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Study · Animal study (in vivo) · chick · 1993

4 results

Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival.

Neff NT, Prevette D, Houenou LJ, Lewis ME, Glicksman MA, Yin QW, Oppenheim RW

Journal of neurobiology1 Dec 1993Cited by 172 (Europe PMC)

PMID8301266 (opens in a new tab)DOI10.1002/neu.480241203 (opens in a new tab)PepBankPUB-08301266
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In chick embryos, long R3 IGF-I enhanced motoneuron survival to the same extent as IGF-I.

    In plain wordsIn chick embryos, long R3 IGF-I helped motor neurons survive about as well as IGF-I did.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseMotoneuron survival during developmental neuronal death
    Study

    chickn: not reported in source

    Chick embryos treated in ovo
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · in ovoAs given in this study (chick).

    Source sentences

    Summary
    IGF-II and two variants of IGF-I with reduced affinity for IGF binding proteins, des(1-3) IGF-I and long R3 IGF-I, also elicited enhanced survival of motoneurons equal to that seen in IGF-I-treated embryos.
    1 context sentence
    Summary · context
    Treatment of chick embryos in ovo with IGF-I during the period of normal, developmentally regulated neuronal death (embryonic days 5-10) resulted in a dose-dependent rescue of a significant number of lumbar motoneurons from degeneration and death.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In chick embryos, des(1‑3)IGF-I enhanced motoneuron survival equally to IGF-I treatment.

    In plain wordsIn chick embryos, des(1‑3)IGF-I increased motoneuron survival as much as IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeMotoneuron survival
    Study

    chickn: not reported in source

    chick embryos in ovo
    Comparator
    IGF-I-treated embryos
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-II and two variants of IGF-I with reduced affinity for IGF binding proteins, des(1-3) IGF-I and long R3 IGF-I, also elicited enhanced survival of motoneurons equal to that seen in IGF-I-treated embryos.
    1 context sentence
    Summary · context
    Treatment of chick embryos in ovo with IGF-I during the period of normal, developmentally regulated neuronal death (embryonic days 5-10) resulted in a dose-dependent rescue of a significant number of lumbar motoneurons from degeneration and death.
  3. 03LabIn vitro (cells)Activity measurement

    In embryonic rat spinal cord cultures, des(1‑3)IGF-I elevated choline acetyltransferase activity.

    In plain wordsIn cells from embryonic rat spinal cords, des(1‑3)IGF-I increased choline acetyltransferase activity.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseCholine acetyltransferase activity
    Study

    ratn: not reported in source

    embryonic rat spinal cord cultures
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Consistent with the survival-promoting activity on motoneurons in ovo, IGF-I, -II, and des(1-3) IGF-I elevated choline acetyltransferase activity in embryonic rat spinal cord cultures, with des(1-3) IGF-I demonstrating 2.5 times greater potency than did IGF-I.
  4. 04LabIn vitro (cells)Activity measurement

    In embryonic rat spinal cord cultures, des(1‑3)IGF-I showed 2.5 times greater potency than IGF-I for choline acetyltransferase activity.

    In plain wordsIn cells from embryonic rat spinal cords, des(1‑3)IGF-I increased enzyme activity more potently than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreasePotency for choline acetyltransferase activity
    Study

    ratn: not reported in source

    embryonic rat spinal cord cultures
    Comparator
    IGF-I
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Relative potency
    2.5 times
    des(1-3)IGF-I versus IGF-I

    Source sentences

    Summary
    Consistent with the survival-promoting activity on motoneurons in ovo, IGF-I, -II, and des(1-3) IGF-I elevated choline acetyltransferase activity in embryonic rat spinal cord cultures, with des(1-3) IGF-I demonstrating 2.5 times greater potency than did IGF-I.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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