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Study · Randomized controlled trial · n = 20 · 1993

8 results

Short and long-term effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone-deficient males.

Vandeweghe M, Taelman P, Kaufman JM

Clinical endocrinology1 Oct 1993Cited by 96 (Europe PMC)

PMID8287567 (opens in a new tab)DOI10.1111/j.1365-2265.1993.tb02387.x (opens in a new tab)PepBankPUB-08287567
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adult men, GH increased alkaline phosphatase versus placebo after 3 and 6 months (P < 0.01 to P < 0.001).

    In plain wordsIn GH-deficient adult men, GH increased a bone turnover enzyme compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSerum alkaline phosphatase
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.25 IU/kg/week · 3 and 6 monthsAs given in this study (human).

    Source sentences

    Summary
    After 3 and 6 months of GH administration, the serum levels of alkaline phosphatase, osteocalcin and carboxyterminal propeptide of type-I procollagen, and the fasting urinary hydroxyproline/creatinine ratio were significantly increased compared to placebo-treated patients (P < 0.01 to P < 0.001).
    3 context sentences
    Summary · context
    In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content…
    Summary · context
    We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12-24 months of GH treatment in all patients.
    Summary · context
    Twenty adult males with GH deficiency of childhood onset were studied.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adult men, GH increased osteocalcin versus placebo after 3 and 6 months (P < 0.01 to P < 0.001).

    In plain wordsIn GH-deficient adult men, GH increased osteocalcin compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSerum osteocalcin
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.25 IU/kg/week · 3 and 6 monthsAs given in this study (human).

    Source sentences

    Summary
    After 3 and 6 months of GH administration, the serum levels of alkaline phosphatase, osteocalcin and carboxyterminal propeptide of type-I procollagen, and the fasting urinary hydroxyproline/creatinine ratio were significantly increased compared to placebo-treated patients (P < 0.01 to P < 0.001).
    3 context sentences
    Summary · context
    In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content…
    Summary · context
    We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12-24 months of GH treatment in all patients.
    Summary · context
    Twenty adult males with GH deficiency of childhood onset were studied.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adult men, GH increased the procollagen propeptide versus placebo after 3 and 6 months (P < 0.01 to P < 0.001).

    In plain wordsIn GH-deficient adult men, GH increased a collagen production marker compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseCarboxyterminal propeptide of type-I procollagen
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.25 IU/kg/week · 3 and 6 monthsAs given in this study (human).

    Source sentences

    Summary
    After 3 and 6 months of GH administration, the serum levels of alkaline phosphatase, osteocalcin and carboxyterminal propeptide of type-I procollagen, and the fasting urinary hydroxyproline/creatinine ratio were significantly increased compared to placebo-treated patients (P < 0.01 to P < 0.001).
    3 context sentences
    Summary · context
    In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content…
    Summary · context
    We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12-24 months of GH treatment in all patients.
    Summary · context
    Twenty adult males with GH deficiency of childhood onset were studied.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In GH-deficient adult men, GH increased urinary hydroxyproline/creatinine versus placebo after 3 and 6 months (P < 0.01 to P < 0.001).

    In plain wordsIn GH-deficient adult men, GH increased a urine bone turnover marker compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseUrinary hydroxyproline/creatinine ratio
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.25 IU/kg/week · 3 and 6 monthsAs given in this study (human).

    Source sentences

    Summary
    After 3 and 6 months of GH administration, the serum levels of alkaline phosphatase, osteocalcin and carboxyterminal propeptide of type-I procollagen, and the fasting urinary hydroxyproline/creatinine ratio were significantly increased compared to placebo-treated patients (P < 0.01 to P < 0.001).
    3 context sentences
    Summary · context
    In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content…
    Summary · context
    We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12-24 months of GH treatment in all patients.
    Summary · context
    Twenty adult males with GH deficiency of childhood onset were studied.
  5. 05HumanNon-randomized trialEfficacy outcome

    In GH-deficient adult men, bone turnover indices remained above pretreatment levels during open GH treatment, with a downward trend after about one year.

    In plain wordsIn GH-deficient adult men, bone turnover markers remained elevated during open GH treatment, then showed a downward trend.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseBone turnover indices during open extension
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.25 IU/kg/week · 12 monthsAs given in this study (human).

    Source sentences

    Summary
    During the open study phase, the values for these indices of bone turnover remained elevated above pretreatment levels (P < 0.01 to P < 0.001 at 12 months), a downward trend becoming apparent after about one year of GH treatment.
    3 context sentences
    Summary · context
    In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content…
    Summary · context
    We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12-24 months of GH treatment in all patients.
    Summary · context
    Twenty adult males with GH deficiency of childhood onset were studied.
  6. 06HumanNon-randomized trialEfficacy outcome

    In GH-deficient adult men, bone mineral content initially declined after 3 months of GH treatment.

    In plain wordsIn GH-deficient adult men, bone mineral content initially decreased during GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseEarly bone mineral content
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.25 IU/kg/week · 3 monthsAs given in this study (human).

    Source sentences

    Summary
    BMC values showed an initial decline after 3 months of GH treatment
    3 context sentences
    Summary · context
    In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content…
    Summary · context
    We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12-24 months of GH treatment in all patients.
    Summary · context
    Twenty adult males with GH deficiency of childhood onset were studied.
  7. 07HumanNon-randomized trialEfficacy outcome

    In GH-deficient adult men, lumbar spine total bone mineral content increased 7.8% above pretreatment after 30 months of GH administration.

    In plain wordsIn GH-deficient adult men, lumbar spine bone mineral content increased above baseline during longer GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseLumbar spine bone mineral content at 30 months
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.25 IU/kg/week · 30 monthsAs given in this study (human).

    Measurements

    BMC increase
    7.8%
    lumbar spine L2-L4 at 30 months

    Source sentences

    Summary
    followed by a significant and progressive increase above pretreatment values, reaching 7.8% for total BMC at the lumbar spine (L2-L4) and 9.9% for total BMC at the forearm, after 30 months of GH administration.
    3 context sentences
    Summary · context
    In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content…
    Summary · context
    We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12-24 months of GH treatment in all patients.
    Summary · context
    Twenty adult males with GH deficiency of childhood onset were studied.
  8. 08HumanNon-randomized trialEfficacy outcome

    In GH-deficient adult men, forearm total bone mineral content increased 9.9% above pretreatment after 30 months of GH administration.

    In plain wordsIn GH-deficient adult men, forearm bone mineral content increased above baseline during longer GH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseForearm bone mineral content at 30 months
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    0.25 IU/kg/week · 30 monthsAs given in this study (human).

    Measurements

    BMC increase
    9.9%
    forearm at 30 months

    Source sentences

    Summary
    followed by a significant and progressive increase above pretreatment values, reaching 7.8% for total BMC at the lumbar spine (L2-L4) and 9.9% for total BMC at the forearm, after 30 months of GH administration.
    3 context sentences
    Summary · context
    In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content…
    Summary · context
    We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12-24 months of GH treatment in all patients.
    Summary · context
    Twenty adult males with GH deficiency of childhood onset were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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