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Study · In vitro (cells) · avian · 1993

6 results

The effect of synthetic thymulin on cell surface marker expression by avian T-cell precursors.

Chang WP, Marsh JA

Developmental and comparative immunology1 Jan 1993Cited by 6 (Europe PMC)

PMID8449254 (opens in a new tab)DOI10.1016/0145-305x(93)90018-l (opens in a new tab)PepBankPUB-08449254
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In avian bone marrow cells, thymulin exposure enhanced PNA binding.

    In plain wordsIn cells from birds, thymulin increased PNA binding.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasePNA binding in bone marrow cells
    Study

    aviann: not reported in source

    Avian bone marrow cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Enhanced PNA binding to both BM cells and thymocytes resulted following an in vitro thymulin exposure but cell proliferation was not affected.
    1 context sentence
    Summary · context
    The effects of the in vitro exposure of avian bone marrow (BM) cells and thymocytes to synthetic thymulin were studied.
  2. 02LabIn vitro (cells)Mechanism

    In avian thymocytes, thymulin exposure enhanced PNA binding.

    In plain wordsIn cells from birds, thymulin increased PNA binding in thymocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasePNA binding in thymocytes
    Study

    aviann: not reported in source

    Avian thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Enhanced PNA binding to both BM cells and thymocytes resulted following an in vitro thymulin exposure but cell proliferation was not affected.
    1 context sentence
    Summary · context
    The effects of the in vitro exposure of avian bone marrow (BM) cells and thymocytes to synthetic thymulin were studied.
  3. 03LabIn vitro (cells)Mechanism

    In avian bone marrow cells and thymocytes, thymulin exposure did not affect cell proliferation.

    In plain wordsIn cells from birds, thymulin did not change cell multiplication.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeCell proliferation
    Study

    aviann: not reported in source

    Avian bone marrow cells and thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Enhanced PNA binding to both BM cells and thymocytes resulted following an in vitro thymulin exposure but cell proliferation was not affected.
    1 context sentence
    Summary · context
    The effects of the in vitro exposure of avian bone marrow (BM) cells and thymocytes to synthetic thymulin were studied.
  4. 04LabIn vitro (cells)Mechanism

    In avian cell assays, thymulin increased PNA binding affinity significantly.

    In plain wordsIn lab tests with bird cells, thymulin increased PNA binding strength.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasePNA binding affinity
    Study

    aviann: not reported in source

    Avian bone marrow cells and thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Scatchard analysis supported the conclusion that PNA binding affinity was significantly increased and thus responsible for the observed increase in PNA binding.
    1 context sentence
    Summary · context
    The effects of the in vitro exposure of avian bone marrow (BM) cells and thymocytes to synthetic thymulin were studied.
  5. 05LabIn vitro (cells)Mechanism

    In avian thymocytes, thymulin-induced PNA-positive cells may differ from cells with enhanced CT-1a expression.

    In plain wordsIn cells from birds, thymulin-induced PNA-positive thymocytes may differ from thymocytes with increased CT-1a expression.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Not applicableThymocyte differentiation populations
    Study

    aviann: not reported in source

    Avian thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometric analysis suggested that the induced PNA+ thymocyte population may be a different population from the one exhibiting enhanced CT-1a expression following thymulin exposure.
    1 context sentence
    Summary · context
    The effects of the in vitro exposure of avian bone marrow (BM) cells and thymocytes to synthetic thymulin were studied.
  6. 06LabIn vitro (cells)Mechanism

    In avian thymocytes, CT-1a expression increased following thymulin exposure.

    In plain wordsIn cells from birds, thymulin exposure increased CT-1a expression in thymocytes.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCT-1a expression
    Study

    aviann: not reported in source

    Avian thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometric analysis suggested that the induced PNA+ thymocyte population may be a different population from the one exhibiting enhanced CT-1a expression following thymulin exposure.
    1 context sentence
    Summary · context
    The effects of the in vitro exposure of avian bone marrow (BM) cells and thymocytes to synthetic thymulin were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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