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Study · Animal study (in vivo) · rat · 1993

6 results

Octreotide effectively decreases mucosal damage in experimental colitis.

Eliakim R, Karmeli F, Okon E, Rachmilewitz D

Gut1 Feb 1993Cited by 50 (Europe PMC)

PMID8381760 (opens in a new tab)PMCIDPMC1373982 (opens in a new tab)DOI10.1136/gut.34.2.264 (opens in a new tab)PepBankPUB-08381760
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental colitis, octreotide significantly reduced mucosal damage.

    In plain wordsIn rats with experimental colitis, octreotide reduced mucosal damage compared with acetic acid injury.

    Peptide
    Octreotide
    Outcome
    DecreaseMucosal damage
    Study

    ratn: not reported in source

    Acetic acid-induced colitis
    Comparator
    Acetic acid-induced colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    10 micrograms/rat · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Subcutaneous administration of octreotide (10 micrograms/rat) 1 hour before or immediately after damage induction, as well as 1 and 23 hours after acetic acid application, resulted in a significant reduction in mucosal damage.
    2 context sentences
    Summary · context
    The effect of octreotide, a synthetic analogue of somatostatin, on the modulation of the acetic acid model of experimental colitis was examined.
    Summary · context
    Colitis was induced by intracolonic administration of 2 ml of 5% acetic acid.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental colitis, octreotide significantly reduced platelet activating factor activity.

    In plain wordsIn rats with experimental colitis, octreotide reduced platelet activating factor activity compared with acetic acid injury.

    Peptide
    Octreotide
    Outcome
    DecreasePlatelet activating factor activity
    Study

    ratn: not reported in source

    Acetic acid-induced colitis
    Comparator
    Acetic acid-induced colitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    10 micrograms/rat · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The protective effect was accompanied by a significant reduction in platelet activating factor activity, leukotriene B4, and vasoactive intestinal peptide concentrations.
    3 context sentences
    Summary · context
    The effect of octreotide, a synthetic analogue of somatostatin, on the modulation of the acetic acid model of experimental colitis was examined.
    Summary · context
    Colitis was induced by intracolonic administration of 2 ml of 5% acetic acid.
    Summary · context
    Subcutaneous administration of octreotide (10 micrograms/rat) 1 hour before or immediately after damage induction, as well as 1 and 23 hours after acetic acid application, resulted in a significant reduction in mucosal damage.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental colitis, octreotide significantly reduced leukotriene B4.

    In plain wordsIn rats with experimental colitis, octreotide reduced leukotriene B4 compared with acetic acid injury.

    Peptide
    Octreotide
    Outcome
    DecreaseLeukotriene B4
    Study

    ratn: not reported in source

    Acetic acid-induced colitis
    Comparator
    Acetic acid-induced colitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    10 micrograms/rat · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The protective effect was accompanied by a significant reduction in platelet activating factor activity, leukotriene B4, and vasoactive intestinal peptide concentrations.
    3 context sentences
    Summary · context
    The effect of octreotide, a synthetic analogue of somatostatin, on the modulation of the acetic acid model of experimental colitis was examined.
    Summary · context
    Colitis was induced by intracolonic administration of 2 ml of 5% acetic acid.
    Summary · context
    Subcutaneous administration of octreotide (10 micrograms/rat) 1 hour before or immediately after damage induction, as well as 1 and 23 hours after acetic acid application, resulted in a significant reduction in mucosal damage.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental colitis, octreotide significantly reduced vasoactive intestinal peptide concentrations.

    In plain wordsIn rats with experimental colitis, octreotide reduced vasoactive intestinal peptide concentrations compared with acetic acid injury.

    Peptide
    Octreotide
    Outcome
    DecreaseVasoactive intestinal peptide concentrations
    Study

    ratn: not reported in source

    Acetic acid-induced colitis
    Comparator
    Acetic acid-induced colitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    10 micrograms/rat · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The protective effect was accompanied by a significant reduction in platelet activating factor activity, leukotriene B4, and vasoactive intestinal peptide concentrations.
    3 context sentences
    Summary · context
    The effect of octreotide, a synthetic analogue of somatostatin, on the modulation of the acetic acid model of experimental colitis was examined.
    Summary · context
    Colitis was induced by intracolonic administration of 2 ml of 5% acetic acid.
    Summary · context
    Subcutaneous administration of octreotide (10 micrograms/rat) 1 hour before or immediately after damage induction, as well as 1 and 23 hours after acetic acid application, resulted in a significant reduction in mucosal damage.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental colitis, octreotide did not significantly change mucosal leukotriene C4 levels.

    In plain wordsIn rats with experimental colitis, octreotide did not significantly change mucosal leukotriene C4 compared with acetic acid injury.

    Peptide
    Octreotide
    Outcome
    No significant changeMucosal leukotriene C4
    Study

    ratn: not reported in source

    Acetic acid-induced colitis
    Comparator
    Acetic acid-induced colitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    10 micrograms/rat · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    There were no significant changes in mucosal leukotriene C4 and calcitonin gene related peptide levels.
    3 context sentences
    Summary · context
    The effect of octreotide, a synthetic analogue of somatostatin, on the modulation of the acetic acid model of experimental colitis was examined.
    Summary · context
    Colitis was induced by intracolonic administration of 2 ml of 5% acetic acid.
    Summary · context
    Subcutaneous administration of octreotide (10 micrograms/rat) 1 hour before or immediately after damage induction, as well as 1 and 23 hours after acetic acid application, resulted in a significant reduction in mucosal damage.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with experimental colitis, octreotide did not significantly change mucosal calcitonin gene related peptide levels.

    In plain wordsIn rats with experimental colitis, octreotide did not significantly change mucosal calcitonin gene related peptide compared with acetic acid injury.

    Peptide
    Octreotide
    Outcome
    No significant changeMucosal calcitonin gene related peptide
    Study

    ratn: not reported in source

    Acetic acid-induced colitis
    Comparator
    Acetic acid-induced colitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    10 micrograms/rat · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    There were no significant changes in mucosal leukotriene C4 and calcitonin gene related peptide levels.
    3 context sentences
    Summary · context
    The effect of octreotide, a synthetic analogue of somatostatin, on the modulation of the acetic acid model of experimental colitis was examined.
    Summary · context
    Colitis was induced by intracolonic administration of 2 ml of 5% acetic acid.
    Summary · context
    Subcutaneous administration of octreotide (10 micrograms/rat) 1 hour before or immediately after damage induction, as well as 1 and 23 hours after acetic acid application, resulted in a significant reduction in mucosal damage.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

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