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Study · Measured the body's own peptide · 1993

2 results

Vasoactive intestinal polypeptide precursor mRNA exhibits diurnal variation in the rat suprachiasmatic nuclei.

Yang J, Cagampang FR, Nakayama Y, Inouye SI

Brain research. Molecular brain research1 Nov 1993Cited by 30 (Europe PMC)

PMID8302164 (opens in a new tab)DOI10.1016/0169-328x(93)90049-u (opens in a new tab)PepBankPUB-08302164
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, VIP precursor mRNA in the suprachiasmatic nucleus was most abundant in the dark phase, and light exposure suppressed it.

    In plain wordsIn rats, the body's own VIP messenger RNA in the brain clock region was highest in the dark and fell with light.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseVIP precursor mRNA in the suprachiasmatic nucleus during light exposure
    Study

    ratn: not reported in source

    rats under light-dark conditions
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    VIP precursor mRNA was found most abundant during the dark phase, as light exposure suppressed VIP precursor mRNA.
    1 context sentence
    Summary · context
    Diurnal rhythms of VIP precursor mRNA in the SCN was determined in the present study by Northern blot hybridization with an antisense RNA probe in rats kept under light-dark conditions.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, the light-induced suppression of VIP precursor mRNA did not last, and the mRNA returned to the level before the onset of light after 8 h in light.

    In plain wordsIn rats, the body's own VIP messenger RNA in the brain clock region went back to its earlier level after 8 hours of light.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP precursor mRNA after 8 h of light
    Study

    ratn: not reported in source

    rats under light-dark conditions
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    This suppression, however, did not last throughout the light phase and VIP precursor mRNA returned to the level before the onset of light after 8 h in light, suggesting that VIP mRNA responds to photic cues and not to light per se.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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