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Study · Non-randomized trial · n = 11 · 1993

2 results

The growth hormone (GH) response to GH-releasing peptide (His-DTrp-Ala-Trp-DPhe-Lys-NH2), GH-releasing hormone, and thyrotropin-releasing hormone in acromegaly.

Alster DK, Bowers CY, Jaffe CA, Ho PJ, Barkan AL

The Journal of clinical endocrinology and metabolism1 Sept 1993Cited by 14 (Europe PMC)

PMID8370708 (opens in a new tab)DOI10.1210/jcem.77.3.8370708 (opens in a new tab)PepBankPUB-08370708
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialMechanism

    In patients with active acromegaly, peak GH responses to GHRP and GHRH were not significantly correlated.

    In plain wordsIn patients with acromegaly, growth hormone responses to GHRP and GHRH were not significantly linked.

    Peptide
    GHRP-6
    Outcome
    Not applicableCorrelation with GHRH response
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Correlation coefficient
    0.57 r
    GHRP versus GHRH

    Source sentences

    Summary
    The peak GH responses to GHRP and GHRH were not correlated (r = 0.57; P = 0.066).
    1 context sentence
    Summary · context
    We studied the GH responses to GHRH, GHRP, and TRH stimulation in 11 patients with active acromegaly.
  2. 02HumanNon-randomized trialMechanism

    In patients with active acromegaly, peak GH responses to GHRP and TRH were highly correlated.

    In plain wordsIn patients with acromegaly, growth hormone responses to GHRP and TRH were strongly linked.

    Peptide
    GHRP-6
    Outcome
    Not applicableCorrelation with TRH response
    Study

    n = 11

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Correlation coefficient
    0.95 r
    GHRP versus TRH

    Source sentences

    Summary
    In contrast, the peak GH responses to GHRP and TRH were highly correlated (r = 0.95; P < 0.001).
    1 context sentence
    Summary · context
    We studied the GH responses to GHRH, GHRP, and TRH stimulation in 11 patients with active acromegaly.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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