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Study · Ex vivo tissue · rat and rat (brattleboro) · 1993

6 results

Lack of effect of oxytocin on the numbers of "synaptic" ribbons, cyclic guanosine monophosphate and serotonin N-acetyltransferase activity in organ-cultured pineals of three strains of rats.

Reuss S, Mattern E, Spessert R, Riemann R, Weber A, Vollrath L

Cell and tissue research1 Nov 1993Cited by 2 (Europe PMC)

PMID8269481 (opens in a new tab)DOI10.1007/bf00318752 (opens in a new tab)PepBankPUB-08269481
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In organ-cultured rat pineals, oxytocin did not change synaptic ribbon numbers compared with control in any of three strains.

    In plain wordsIn rat pineal glands in culture, oxytocin did not change synaptic ribbon numbers compared with control.

    Peptide
    Oxytocin
    Outcome
    No significant changeSynaptic ribbon numbers
    Study

    ratn: not reported in source

    organ-cultured pineal glands
    Comparator
    Control
    Outcome group
    Circadian rhythm · Endocrine and hormones
    Studied dose
    10(-5) MAs given in this study (rat).

    Source sentences

    Summary
    Neither morphological nor biochemical analyses showed a difference between control and OT-incubated organs in any of the strains tested.
    2 context sentences
    Summary · context
    We therefore studied "synaptic" ribbon (SR) numbers, N-acetyltransferase (NAT) activity and the intracellular concentration of cyclic guanosine monophosphate (cGMP) following in vitro incubation of rat pineals in media containing OT (10(-5) M), noradrenaline (NA, 10(-5) M) or both NA and OT.
    Summary · context
    Pineal glands were derived from rats of three different strains (Sprague-Dawley, Long-Evans and the AVP-deficient strain Brattleboro).
  2. 02LabEx vivo tissueEfficacy outcome

    In organ-cultured rat pineals, oxytocin did not change N-acetyltransferase activity compared with control in any of three strains.

    In plain wordsIn rat pineal glands in culture, oxytocin did not change enzyme activity compared with control.

    Peptide
    Oxytocin
    Outcome
    No significant changeN-acetyltransferase activity
    Study

    ratn: not reported in source

    organ-cultured pineal glands
    Comparator
    Control
    Outcome group
    Circadian rhythm · Endocrine and hormones
    Studied dose
    10(-5) MAs given in this study (rat).

    Source sentences

    Summary
    Neither morphological nor biochemical analyses showed a difference between control and OT-incubated organs in any of the strains tested.
    2 context sentences
    Summary · context
    We therefore studied "synaptic" ribbon (SR) numbers, N-acetyltransferase (NAT) activity and the intracellular concentration of cyclic guanosine monophosphate (cGMP) following in vitro incubation of rat pineals in media containing OT (10(-5) M), noradrenaline (NA, 10(-5) M) or both NA and OT.
    Summary · context
    Pineal glands were derived from rats of three different strains (Sprague-Dawley, Long-Evans and the AVP-deficient strain Brattleboro).
  3. 03LabEx vivo tissueEfficacy outcome

    In organ-cultured rat pineals, oxytocin did not change cGMP content compared with control in any of three strains.

    In plain wordsIn rat pineal glands in culture, oxytocin did not change cGMP content compared with control.

    Peptide
    Oxytocin
    Outcome
    No significant changecGMP concentration
    Study

    ratn: not reported in source

    organ-cultured pineal glands
    Comparator
    Control
    Outcome group
    Circadian rhythm · Endocrine and hormones
    Studied dose
    10(-5) MAs given in this study (rat).

    Source sentences

    Summary
    Neither morphological nor biochemical analyses showed a difference between control and OT-incubated organs in any of the strains tested.
    2 context sentences
    Summary · context
    We therefore studied "synaptic" ribbon (SR) numbers, N-acetyltransferase (NAT) activity and the intracellular concentration of cyclic guanosine monophosphate (cGMP) following in vitro incubation of rat pineals in media containing OT (10(-5) M), noradrenaline (NA, 10(-5) M) or both NA and OT.
    Summary · context
    Pineal glands were derived from rats of three different strains (Sprague-Dawley, Long-Evans and the AVP-deficient strain Brattleboro).
  4. 04LabEx vivo tissueEfficacy outcome

    In organ-cultured pineals of Brattleboro rats, the small noradrenaline-induced rise in synaptic ribbon number was not seen when oxytocin was added.

