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Study · In vitro (cells) · pig · 1993

5 results

Different steroidogenic response of young and aged porcine small and large luteal cells to prostaglandin F2 alpha, oxytocin and estradiol.

Pitzel L, Jarry H, Wuttke W

Experimental and clinical endocrinology1 Jan 1993Cited by 8 (Europe PMC)

PMID8307115 (opens in a new tab)DOI10.1055/s-0029-1211241 (opens in a new tab)PepBankPUB-08307115
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In small and large luteal cells from young porcine corpora lutea, oxytocin inhibited progesterone production.

    In plain wordsIn pig luteal cells from young corpora lutea, oxytocin lowered progesterone production.

    Peptide
    Oxytocin
    Outcome
    DecreaseProgesterone production in young luteal cells
    Study

    pign: not reported in source

    porcine small and large luteal cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In SLC as well as LLC from young CL OXT and PGF2 alpha inhibited progesterone (P) production but induced a strong increase of estradiol (E2) release.
    2 context sentences
    Summary · context
    Therefore the effects of both compounds on in vitro steroid release of porcine luteal cells harvested from young/middle-aged (day 4-6, day 0 = 1st estrous day) or old (day 12-14) corpora lutea were tested.
    Summary · context
    As corpora lutea (CL) contain at least two different steroidogenic cell populations, fractions of the so called small (SLC) and large (LLC) luteal cells were prepared and tested in separate experiments.
  2. 02LabIn vitro (cells)Efficacy outcome

    In small and large luteal cells from young porcine corpora lutea, oxytocin strongly increased estradiol release.

    In plain wordsIn pig luteal cells from young corpora lutea, oxytocin strongly raised estradiol release.

    Peptide
    Oxytocin
    Outcome
    IncreaseEstradiol release in young luteal cells
    Study

    pign: not reported in source

    porcine small and large luteal cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In SLC as well as LLC from young CL OXT and PGF2 alpha inhibited progesterone (P) production but induced a strong increase of estradiol (E2) release.
    2 context sentences
    Summary · context
    Therefore the effects of both compounds on in vitro steroid release of porcine luteal cells harvested from young/middle-aged (day 4-6, day 0 = 1st estrous day) or old (day 12-14) corpora lutea were tested.
    Summary · context
    As corpora lutea (CL) contain at least two different steroidogenic cell populations, fractions of the so called small (SLC) and large (LLC) luteal cells were prepared and tested in separate experiments.
  3. 03LabIn vitro (cells)Efficacy outcome

    In small and large luteal cells from old porcine corpora lutea, oxytocin remained inhibitory to progesterone release.

    In plain wordsIn pig luteal cells from old corpora lutea, oxytocin still lowered progesterone release.

    Peptide
    Oxytocin
    Outcome
    DecreaseProgesterone release in old luteal cells
    Study

    pign: not reported in source

    porcine small and large luteal cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In old SLC and LLC OXT and PGF2 alpha were still inhibitory to P release but OXT was ineffective and PGF2 alpha had a moderate stimulatory effect on luteal E2 secretion.
    2 context sentences
    Summary · context
    Therefore the effects of both compounds on in vitro steroid release of porcine luteal cells harvested from young/middle-aged (day 4-6, day 0 = 1st estrous day) or old (day 12-14) corpora lutea were tested.
    Summary · context
    As corpora lutea (CL) contain at least two different steroidogenic cell populations, fractions of the so called small (SLC) and large (LLC) luteal cells were prepared and tested in separate experiments.
  4. 04LabIn vitro (cells)Efficacy outcome

    In small and large luteal cells from old porcine corpora lutea, oxytocin was ineffective on estradiol secretion.

    In plain wordsIn pig luteal cells from old corpora lutea, oxytocin did not change estradiol secretion.

    Peptide
    Oxytocin
    Outcome
    No significant changeEstradiol secretion in old luteal cells
    Study

    pign: not reported in source

    porcine small and large luteal cells
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In old SLC and LLC OXT and PGF2 alpha were still inhibitory to P release but OXT was ineffective and PGF2 alpha had a moderate stimulatory effect on luteal E2 secretion.
    2 context sentences
    Summary · context
    Therefore the effects of both compounds on in vitro steroid release of porcine luteal cells harvested from young/middle-aged (day 4-6, day 0 = 1st estrous day) or old (day 12-14) corpora lutea were tested.
    Summary · context
    As corpora lutea (CL) contain at least two different steroidogenic cell populations, fractions of the so called small (SLC) and large (LLC) luteal cells were prepared and tested in separate experiments.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 05LabNot a test of Oxytocin aloneIn vitro (cells)Mechanism

    In small luteal cells, added estradiol counteracted the inhibition of progesterone release caused by oxytocin and PGF2 alpha.

    In plain wordsIn pig luteal cells, adding estradiol reversed the progesterone drop caused by oxytocin and PGF2 alpha.

    Peptide
    Oxytocin
    Outcome
    IncreaseReversal of oxytocin inhibition of progesterone release by estradiol
    Study

    pign: not reported in source

    porcine small and large luteal cells
    Comparator
    Oxytocin without estradiol
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Indeed, the pronounced inhibitory effect of OXT and PGF2 alpha on P release from SLC could be counteracted by the addition of exogenous E2 to the culture media.
    2 context sentences
    Summary · context
    Therefore the effects of both compounds on in vitro steroid release of porcine luteal cells harvested from young/middle-aged (day 4-6, day 0 = 1st estrous day) or old (day 12-14) corpora lutea were tested.
    Summary · context
    As corpora lutea (CL) contain at least two different steroidogenic cell populations, fractions of the so called small (SLC) and large (LLC) luteal cells were prepared and tested in separate experiments.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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