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Study · Animal study (in vivo) · gerbil · 1993

3 results

[Protective effect of FPF 1070 (cerebrolysin) on delayed neuronal death in the gerbil--detection of hydroxyl radicals with salicylic acid].

Sugita Y, Kondo T, Kanazawa A, Itou T, Mizuno Y

No to shinkei = Brain and nerve1 Apr 1993Cited by 16 (Europe PMC)

PMID8334017 (opens in a new tab)PepBankPUB-08334017
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In gerbils, FPF 1070 significantly protected CA1 neurons when given before carotid occlusion.

    In plain wordsIn gerbils, cerebrolysin protected CA1 neurons when given before ischemia.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCA1 neuronal protection before ischemia
    Study

    gerbiln: not reported in source

    Transient forebrain ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Gerbils treated with FPF 1070 revealed significant protection of CA1 neurons when it was applied 2 hrs before the occlusion.
    2 context sentences
    Summary · context
    We studied FPF 1070 to determine its ability to protect against delayed neuronal death in the gerbil when administered before and after ischemia.
    Summary · context
    Transient forebrain ischemia was produced by occluding both common carotid arteries.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In gerbils, FPF 1070 showed no clear beneficial effect when given immediately after recirculation.

    In plain wordsIn gerbils, cerebrolysin showed no clear benefit when given immediately after blood flow returned.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeNeuronal protection after recirculation
    Study

    gerbiln: not reported in source

    Transient forebrain ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, no clear beneficial effects were observed when FPF 1070 was administered immediately after the recirculation.
    2 context sentences
    Summary · context
    We studied FPF 1070 to determine its ability to protect against delayed neuronal death in the gerbil when administered before and after ischemia.
    Summary · context
    Transient forebrain ischemia was produced by occluding both common carotid arteries.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In gerbils, FPF 1070 given before occlusion significantly reduced postischemic reperfused brain 2,5-DHBA content.

    In plain wordsIn gerbils, cerebrolysin given before ischemia reduced a marker of hydroxyl radicals in the reperfused brain.

    Peptide
    Cerebrolysin
    Outcome
    DecreasePostischemic brain 2,5-DHBA content
    Study

    gerbiln: not reported in source

    Transient forebrain ischemia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The 2,5-DHBA contents in the postischemic reperfused brain was significantly reduced when FPF 1070 was administered 2 hr. before the occlusion.
    2 context sentences
    Summary · context
    We studied FPF 1070 to determine its ability to protect against delayed neuronal death in the gerbil when administered before and after ischemia.
    Summary · context
    Transient forebrain ischemia was produced by occluding both common carotid arteries.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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