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Study · Not a test of the peptide alone · 1993

3 results

Effect of oestradiol on oxytocin-stimulated prostaglandin F2 alpha release in mares.

Goff AK, Sirois J, Pontbriand D

Journal of reproduction and fertility1 May 1993Cited by 12 (Europe PMC)

PMID8345453 (opens in a new tab)DOI10.1530/jrf.0.0980107 (opens in a new tab)PepBankPUB-08345453
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In cyclic mares challenged with oxytocin, intrauterine oestradiol from Silastic spheres enhanced the oxytocin-stimulated PGFM concentrations compared with controls; oxytocin was only the challenge.

    In plain wordsIn mares, a small uterine dose of oestradiol made the PGFM rise after an oxytocin challenge larger than in controls.

    Peptide
    Oxytocin
    Outcome
    IncreasePGFM response to oxytocin challenge after intrauterine oestradiol
    Study

    horse (mare)n = 10

    cyclic mares
    Comparator
    Silastic spheres without oestradiol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    The results showed that oestradiol enhanced (four times greater than controls at day 13; P < 0.05) the oxytocin stimulation of PGFM concentrations.(ABSTRACT TRUNCATED AT 250 WORDS)
    2 context sentences
    Summary · context
    Small Silastic spheres (1 cm diameter) were impregnated with or without oestradiol at a concentration that gave a release rate similar to that of embryos at day 12 (10 ng h-1).
    Summary · context
    These were inserted (one per mare) into the uterus of two groups of mares (five per group) on day 7.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In cyclic mares challenged with intravenous oxytocin, systemic oestradiol greatly increased the oxytocin-stimulated PGFM response compared with vehicle; oxytocin was only the challenge.

    In plain wordsIn mares, oestradiol made the PGFM rise after an oxytocin challenge much larger than in controls.

    Peptide
    Oxytocin
    Outcome
    IncreasePGFM response to oxytocin challenge after systemic oestradiol
    Study

    horse (mare)n = 8

    cyclic mares
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Results showed a significant stimulatory effect of oestradiol (five times greater than controls at day 11; P < 0.05), but not of 17 alpha-oestradiol, on the oxytocin stimulation of PGFM.
    2 context sentences
    Summary · context
    In the first experiment, three groups of mares (4 per group) were given a bolus injection of 17 alpha-oestradiol (1 mg), oestradiol (1 mg) or vehicle on days 7, 9, 11, 13 and 15 of the cycle.
    Summary · context
    Six hours later the mares were challenged with 10 iu oxytocin intravenously and frequent blood samples were taken from 15 min before to 15 min after for measurement of PGFM.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In cyclic mares challenged with intravenous oxytocin, 17 alpha-oestradiol did not increase the oxytocin-stimulated PGFM response; oxytocin was only the challenge.

    In plain wordsIn mares, 17 alpha-oestradiol did not change the PGFM rise after an oxytocin challenge.

    Peptide
    Oxytocin
    Outcome
    No significant changePGFM response to oxytocin challenge after 17 alpha-oestradiol
    Study

    horse (mare)n = 8

    cyclic mares
    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Results showed a significant stimulatory effect of oestradiol (five times greater than controls at day 11; P < 0.05), but not of 17 alpha-oestradiol, on the oxytocin stimulation of PGFM.
    2 context sentences
    Summary · context
    In the first experiment, three groups of mares (4 per group) were given a bolus injection of 17 alpha-oestradiol (1 mg), oestradiol (1 mg) or vehicle on days 7, 9, 11, 13 and 15 of the cycle.
    Summary · context
    Six hours later the mares were challenged with 10 iu oxytocin intravenously and frequent blood samples were taken from 15 min before to 15 min after for measurement of PGFM.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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