In Vietnam veterans with PTSD, physiologic responding during combat imagery followed the order vasopressin > placebo > oxytocin, so it was lowest after intranasal oxytocin 20 IU.
In plain wordsIn veterans with PTSD, body stress responses to combat imagery were lowest after oxytocin, below placebo; the abstract reports only the group order.
- Peptide
- Oxytocin
- Outcome
- DecreasePhysiologic responding (heart rate, skin conductance, EMG) during combat imagery
- Study
n = 43
- Comparator
- Placebo
- Outcome group
- Anxiety and mood · Mental health and mood
- Studied dose
- 20 IU · intranasalAs given in this study (human).
Source sentences
The group order of physiologic responding was as predicted: vasopressin > placebo > oxytocin.
2 context sentences(design, population, supporting numbers)
This study measured heart rate, skin conductance, and lateral frontalis electromyographic (EMG) responses in 43 male Vietnam veterans with posttraumatic stress disorder during personal combat imagery.
In a double-blind research design, subjects were randomly assigned to receive intranasal arginine vasopressin (20 IU), placebo, or oxytocin (20 IU) an hour before the experiment.