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Study · Not a test of the peptide alone · 1994

3 results

Delta-sleep-inducing peptide: solution conformational studies of a membrane-permeable peptide.

Gray RA, Vander Velde DG, Burke CJ, Manning MC, Middaugh CR, Borchardt RT

Biochemistry1 Feb 1994Cited by 37 (Europe PMC)

PMID8312250 (opens in a new tab)DOI10.1021/bi00172a006 (opens in a new tab)PepBankPUB-08312250
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 01LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Mechanism

    Spectroscopic data suggest that DSIP exists in solution in a dynamic equilibrium between unordered and folded structures.

    In plain wordsIn lab tests, DSIP in solution switches between loose and folded shapes.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSolution conformation equilibrium
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    Our spectroscopic findings suggest that DSIP exists in a dynamic equilibrium between unordered and folded structures.
    1 context sentence
    Summary · context
    This nonapeptide was studied in solution using one- and two-dimensional nuclear magnetic resonance (NMR), circular dichroism (CD), Fourier transform infrared (FT-IR), and fluorescence spectroscopies in conjunction with molecular modeling.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  2. 02LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Mechanism

    In aqueous solution, residues 2-5 and 6-9 of DSIP tend to form type I beta-turns, and a more ordered helix-like structure can be induced in 40% trifluoroethanol.

    In plain wordsIn lab tests, parts of DSIP tend to form turns in water, and a more ordered helix-like shape forms in a solvent mixture.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableSecondary structure of residues 2-5 and 6-9
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Source sentences

    Summary
    Residues 2-5 and 6-9 tend to form type I beta-turns in aqueous solution and a similar, but more ordered, helix-like structure inducible in 40% trifluoroethanol (TFE).
    1 context sentence
    Summary · context
    This nonapeptide was studied in solution using one- and two-dimensional nuclear magnetic resonance (NMR), circular dichroism (CD), Fourier transform infrared (FT-IR), and fluorescence spectroscopies in conjunction with molecular modeling.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

  3. 03LabNot a test of Delta sleep-inducing peptide (DSIP) aloneIn vitro (cell-free)Mechanism

    Infrared data suggest that the beta-turn population of DSIP in aqueous solution is about 40%.

    In plain wordsIn lab tests, infrared data suggest that about 40% of DSIP in water is in a turn shape.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableBeta-turn population by IR
    Study

    n: not reported in source

    Outcome group
    Peptide structure and chemistry · Pharmacology

    Measurements

    beta-turn population
    ≈ 40%
    aqueous solution

    Source sentences

    Summary
    NMR, FT-IR, and CD studies in aqueous solution support the dynamic equilibrium hypothesis with the IR data, suggesting that the beta-turn population is approximately 40%
    1 context sentence
    Summary · context
    This nonapeptide was studied in solution using one- and two-dimensional nuclear magnetic resonance (NMR), circular dichroism (CD), Fourier transform infrared (FT-IR), and fluorescence spectroscopies in conjunction with molecular modeling.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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