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Study · Ex vivo tissue · rat · 1993

2 results

High affinity amylin binding sites in rat brain.

Beaumont K, Kenney MA, Young AA, Rink TJ

Molecular pharmacology1 Sept 1993Cited by 137 (Europe PMC)

PMID8396712 (opens in a new tab)DOI10.1016/s0026-895x(25)13212-4 (opens in a new tab)PepBankPUB-08396712
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat nucleus accumbens membranes, salmon calcitonin had high affinity for amylin binding sites, unlike rat calcitonin.

    In plain wordsIn lab tests with rat brain membranes, salmon calcitonin bound amylin sites strongly compared with rat calcitonin.

    Peptide
    Calcitonin-salmon
    Outcome
    IncreaseAffinity for amylin binding sites
    Study

    ratn: not reported in source

    Rat nucleus accumbens membranes
    Comparator
    Rat calcitonin
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast to rat calcitonin, salmon calcitonin has a high affinity for these sites, indicating that it shares critical binding determinants with amylin.
    1 context sentence
    Summary · context
    Competition experiments show that sites measured in nucleus accumbens membranes have high affinity for rat amylin, lower affinity for rat calcitonin gene-related peptides, and very low affinity for rat calcitonin.
  2. 02LabEx vivo tissueActivity measurement

    In rat soleus muscle, salmon calcitonin potently inhibited insulin-stimulated glucose incorporation into glycogen.

    In plain wordsIn lab tests with rat muscle, salmon calcitonin reduced insulin-stimulated sugar incorporation into glycogen compared with insulin stimulation alone.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseInsulin-stimulated glycogen synthesis
    Study

    ratn: not reported in source

    Rat soleus muscle
    Comparator
    Insulin stimulation
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Salmon calcitonin potently inhibits insulin-stimulated glucose incorporation into rat soleus muscle glycogen,

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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