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Study · Animal study (in vivo) · rat · 1993

28 results

Parathyroid hormone (1-34) and (1-84) stimulate cortical bone formation both from periosteum and endosteum.

Oxlund H, Ejersted C, Andreassen TT, Tørring O, Nilsson MH

Calcified tissue international1 Dec 1993Cited by 82 (Europe PMC)

PMID8293353 (opens in a new tab)DOI10.1007/bf03549782 (opens in a new tab)PepBankPUB-08293353
Publisher pagePubMedAsk about this study
Jump to 28 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study28

28 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment increased periosteal bone formation rate dose dependently.

    In plain wordsIn rats, PTH increased bone formation at the outer surface with increasing dose.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePeriosteal bone formation rate
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment increased endosteal bone formation rate dose dependently.

    In plain wordsIn rats, PTH increased bone formation at the inner surface with increasing dose.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseEndosteal bone formation rate
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment increased bone mass.

    In plain wordsIn rats, PTH increased bone mass.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBone mass
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment did not change bone length.

    In plain wordsIn rats, PTH did not change bone length.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBone length
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment did not change body weight gain.

    In plain wordsIn rats, PTH did not change body weight gain.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBody weight gain
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment expanded the areas undergoing bone mineral apposition without changing the spatial pattern.

    In plain wordsIn rats, PTH expanded areas where bone mineral accumulated without changing the spatial pattern.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseMineral apposition area
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    This pattern of bone modeling was also found in the PTH-treated animals, although more and more areas were included in bone mineral apposition.
    2 context sentences
    Summary · context
    The highest mineral apposition rate, as analyzed by tetracycline labeling, was found at the periosteal postero-medial aspect and at the endosteal anterior aspect.
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment did not change cortical bone porosity.

    In plain wordsIn rats, PTH did not change cortical bone porosity.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCortical porosity
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    The PTH treatments did not change the porosity of the cortical bone nor the concentration and biochemical stability of the collagen.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment did not change collagen concentration.

    In plain wordsIn rats, PTH did not change bone collagen concentration.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCollagen concentration
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    The PTH treatments did not change the porosity of the cortical bone nor the concentration and biochemical stability of the collagen.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH treatment did not change collagen biochemical stability.

    In plain wordsIn rats, PTH did not change bone collagen stability.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeCollagen biochemical stability
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    The PTH treatments did not change the porosity of the cortical bone nor the concentration and biochemical stability of the collagen.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In rats, the highest PTH doses slightly reduced cortical bone ash concentration.

    In plain wordsIn rats, the highest PTH doses slightly reduced cortical bone ash concentration.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseCortical ash concentration
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    The highest doses of PTH resulted in a slight reduction in the ash concentration of cortical bone.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH(1-34) and PTH(1-84) had similar effects on bone formation rate.

    In plain wordsIn rats, PTH(1-34) and PTH(1-84) had similar effects on bone formation rate.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBone formation rate versus PTH(1-84)
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    PTH (1-84)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    No differences were found between the effects of PTH (1-34) and PTH (1-84) on bone formation rate, bone mass, porosity, and biochemical parameters.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH(1-34) and PTH(1-84) had similar effects on bone mass.

    In plain wordsIn rats, PTH(1-34) and PTH(1-84) had similar effects on bone mass.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBone mass versus PTH(1-84)
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    PTH (1-84)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    No differences were found between the effects of PTH (1-34) and PTH (1-84) on bone formation rate, bone mass, porosity, and biochemical parameters.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH(1-34) and PTH(1-84) had similar effects on bone porosity.

    In plain wordsIn rats, PTH(1-34) and PTH(1-84) had similar effects on bone porosity.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changePorosity versus PTH(1-84)
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    PTH (1-84)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    No differences were found between the effects of PTH (1-34) and PTH (1-84) on bone formation rate, bone mass, porosity, and biochemical parameters.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PTH(1-34) and PTH(1-84) had similar effects on biochemical parameters.