    In plain wordsIn Brattleboro rat pineal glands in culture, adding oxytocin removed the small ribbon increase caused by noradrenaline.

    Peptide
    Oxytocin
    Outcome
    DecreaseNoradrenaline-induced rise in synaptic ribbon number, Brattleboro rats
    Study

    rat (Brattleboro)n: not reported in source

    organ-cultured pineal glands
    Comparator
    Noradrenaline alone
    Outcome group
    Circadian rhythm · Endocrine and hormones
    Studied dose
    10(-5) MAs given in this study (rat (Brattleboro)).

    Source sentences

    Summary
    In Brattleboro rats, but not in the other strains, noradrenaline slightly increased the number of SR which was not observed when NA and OT were combined.
    2 context sentences
    Summary · context
    We therefore studied "synaptic" ribbon (SR) numbers, N-acetyltransferase (NAT) activity and the intracellular concentration of cyclic guanosine monophosphate (cGMP) following in vitro incubation of rat pineals in media containing OT (10(-5) M), noradrenaline (NA, 10(-5) M) or both NA and OT.
    Summary · context
    Pineal glands were derived from rats of three different strains (Sprague-Dawley, Long-Evans and the AVP-deficient strain Brattleboro).
  5. 05LabEx vivo tissueEfficacy outcome

    In organ-cultured rat pineals, oxytocin did not affect the noradrenaline-induced rise in N-acetyltransferase activity.

    In plain wordsIn rat pineal glands in culture, oxytocin did not change the enzyme rise caused by noradrenaline.

    Peptide
    Oxytocin
    Outcome
    No significant changeNoradrenaline-induced N-acetyltransferase activity with oxytocin
    Study

    ratn: not reported in source

    organ-cultured pineal glands
    Comparator
    Noradrenaline alone
    Outcome group
    Circadian rhythm · Endocrine and hormones
    Studied dose
    10(-5) MAs given in this study (rat).

    Source sentences

    Summary
    The addition of NA resulted in distinct augmentation of NAT activity and cGMP content, which were not affected by additional OT application.
    2 context sentences
    Summary · context
    We therefore studied "synaptic" ribbon (SR) numbers, N-acetyltransferase (NAT) activity and the intracellular concentration of cyclic guanosine monophosphate (cGMP) following in vitro incubation of rat pineals in media containing OT (10(-5) M), noradrenaline (NA, 10(-5) M) or both NA and OT.
    Summary · context
    Pineal glands were derived from rats of three different strains (Sprague-Dawley, Long-Evans and the AVP-deficient strain Brattleboro).
  6. 06LabEx vivo tissueEfficacy outcome

    In organ-cultured rat pineals, oxytocin did not affect the noradrenaline-induced rise in cGMP content.

    In plain wordsIn rat pineal glands in culture, oxytocin did not change the cGMP rise caused by noradrenaline.

    Peptide
    Oxytocin
    Outcome
    No significant changeNoradrenaline-induced cGMP content with oxytocin
    Study

    ratn: not reported in source

    organ-cultured pineal glands
    Comparator
    Noradrenaline alone
    Outcome group
    Circadian rhythm · Endocrine and hormones
    Studied dose
    10(-5) MAs given in this study (rat).

    Source sentences

    Summary
    The addition of NA resulted in distinct augmentation of NAT activity and cGMP content, which were not affected by additional OT application.
    2 context sentences
    Summary · context
    We therefore studied "synaptic" ribbon (SR) numbers, N-acetyltransferase (NAT) activity and the intracellular concentration of cyclic guanosine monophosphate (cGMP) following in vitro incubation of rat pineals in media containing OT (10(-5) M), noradrenaline (NA, 10(-5) M) or both NA and OT.
    Summary · context
    Pineal glands were derived from rats of three different strains (Sprague-Dawley, Long-Evans and the AVP-deficient strain Brattleboro).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

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