety-three patients (114 pretreated with LA depot and 79 controls) who underwent hysteroscopic surgery for uterine septa (group A), submucous fibroids (group B), and abnormal uterine bleeding (group C).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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