Skip to content

Study · Animal study (in vivo) · cat · 1993

4 results

Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside.

Wang R, Higuera TR, Sikka SC, Minkes RK, Bellan JA, Kadowitz PJ, Domer FR, Hellstrom WJ

Urological research1 Jan 1993Cited by 19 (Europe PMC)

PMID8456543 (opens in a new tab)DOI10.1007/bf00295198 (opens in a new tab)PepBankPUB-08456543
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult cats, intracavernous VIP increased intracavernous pressure in a dose-dependent manner, with a maximal response at 5 micrograms.

    In plain wordsIn cats, VIP injected into the penis raised pressure in the erectile tissue as the dose rose.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseIntracavernous pressure
    Study

    catn = 22

    adult cats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    5 micrograms (maximal response) · intracavernous injectionAs given in this study (cat).

    Source sentences

    Summary
    VIP and SNP increased the intracavernous pressure and caused erection in a dose-dependent manner with a maximal response obtained with 5 micrograms VIP or 10 micrograms SNP
    1 context sentence
    Summary · context
    The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult cats, intracavernous VIP caused erection in a dose-dependent manner, with a maximal response at 5 micrograms.

    In plain wordsIn cats, VIP injected into the penis caused erection, more strongly at higher doses.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreasePenile erection
    Study

    catn = 22

    adult cats
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    5 micrograms (maximal response) · intracavernous injectionAs given in this study (cat).

    Source sentences

    Summary
    VIP and SNP increased the intracavernous pressure and caused erection in a dose-dependent manner with a maximal response obtained with 5 micrograms VIP or 10 micrograms SNP
    1 context sentence
    Summary · context
    The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult cats, the duration of peak erection was significantly shorter with VIP than with the reference combination of papaverine, PGE1 and phentolamine.

    In plain wordsIn cats, peak erection after VIP lasted shorter than after a reference mix of papaverine, PGE1 and phentolamine.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseDuration of peak erection
    Study

    catn = 22

    adult cats
    Comparator
    Reference combination of papaverine, PGE1 and phentolamine
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · intracavernous injectionAs given in this study (cat).

    Source sentences

    Summary
    The duration of peak erection and the total duration of drug effect were significantly shorter with VIP and SNP than with the reference combination (P < 0.01).
    1 context sentence
    Summary · context
    The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In adult cats, the total duration of drug effect was significantly shorter with VIP than with the reference combination of papaverine, PGE1 and phentolamine.

    In plain wordsIn cats, the whole effect of VIP lasted shorter than that of a reference mix of papaverine, PGE1 and phentolamine.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseTotal duration of drug effect
    Study

    catn = 22

    adult cats
    Comparator
    Reference combination of papaverine, PGE1 and phentolamine
    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · intracavernous injectionAs given in this study (cat).

    Source sentences

    Summary
    The duration of peak erection and the total duration of drug effect were significantly shorter with VIP and SNP than with the reference combination (P < 0.01).
    1 context sentence
    Summary · context
    The use of vasoactive intestinal peptide (VIP), sodium nitroprusside (SNP), and the reference combination of papaverine, prostaglandin E1, and phentolamine was studied in 22 adult cats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.