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Study · Animal study (in vivo) · rat · 1993

4 results

Effects of oxytocin and uterine and luteal prostaglandins on the functional regression of the corpus luteum in pseudopregnant rats.

Cao L, Chan WY

Journal of reproduction and fertility1 Sept 1993Cited by 18 (Europe PMC)

PMID8283436 (opens in a new tab)DOI10.1530/jrf.0.0990181 (opens in a new tab)PepBankPUB-08283436
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In pseudopregnant rats, oxytocin shortened pseudopregnancy compared with saline.

    In plain wordsIn pseudopregnant rats, oxytocin shortened pseudopregnancy compared with saline.

    Peptide
    Oxytocin
    Outcome
    DecreaseDuration of pseudopregnancy
    Study

    ratn: not reported in source

    pseudopregnant rats
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mU twice a day · subcutaneous · 3 daysAs given in this study (rat).

    Measurements

    pseudopregnancy duration
    13.5 days
    control
    pseudopregnancy duration
    11.5 days
    oxytocin

    Source sentences

    Summary
    Oxytocin injections shortened the duration of pseudopregnancy from the mean of 13.5 +/- 0.3 days for the control group to 11.5 +/- 0.3 days for the oxytocin-treated group (P < 0.01).
    3 context sentences
    Summary · context
    Pseudopregnancy was induced in normal cyclic rats by gonadotrophin treatment.
    Summary · context
    One group was given oxytocin, 500 mU s.c., twice a day for three days.
    Summary · context
    A control group was given saline injections.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pseudopregnant rats, the oxytocin-induced shortening of pseudopregnancy was associated with premature functional regression of the corpus luteum.

    In plain wordsIn pseudopregnant rats, oxytocin was linked to earlier loss of corpus luteum function.

    Peptide
    Oxytocin
    Outcome
    IncreaseFunctional regression of the corpus luteum
    Study

    ratn: not reported in source

    pseudopregnant rats
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mU twice a day · subcutaneous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    The oxytocin-induced shortening of pseudopregnancy was associated with a premature functional regression of the corpus luteum.
    3 context sentences
    Summary · context
    Pseudopregnancy was induced in normal cyclic rats by gonadotrophin treatment.
    Summary · context
    One group was given oxytocin, 500 mU s.c., twice a day for three days.
    Summary · context
    A control group was given saline injections.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In pseudopregnant rats, oxytocin treatment stimulated uterine PGF2 alpha synthesis.

    In plain wordsIn pseudopregnant rats, oxytocin increased PGF2 alpha made in the uterus.

    Peptide
    Oxytocin
    Outcome
    IncreaseUterine PGF2 alpha synthesis
    Study

    ratn: not reported in source

    pseudopregnant rats
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mU twice a day · subcutaneous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    However, only uterine PGF2 alpha synthesis was stimulated by oxytocin treatment.
    3 context sentences
    Summary · context
    Pseudopregnancy was induced in normal cyclic rats by gonadotrophin treatment.
    Summary · context
    One group was given oxytocin, 500 mU s.c., twice a day for three days.
    Summary · context
    A control group was given saline injections.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pseudopregnant rats, oxytocin treatment did not stimulate luteal PGF2 alpha synthesis.

    In plain wordsIn pseudopregnant rats, oxytocin did not raise PGF2 alpha made in the corpus luteum.

    Peptide
    Oxytocin
    Outcome
    No significant changeLuteal PGF2 alpha synthesis
    Study

    ratn: not reported in source

    pseudopregnant rats
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    500 mU twice a day · subcutaneous · 3 daysAs given in this study (rat).

    Source sentences

    Summary
    However, only uterine PGF2 alpha synthesis was stimulated by oxytocin treatment.
    3 context sentences
    Summary · context
    Pseudopregnancy was induced in normal cyclic rats by gonadotrophin treatment.
    Summary · context
    One group was given oxytocin, 500 mU s.c., twice a day for three days.
    Summary · context
    A control group was given saline injections.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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