Effect of growth hormone (GH)-releasing hormone (GHRH), atropine, pyridostigmine, or hypoglycemia on GHRP-6-induced GH secretion in man.

Peñalva A, Carballo A, Pombo M, Casanueva FF, Dieguez C

The Journal of clinical endocrinology and metabolism1 Jan 1993Cited by 41 (Europe PMC)

PMID8421084DOI10.1210/jcem.76.1.8421084PepBankPUB-08421084

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. 3 results from people.

01HumanNon-randomized trialMechanism
In normal men, GHRP‑6 and GHRH produced similar increases in plasma GH.
In plain wordsIn men, GHRP‑6 and GHRH produced similar increases in growth hormone levels.
Peptide
GHRP-6
Outcome
No significant changeGH response versus GHRH
Study
n: not reported in source
Comparator
GHRH
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microgram/kgAs given in this study (human).
Measurements
GH AUC
973 not stated
GHRP-6
GH AUC
821 not stated
GHRH (comparator)
Source sentences
Summary
We found a similar increase in plasma GH levels after the administration of either GHRP-6 (1 microgram/kg) or GHRH (1 microgram/kg); the areas under the curve (AUC) were (mean +/- SEM) 973 +/- 181 and 821 +/- 139, respectively.
Report a problemFND-0842108401
02HumanNon-randomized trialMechanism
In normal men, combined GHRP‑6 and GHRH produced greater GH responses than GHRH alone.
In plain wordsIn men, adding GHRP‑6 to GHRH increased growth hormone responses compared with GHRH alone.
Peptide
GHRP-6
Outcome
IncreaseCombined GH response versus GHRH
Study
n: not reported in source
Comparator
GHRH alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Measurements
GH AUC
4412 not stated
Combined GHRP-6 and GHRH
GH AUC
821 not stated
GHRH alone
Source sentences
Summary
After combined GHRP-6 and GHRH administration, GH responses were considerably greater than those after either compound alone (4412 +/- 842; P < 0.01).
Summary
the areas under the curve (AUC) were (mean +/- SEM) 973 +/- 181 and 821 +/- 139, respectively
Report a problemFND-0842108402
03HumanNon-randomized trialMechanism
In normal men, combined GHRP‑6 and insulin increased GH more than insulin alone.
In plain wordsIn men, adding GHRP‑6 to insulin increased growth hormone more than insulin alone.
Peptide
GHRP-6
Outcome
IncreaseCombined GH response versus insulin
Study
n: not reported in source
Comparator
Insulin alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Measurements
GH AUC
4047 not stated
Combined GHRP-6 and insulin
GH AUC
1747 not stated
Insulin alone
Source sentences
Summary
Finally, combined GHRP-6 and insulin administration induced a much greater increase in plasma GH levels (AUC, 4047 +/- 327) than insulin alone (1747 +/- 229; P < 0.05) or GHRP-6 alone (1248 +/- 376; P < 0.05).
Report a problemFND-0842108406

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

04HumanNot a test of GHRP-6 aloneNon-randomized trialMechanism
In normal men, combined GHRP‑6 and GHRH produced greater GH responses than GHRP‑6 alone.
In plain wordsIn men, combined GHRP‑6 and GHRH increased growth hormone responses compared with GHRP‑6 alone.
Peptide
GHRP-6
Outcome
IncreaseCombined GH response versus GHRP-6
Study
n: not reported in source
Comparator
GHRP-6 alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
4412 not stated
Combined GHRP-6 and GHRH
GH AUC
973 not stated
GHRP-6 alone
Source sentences
Summary
After combined GHRP-6 and GHRH administration, GH responses were considerably greater than those after either compound alone (4412 +/- 842; P < 0.01).
Summary
the areas under the curve (AUC) were (mean +/- SEM) 973 +/- 181 and 821 +/- 139, respectively
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0842108403
05HumanNot a test of GHRP-6 aloneNon-randomized trialMechanism
In normal men, atropine completely prevented GH responses to GHRP‑6.
In plain wordsIn men, atropine blocked the growth hormone response to GHRP‑6.
Peptide
GHRP-6
Outcome
DecreaseAtropine-modified GH response
Study
n: not reported in source
Comparator
GHRP-6 alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
103 not stated
GHRP-6 after atropine
GH AUC
815 not stated
GHRP-6 alone
Source sentences
Summary
Administration of the cholinergic receptor antagonist atropine (1 mg, im) completely prevented the GH responses to GHRP-6 (area under the curve, 103 +/- 14 vs. 815 +/- 156, respectively).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0842108404
06HumanNot a test of GHRP-6 aloneNon-randomized trialMechanism
In normal men, pyridostigmine slightly increased GH responses to GHRP‑6 versus GHRP‑6 alone.
In plain wordsIn men, pyridostigmine increased growth hormone responses to GHRP‑6 compared with GHRP‑6 alone.
Peptide
GHRP-6
Outcome
IncreasePyridostigmine-modified GH response
Study
n: not reported in source
Comparator
GHRP-6 alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
1571 not stated
GHRP-6 after pyridostigmine
GH AUC
815 not stated
GHRP-6 alone
Source sentences
Summary
On the other hand, pyridostigmine, a cholinergic agonist, slightly increased GH responses to GHRP-6 (P < 0.01 when comparing the AUC after pyridostigmine administration of 1571 +/- 151 and the AUC after administration of GHRP-6 alone of 815 +/- 156).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0842108405
07HumanNot a test of GHRP-6 aloneNon-randomized trialMechanism
In normal men, combined GHRP‑6 and insulin increased GH more than GHRP‑6 alone.
In plain wordsIn men, combined GHRP‑6 and insulin increased growth hormone more than GHRP‑6 alone.
Peptide
GHRP-6
Outcome
IncreaseCombined GH response versus GHRP-6
Study
n: not reported in source
Comparator
GHRP-6 alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH AUC
4047 not stated
combined GHRP-6 and insulin
GH AUC
1248 not stated
GHRP-6 alone
Source sentences
Summary
Finally, combined GHRP-6 and insulin administration induced a much greater increase in plasma GH levels (AUC, 4047 +/- 327) than insulin alone (1747 +/- 229; P < 0.05) or GHRP-6 alone (1248 +/- 376; P < 0.05).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0842108407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:59 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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