    In plain wordsIn rats, PTH(1-34) and PTH(1-84) had similar effects on biochemical parameters.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeBiochemical parameters versus PTH(1-84)
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    PTH (1-84)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    No differences were found between the effects of PTH (1-34) and PTH (1-84) on bone formation rate, bone mass, porosity, and biochemical parameters.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In rats, human PTH(1-84) increased periosteal bone formation rate at the femoral middiaphysis in a dose-related manner.

    In plain wordsIn rats, human PTH(1-84) increased bone formation at the outer femoral surface in a dose-related manner.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreasePeriosteal bone formation rate
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Control animals
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    2 context sentences
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
    Summary · context
    Consequently, intermittent treatment with PTH increased the formation of cortical bone dose dependently, at both the periosteum and the endosteum and increased the bone mass of these growing rats, with no change in the body weight gain or femoral growth rate compared with the control animals.
  16. 16AnimalAnimal study (in vivo)Efficacy outcome

    In rats, human PTH(1-84) increased endosteal bone formation rate at the femoral middiaphysis in a dose-related manner.

    In plain wordsIn rats, human PTH(1-84) increased bone formation at the inner femoral surface in a dose-related manner.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseEndosteal bone formation rate
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Control animals
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    2 context sentences
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
    Summary · context
    Consequently, intermittent treatment with PTH increased the formation of cortical bone dose dependently, at both the periosteum and the endosteum and increased the bone mass of these growing rats, with no change in the body weight gain or femoral growth rate compared with the control animals.
  17. 17AnimalAnimal study (in vivo)Efficacy outcome

    In rats, human PTH(1-84) increased bone mass.

    In plain wordsIn rats, human PTH(1-84) increased bone mass.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseBone mass
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Control animals
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    2 context sentences
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
    Summary · context
    Consequently, intermittent treatment with PTH increased the formation of cortical bone dose dependently, at both the periosteum and the endosteum and increased the bone mass of these growing rats, with no change in the body weight gain or femoral growth rate compared with the control animals.
  18. 18AnimalAnimal study (in vivo)Efficacy outcome

    In rats, human PTH(1-84) did not change bone lengths.

    In plain wordsIn rats, human PTH(1-84) did not change bone lengths.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeBone length
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Control animals
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    2 context sentences
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
    Summary · context
    Consequently, intermittent treatment with PTH increased the formation of cortical bone dose dependently, at both the periosteum and the endosteum and increased the bone mass of these growing rats, with no change in the body weight gain or femoral growth rate compared with the control animals.
  19. 19AnimalAnimal study (in vivo)Safety outcome

    In rats, human PTH(1-84) did not change body weight gain.

    In plain wordsIn rats, human PTH(1-84) did not change body weight gain.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeBody weight gain
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Control animals
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    A dose-related increase in bone formation rate at the femoral middiaphysis was found at both the periosteum and the endosteum and also an increase in bone mass, with no change in the bone lengths or body weight gain of the rats.
    2 context sentences
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
    Summary · context
    Consequently, intermittent treatment with PTH increased the formation of cortical bone dose dependently, at both the periosteum and the endosteum and increased the bone mass of these growing rats, with no change in the body weight gain or femoral growth rate compared with the control animals.
  20. 20AnimalAnimal study (in vivo)Mechanism

    In rats, human PTH(1-84) treatment included more areas in bone mineral apposition while preserving the reported spatial pattern.

    In plain wordsIn rats, human PTH(1-84) increased the areas forming bone while preserving the reported spatial pattern.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    IncreaseAreas of bone mineral apposition
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    This pattern of bone modeling was also found in the PTH-treated animals, although more and more areas were included in bone mineral apposition.
    2 context sentences
    Summary · context
    The highest mineral apposition rate, as analyzed by tetracycline labeling, was found at the periosteal postero-medial aspect and at the endosteal anterior aspect.
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  21. 21AnimalAnimal study (in vivo)Efficacy outcome

    In rats, human PTH(1-84) did not change cortical bone porosity.

