Commonalities in vasoactive intestinal peptide and peptide N-terminal histidine C-terminal isoleucine stimulation of N-acetyltransferase activity in the rat pineal.

Yuwiler A, Brammer GL, Bennett BL

Journal of pineal research1 Sept 1993Cited by 4 (Europe PMC)

PMID8283388DOI10.1111/j.1600-079x.1993.tb00513.xPepBankPUB-08283388

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In rat pineal glands in organ culture, VIP increased serotonin N-acetyltransferase activity.
In plain wordsIn lab-cultured rat pineal glands, VIP raised the activity of an enzyme needed to make melatonin.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePineal serotonin N-acetyltransferase (NAT) activity
Study
ratn: not reported in source
adult rat pineal glands in organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Exposure of adult rat pineal glands in organ culture to the polypeptides vasoactive intestinal polypeptide (VIP), and peptide N-terminal histidine C-terminal isoleucine (PHI) increases pineal serotonin N-acetyltransferase (NAT) activity
1 context sentence(design, population, supporting numbers)
Summary · context
Exposure of adult rat pineal glands in organ culture to the polypeptides vasoactive intestinal polypeptide (VIP), and peptide N-terminal histidine C-terminal isoleucine (PHI) increases pineal serotonin N-acetyltransferase (NAT) activity and melatonin synthesis.
Report a problemFND-0828338801
02LabEx vivo tissueMechanism
In rat pineal glands in organ culture, VIP increased melatonin synthesis.
In plain wordsIn lab-cultured rat pineal glands, VIP increased melatonin production.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreasePineal melatonin synthesis
Study
ratn: not reported in source
adult rat pineal glands in organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Exposure of adult rat pineal glands in organ culture to the polypeptides vasoactive intestinal polypeptide (VIP), and peptide N-terminal histidine C-terminal isoleucine (PHI) increases pineal serotonin N-acetyltransferase (NAT) activity and melatonin synthesis.
Report a problemFND-0828338802
03LabEx vivo tissueMechanism
In rat pineal glands, pineals taken after 3 hr of light were much less sensitive to VIP stimulation than those taken after 13 hr of light.
In plain wordsIn lab-cultured rat pineals, glands taken after 3 hours of light responded much less to VIP than those taken after 13 hours.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseEffect of prior light exposure on VIP-stimulated NAT activity
Study
ratn: not reported in source
adult rat pineal glands in organ culture
Comparator
Pineals taken after 13 hr of light
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
(3) Light exposure affects the sensitivity of pineals to VIP and PHI stimulation in a similar manner; pineals taken after 3 hr of light are much less sensitive to PHI or VIP than those taken after 13 hr of light.
Report a problemFND-0828338804
04LabEx vivo tissueMechanism
In rat pineal glands, 48 hr exposure to VIP reduced the NAT response to VIP, and the reduction was reversible after culture in agonist-free media.
In plain wordsIn lab-cultured rat pineals, two days of VIP lowered the response to VIP, and the response came back after VIP was removed.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseNAT response after 48 hr exposure to VIP
Study
ratn: not reported in source
adult rat pineal glands in organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · 48 hrAs given in this study (rat).
Source sentences
Summary
(4) Pineals exposed for 48 hr to either PHI or VIP have a reduced NAT response to either agonist, which is reversible by culture in agonist-free media.
Report a problemFND-0828338805

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

05LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism
In rat pineal glands, the effects of VIP and PHI together on NAT activity were additive at 10 nM VIP and 100 nM PHI but not at higher concentrations.
In plain wordsIn lab-cultured rat pineals, VIP and PHI together added up at low doses but not at higher doses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
MixedNAT activity with VIP plus PHI
Study
ratn: not reported in source
adult rat pineal glands in organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
The effects of the two peptides are additive at concentrations of 10 nM VIP and 100 nM PHI but not at higher peptide concentrations
1 context sentence(design, population, supporting numbers)
Summary · context
Exposure of adult rat pineal glands in organ culture to the polypeptides vasoactive intestinal polypeptide (VIP), and peptide N-terminal histidine C-terminal isoleucine (PHI) increases pineal serotonin N-acetyltransferase (NAT) activity and melatonin synthesis.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0828338803
06LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueMechanism
In rat pineal glands, VIP-stimulated NAT activity was not affected by the VIP antagonists NAcTDGRF, L-8-K, VIPNET or 4C1PLVIP.
In plain wordsIn lab-cultured rat pineals, four VIP antagonists did not change the NAT response to VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeVIP-stimulated NAT activity with VIP antagonists
Study
ratn: not reported in source
adult rat pineal glands in organ culture
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
(5) Neither VIP nor PHI stimulation of NAT activity is affected by concentrations of the VIP antagonists (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 (NAcTDGRF), L-8-K, VIP-Neurotensin Hybrid (VIPNET), or (4Cl-D-Phe6, Leu17)-VIP (4C1PLVIP), which affect VIP binding or function in other tissues.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0828338806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 2
9 Oct 2026, 12:41 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Commonalities in vasoactive intestinal peptide and peptide N-terminal histidine C-terminal isoleucine stimulation of N-acetyltransferase activity in the rat pineal.

Summary

Results from this study6

Studies that did not test the peptide alone2

Version history

Subjects

Publication types

MeSH terms