Degradation of ACTH/MSH(4-10) and its synthetic analog semax by rat serum enzymes: an inhibitor study.

Potaman VN, Alfeeva LY, Kamensky AA, Nezavibatko VN

Peptides1 May 1993Cited by 14 (Europe PMC)

PMID8392718DOI10.1016/0196-9781(93)90137-6PepBankPUB-08392718

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

01LabNot a test of Semax aloneEx vivo tissueOther
In rat serum, bestatin inhibited up to 66% of total degrading activity against semax and ACTH/MSH(4-10).
In plain wordsIn lab tests with rat serum, an aminopeptidase inhibitor blocked up to 66% of the activity that breaks down semax.
Peptide
Semax
Outcome
DecreaseInhibition of semax degradation by bestatin
Study
ratn: not reported in source
Rat serum
Comparator
No inhibitor
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Inhibition of degrading activity
≤ 66%
bestatin
Source sentences
Summary
Bestatin inhibited up to 66%, puromycin about 33%, and lisinopril about 15% of total degrading activity against both ACTH/MSH(4-10) and semax.
1 context sentence(design, population, supporting numbers)
Summary · context
Degradation of the behaviorally active peptide ACTH/MSH(4-10) and its synthetic analog semax was studied in serum in the presence of several specific peptidase inhibitors.
In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.
Report a problemFND-0839271801
02LabNot a test of Semax aloneEx vivo tissueOther
In rat serum, puromycin inhibited about 33% of total degrading activity against semax and ACTH/MSH(4-10).
In plain wordsIn lab tests with rat serum, puromycin blocked about 33% of the activity that breaks down semax.
Peptide
Semax
Outcome
DecreaseInhibition of semax degradation by puromycin
Study
ratn: not reported in source
Rat serum
Comparator
No inhibitor
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Inhibition of degrading activity
≈ 33%
puromycin
Source sentences
Summary
Bestatin inhibited up to 66%, puromycin about 33%, and lisinopril about 15% of total degrading activity against both ACTH/MSH(4-10) and semax.
1 context sentence(design, population, supporting numbers)
Summary · context
Degradation of the behaviorally active peptide ACTH/MSH(4-10) and its synthetic analog semax was studied in serum in the presence of several specific peptidase inhibitors.
In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.
Report a problemFND-0839271802
03LabNot a test of Semax aloneEx vivo tissueOther
In rat serum, lisinopril inhibited about 15% of total degrading activity against semax and ACTH/MSH(4-10).
In plain wordsIn lab tests with rat serum, lisinopril blocked about 15% of the activity that breaks down semax.
Peptide
Semax
Outcome
DecreaseInhibition of semax degradation by lisinopril
Study
ratn: not reported in source
Rat serum
Comparator
No inhibitor
Outcome group
Pharmacokinetics · Pharmacology
Measurements
Inhibition of degrading activity
≈ 15%
lisinopril
Source sentences
Summary
Bestatin inhibited up to 66%, puromycin about 33%, and lisinopril about 15% of total degrading activity against both ACTH/MSH(4-10) and semax.
1 context sentence(design, population, supporting numbers)
Summary · context
Degradation of the behaviorally active peptide ACTH/MSH(4-10) and its synthetic analog semax was studied in serum in the presence of several specific peptidase inhibitors.
In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.
Report a problemFND-0839271803
04LabNot a test of Semax aloneEx vivo tissueOther
In rat serum, the involvement of neutral endopeptidase and prolyl endopeptidase in hydrolysis of semax and ACTH/MSH(4-10) was less definitive.
In plain wordsIn lab tests with rat serum, two other enzymes had a less clear role in breaking down semax.
Peptide
Semax
Outcome
Not applicableRole of neutral endopeptidase and prolyl endopeptidase in hydrolysis
Study
ratn: not reported in source
Rat serum
Comparator
No inhibitor
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Involvement of neutral endopeptidase and prolyl endopeptidase in hydrolysis of the two peptides was less definitive.
1 context sentence(design, population, supporting numbers)
Summary · context
Degradation of the behaviorally active peptide ACTH/MSH(4-10) and its synthetic analog semax was studied in serum in the presence of several specific peptidase inhibitors.
In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.
Report a problemFND-0839271804

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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