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Study · Animal study (in vivo) · cattle · 1993

4 results

Efficacy of intramammary antibiotic therapy for treatment of clinical mastitis caused by environmental pathogens.

Guterbock WM, Van Eenennaam AL, Anderson RJ, Gardner IA, Cullor JS, Holmberg CA

Journal of dairy science1 Nov 1993Cited by 77 (Europe PMC)

PMID8270686 (opens in a new tab)DOI10.3168/jds.s0022-0302(93)77682-1 (opens in a new tab)PepBankPUB-08270686
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In dairy cow quarters with mild clinical mastitis, intramuscular oxytocin did not differ from intramammary amoxicillin or cephapirin in clinical cure rate.

    In plain wordsIn cows with mild mastitis, oxytocin and the two antibiotics did not differ in how many quarters were cured.

    Peptide
    Oxytocin
    Outcome
    No significant changeClinical cure rate
    Study

    cattlen = 254

    mild clinical mastitis in dairy cow quarters
    Comparator
    Intramammary amoxicillin or cephapirin
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    100 units every 12 h · intramuscular · two or three milkingsAs given in this study (cattle).

    Source sentences

    Summary
    No difference existed in clinical (67.6, 67.7, or 66.7%) or bacterial (43.9, 55.0 or 49.1%) cure rate among groups.
    2 context sentences
    Summary · context
    For three California dairy herds with bulk tank SCC < 200,000/ml, twice daily milking, and no mastitis vaccine, 254 quarters with mild clinical mastitis were randomly assigned to three groups.
    Summary · context
    Group O (n = 105) was treated with 100 units of intramuscular oxytocin every 12 h for two or three milkings.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In dairy cow quarters with mild clinical mastitis, intramuscular oxytocin did not differ from intramammary amoxicillin or cephapirin in bacterial cure rate.

    In plain wordsIn cows with mild mastitis, oxytocin and the two antibiotics did not differ in how many quarters were cleared of bacteria.

    Peptide
    Oxytocin
    Outcome
    No significant changeBacterial cure rate
    Study

    cattlen = 254

    mild clinical mastitis in dairy cow quarters
    Comparator
    Intramammary amoxicillin or cephapirin
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    100 units every 12 h · intramuscular · two or three milkingsAs given in this study (cattle).

    Source sentences

    Summary
    No difference existed in clinical (67.6, 67.7, or 66.7%) or bacterial (43.9, 55.0 or 49.1%) cure rate among groups.
    2 context sentences
    Summary · context
    For three California dairy herds with bulk tank SCC < 200,000/ml, twice daily milking, and no mastitis vaccine, 254 quarters with mild clinical mastitis were randomly assigned to three groups.
    Summary · context
    Group O (n = 105) was treated with 100 units of intramuscular oxytocin every 12 h for two or three milkings.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    Clinical cure rates did not differ among groups when mastitis quarters were grouped by etiology.

    In plain wordsIn cows with mastitis, cure rates with oxytocin did not differ from antibiotics when quarters were grouped by cause.

    Peptide
    Oxytocin
    Outcome
    No significant changeClinical cure rate by etiology
    Study

    cattlen: not reported in source

    mild clinical mastitis in dairy cow quarters
    Comparator
    Intramammary amoxicillin or cephapirin
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    100 units every 12 h · intramuscular · two or three milkingsAs given in this study (cattle).

    Source sentences

    Summary
    Clinical cure rates did not differ when quarters were grouped by etiology
    2 context sentences
    Summary · context
    For three California dairy herds with bulk tank SCC < 200,000/ml, twice daily milking, and no mastitis vaccine, 254 quarters with mild clinical mastitis were randomly assigned to three groups.
    Summary · context
    Group O (n = 105) was treated with 100 units of intramuscular oxytocin every 12 h for two or three milkings.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In quarters infected with pathogens other than streptococci or coliforms, the clinical cure rate was lower with oxytocin than with the other groups.

    In plain wordsIn cows with mastitis from other bacteria, oxytocin cured fewer quarters than the antibiotics did.

    Peptide
    Oxytocin
    Outcome
    DecreaseClinical cure rate for pathogens other than streptococci or coliforms
    Study

    cattlen: not reported in source

    mild clinical mastitis in dairy cow quarters
    Comparator
    Intramammary amoxicillin or cephapirin
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    100 units every 12 h · intramuscular · two or three milkingsAs given in this study (cattle).

    Source sentences

    Summary
    but clinical cure rates for quarters with pathogens other than streptococci or coliforms were lower in group O.
    2 context sentences
    Summary · context
    For three California dairy herds with bulk tank SCC < 200,000/ml, twice daily milking, and no mastitis vaccine, 254 quarters with mild clinical mastitis were randomly assigned to three groups.
    Summary · context
    Group O (n = 105) was treated with 100 units of intramuscular oxytocin every 12 h for two or three milkings.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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