    In plain wordsIn rats, human PTH(1-84) did not change cortical bone porosity.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeCortical bone porosity
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    The PTH treatments did not change the porosity of the cortical bone nor the concentration and biochemical stability of the collagen.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  22. 22AnimalAnimal study (in vivo)Mechanism

    In rats, human PTH(1-84) did not change cortical bone collagen concentration.

    In plain wordsIn rats, human PTH(1-84) did not change cortical bone collagen concentration.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeCollagen concentration
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    The PTH treatments did not change the porosity of the cortical bone nor the concentration and biochemical stability of the collagen.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  23. 23AnimalAnimal study (in vivo)Mechanism

    In rats, human PTH(1-84) did not change cortical bone collagen biochemical stability.

    In plain wordsIn rats, human PTH(1-84) did not change cortical bone collagen stability.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeCollagen biochemical stability
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    The PTH treatments did not change the porosity of the cortical bone nor the concentration and biochemical stability of the collagen.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  24. 24AnimalAnimal study (in vivo)Mechanism

    In rats, the highest human PTH(1-84) doses slightly reduced cortical bone ash concentration.

    In plain wordsIn rats, the highest human PTH(1-84) doses slightly reduced cortical bone ash concentration.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    DecreaseCortical bone ash concentration
    Study

    ratn: not reported in source

    Growing rats
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    highest doses, values not separately specified · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    The highest doses of PTH resulted in a slight reduction in the ash concentration of cortical bone.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  25. 25AnimalAnimal study (in vivo)Efficacy outcome

    In rats, human PTH(1-84) and PTH(1-34) did not differ in their effects on bone formation rate.

    In plain wordsIn rats, human PTH(1-84) and PTH(1-34) did not differ in their effects on bone formation rate.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeBone formation rate versus PTH(1-34)
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Human PTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    No differences were found between the effects of PTH (1-34) and PTH (1-84) on bone formation rate, bone mass, porosity, and biochemical parameters.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  26. 26AnimalAnimal study (in vivo)Efficacy outcome

    In rats, human PTH(1-84) and PTH(1-34) did not differ in their effects on bone mass.

    In plain wordsIn rats, human PTH(1-84) and PTH(1-34) did not differ in their effects on bone mass.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeBone mass versus PTH(1-34)
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Human PTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    No differences were found between the effects of PTH (1-34) and PTH (1-84) on bone formation rate, bone mass, porosity, and biochemical parameters.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  27. 27AnimalAnimal study (in vivo)Efficacy outcome

    In rats, human PTH(1-84) and PTH(1-34) did not differ in their effects on bone porosity.

    In plain wordsIn rats, human PTH(1-84) and PTH(1-34) did not differ in their effects on bone porosity.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changePorosity versus PTH(1-34)
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Human PTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    No differences were found between the effects of PTH (1-34) and PTH (1-84) on bone formation rate, bone mass, porosity, and biochemical parameters.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.
  28. 28AnimalAnimal study (in vivo)Mechanism

    In rats, human PTH(1-84) and PTH(1-34) did not differ in their effects on biochemical parameters.

    In plain wordsIn rats, human PTH(1-84) and PTH(1-34) did not differ in their effects on biochemical parameters.

    Peptide
    PTH 1-84 (parathyroid hormone)
    Outcome
    No significant changeBiochemical parameters versus PTH(1-34)
    Study

    ratn: not reported in source

    Growing rats
    Comparator
    Human PTH(1-34)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    1.1, 3.3, 10, and 30 nmol/kg/day · injection · 30 daysAs given in this study (rat).

    Source sentences

    Summary
    No differences were found between the effects of PTH (1-34) and PTH (1-84) on bone formation rate, bone mass, porosity, and biochemical parameters.
    1 context sentence
    Summary · context
    Groups of rats were injected with human PTH (1-34) or PTH (1-84), 1.1, 3.3, 10, and 30 nmol/kg/day for 30 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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