In rat osteoclast culture experiments, salmon calcitonin inhibited T3-induced stimulation of bone resorption.
In plain wordsIn lab tests with rat bone cells, calcitonin inhibited thyroid-hormone-induced bone resorption compared with thyroid hormone alone.
- Peptide
- Calcitonin-salmon
- Outcome
- DecreaseT3-induced bone resorption
- Study
ratn: not reported in source
Osteoblast-osteoclast cultures- Comparator
- T3 stimulation without salmon calcitonin
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- 10(-10) MAs given in this study (rat).
Source sentences
T3-induced stimulation was inhibited by salmon calcitonin (10(-10) M).
1 context sentence(design, population, supporting numbers)
To determine the effect of T3 on bone resorption, we used an isolated rat osteoclast bone resorption assay in the absence or presence of added osteoblasts.