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Study · Non-randomized trial · n = 133 · 1993

5 results

Gonadotropin releasing hormone agonist treatment before hysterectomy for menorrhagia and uterine leiomyomas.

Vercellini P, Bocciolone L, Colombo A, Vendola N, Meschia M, Bolis G

Acta obstetricia et gynecologica Scandinavica1 Jul 1993Cited by 19 (Europe PMC)

PMID8392268 (opens in a new tab)DOI10.3109/00016349309021115 (opens in a new tab)PepBankPUB-08392268
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In anemic women with fibroids, abdominal hysterectomy was indicated in 54% after goserelin versus 80% of controls.

    In plain wordsIn anemic women with fibroids, abdominal hysterectomy was indicated in 54% after goserelin versus 80% of controls.

    Peptide
    Goserelin
    Outcome
    DecreaseAbdominal hysterectomy indication
    Study

    n = 133

    Comparator
    Immediate surgery
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Measurements

    Abdominal hysterectomy indication
    22 cases
    goserelin
    Abdominal hysterectomy indication
    54%
    goserelin
    Abdominal hysterectomy indication
    74 cases
    controls
    Abdominal hysterectomy indication
    80%
    controls

    Source sentences

    Summary
    At preoperative pelvic exploration abdominal hysterectomy was indicated in 22 (54%) cases and 74 (80%) controls and vaginal hysterectomy in 19 (46%) and 18 (20%) (relative risk 3.6, 95% confidence interval 1.6 to 7.7; p = 0.001).
    3 context sentences
    Summary · context
    Prospective, comparative, nonrandomized study.
    Summary · context
    Anemic women requiring hysterectomy for myoma-associated menorrhagia.
    Summary · context
    Six months' preoperative goserelin treatment (41 cases) or immediate surgery (92 controls).
  2. 02HumanNon-randomized trialEfficacy outcome

    In anemic women with fibroids, vaginal hysterectomy was indicated in 46% after goserelin versus 20% of controls.

    In plain wordsIn anemic women with fibroids, vaginal hysterectomy was indicated in 46% after goserelin versus 20% of controls.

    Peptide
    Goserelin
    Outcome
    IncreaseVaginal hysterectomy indication
    Study

    n = 133

    Comparator
    Immediate surgery
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Measurements

    Vaginal hysterectomy indication
    19 cases
    goserelin
    Vaginal hysterectomy indication
    46%
    goserelin
    Vaginal hysterectomy indication
    18 cases
    controls
    Vaginal hysterectomy indication
    20%
    controls
    Relative risk
    3.6
    95% CI 1.6 to 7.7; p = 0.001

    Source sentences

    Summary
    At preoperative pelvic exploration abdominal hysterectomy was indicated in 22 (54%) cases and 74 (80%) controls and vaginal hysterectomy in 19 (46%) and 18 (20%) (relative risk 3.6, 95% confidence interval 1.6 to 7.7; p = 0.001).
    3 context sentences
    Summary · context
    Prospective, comparative, nonrandomized study.
    Summary · context
    Anemic women requiring hysterectomy for myoma-associated menorrhagia.
    Summary · context
    Six months' preoperative goserelin treatment (41 cases) or immediate surgery (92 controls).
  3. 03HumanNon-randomized trialEfficacy outcome

    In anemic women with fibroids, no goserelin-treated case required transfusion, whereas 51% of controls did.

    In plain wordsIn anemic women with fibroids, no goserelin-treated patient needed transfusion, compared with 51% of controls.

    Peptide
    Goserelin
    Outcome
    DecreaseTransfusion requirement
    Study

    n = 133

    Comparator
    Immediate surgery
    Outcome group
    Surgical outcomes · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Measurements

    Controls requiring transfusion
    51%
    immediate surgery
    Packed red cell units
    127 units
    controls

    Source sentences

    Summary
    No case required a transfusion whereas 51% of controls needed a total of 127 packed red cell units.
    3 context sentences
    Summary · context
    Prospective, comparative, nonrandomized study.
    Summary · context
    Anemic women requiring hysterectomy for myoma-associated menorrhagia.
    Summary · context
    Six months' preoperative goserelin treatment (41 cases) or immediate surgery (92 controls).
  4. 04HumanNon-randomized trialEfficacy outcome

    In anemic women with myoma-associated menorrhagia, mean hemoglobin rose from 8.5 to 13.3 g/dl with goserelin.

    In plain wordsIn anemic women with fibroids, mean hemoglobin rose from 8.5 to 13.3 g/dl with goserelin.

    Peptide
    Goserelin
    Outcome
    IncreaseHemoglobin
    Study

    n = 41

    Outcome group
    Overall treatment effect · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Measurements

    Hemoglobin
    8.5 g/dl
    baseline
    Hemoglobin
    13.3 g/dl
    after goserelin

    Source sentences

    Summary
    In the goserelin group mean hemoglobin rose (8.5 versus 13.3 g/dl) and mean uterine volume decreased (528 versus 251 ml).
    3 context sentences
    Summary · context
    Prospective, comparative, nonrandomized study.
    Summary · context
    Anemic women requiring hysterectomy for myoma-associated menorrhagia.
    Summary · context
    Six months' preoperative goserelin treatment (41 cases) or immediate surgery (92 controls).
  5. 05HumanNon-randomized trialEfficacy outcome

    In women with myoma-associated menorrhagia, mean uterine volume decreased from 528 to 251 ml with goserelin.

    In plain wordsIn women with fibroids, mean uterine volume fell from 528 to 251 ml with goserelin.

    Peptide
    Goserelin
    Outcome
    DecreaseUterine volume
    Study

    n = 41

    Outcome group
    Uterine Volume · Reproductive and sexual health
    Studied dose
    Dose not stated · 6 monthsAs given in this study (human).

    Measurements

    Uterine volume
    528 ml
    baseline
    Uterine volume
    251 ml
    after goserelin

    Source sentences

    Summary
    In the goserelin group mean hemoglobin rose (8.5 versus 13.3 g/dl) and mean uterine volume decreased (528 versus 251 ml).
    3 context sentences
    Summary · context
    Prospective, comparative, nonrandomized study.
    Summary · context
    Anemic women requiring hysterectomy for myoma-associated menorrhagia.
    Summary · context
    Six months' preoperative goserelin treatment (41 cases) or immediate surgery (92 controls).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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