Skip to content

Study · Animal study (in vivo) · rat · 1993

6 results

Effects of growth hormone and IGF-I on glomerular ultrafiltration in growth hormone-deficient rats.

Hirschberg R

Regulatory peptides1 Oct 1993Cited by 15 (Europe PMC)

PMID8265813 (opens in a new tab)DOI10.1016/0167-0115(93)90353-a (opens in a new tab)PepBankPUB-08265813
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In growth hormone deficient rats, des(1‑3)IGF-I normalized glomerular filtration rate compared with vehicle.

    In plain wordsIn rats, des(1‑3)IGF-I restored kidney filtration rate compared with vehicle.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseGlomerular filtration rate
    Study

    ratn: not reported in source

    Growth hormone deficient dw/dw rats
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · subcutaneous infusion · one weekAs given in this study (rat).

    Source sentences

    Summary
    Glomerular function became normal with growth hormone or IGF-I treatment, respectively.
    2 context sentences
    Summary · context
    Subsequent renal micropuncture and clearance studies revealed a low GFR and single nephron GFR (SNGFR) in vehicle treated growth hormone deficient animals.
    Summary · context
    Growth hormone deficient dw/dw rats received, for one week, subcutaneous infusions of vehicle, des(1-3)IGF-I or were injected i.m. with recombinant human growth hormone.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In growth hormone deficient rats, des(1‑3)IGF-I raised single nephron GFR compared with vehicle.

    In plain wordsIn rats, des(1‑3)IGF-I increased filtration by individual nephrons compared with vehicle.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseSingle nephron GFR
    Study

    ratn: not reported in source

    Growth hormone deficient dw/dw rats
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · subcutaneous infusion · one weekAs given in this study (rat).

    Source sentences

    Summary
    Both treatments raised SNGFR by reducing arteriolar resistance and increasing the glomerular ultrafiltration coefficient.
    1 context sentence
    Summary · context
    Growth hormone deficient dw/dw rats received, for one week, subcutaneous infusions of vehicle, des(1-3)IGF-I or were injected i.m. with recombinant human growth hormone.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In growth hormone deficient rats, des(1‑3)IGF-I reduced arteriolar resistance compared with vehicle.

    In plain wordsIn rats, des(1‑3)IGF-I reduced kidney arteriolar resistance compared with vehicle.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseArteriolar resistance
    Study

    ratn: not reported in source

    Growth hormone deficient dw/dw rats
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · subcutaneous infusion · one weekAs given in this study (rat).

    Source sentences

    Summary
    Both treatments raised SNGFR by reducing arteriolar resistance and increasing the glomerular ultrafiltration coefficient.
    1 context sentence
    Summary · context
    Growth hormone deficient dw/dw rats received, for one week, subcutaneous infusions of vehicle, des(1-3)IGF-I or were injected i.m. with recombinant human growth hormone.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In growth hormone deficient rats, des(1‑3)IGF-I increased the glomerular ultrafiltration coefficient compared with vehicle.

    In plain wordsIn rats, des(1‑3)IGF-I increased the glomerular filtration coefficient compared with vehicle.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseGlomerular ultrafiltration coefficient
    Study

    ratn: not reported in source

    Growth hormone deficient dw/dw rats
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · subcutaneous infusion · one weekAs given in this study (rat).

    Source sentences

    Summary
    Both treatments raised SNGFR by reducing arteriolar resistance and increasing the glomerular ultrafiltration coefficient.
    1 context sentence
    Summary · context
    Growth hormone deficient dw/dw rats received, for one week, subcutaneous infusions of vehicle, des(1-3)IGF-I or were injected i.m. with recombinant human growth hormone.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In growth hormone deficient rats, des(1‑3)IGF-I increased glomerular tuft volume compared with vehicle.

    In plain wordsIn rats, des(1‑3)IGF-I increased glomerular tuft volume compared with vehicle.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseGlomerular tuft volume
    Study

    ratn: not reported in source

    Growth hormone deficient dw/dw rats
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · subcutaneous infusion · one weekAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, the two treatments also increased the glomerular tuft volume and the kidney weight which may contribute to the rise in SNGFR and GFR.
    1 context sentence
    Summary · context
    Growth hormone deficient dw/dw rats received, for one week, subcutaneous infusions of vehicle, des(1-3)IGF-I or were injected i.m. with recombinant human growth hormone.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In growth hormone deficient rats, des(1‑3)IGF-I increased kidney weight compared with vehicle.

    In plain wordsIn rats, des(1‑3)IGF-I increased kidney weight compared with vehicle.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseKidney weight
    Study

    ratn: not reported in source

    Growth hormone deficient dw/dw rats
    Comparator
    Vehicle
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · subcutaneous infusion · one weekAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, the two treatments also increased the glomerular tuft volume and the kidney weight which may contribute to the rise in SNGFR and GFR.
    1 context sentence
    Summary · context
    Growth hormone deficient dw/dw rats received, for one week, subcutaneous infusions of vehicle, des(1-3)IGF-I or were injected i.m. with recombinant human growth hormone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.