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Study · Animal study (in vivo) · mouse · 1993

2 results

Effect of synthetic thymic hormones on the cocaine-induced inhibition of the primary immune response in mice.

Ravagnan G, Falchetti R, Lanzilli G, Di Francesco P, Gaziano R, Favalli C, Garaci E

International journal of immunopharmacology1 Nov 1993Cited by 3 (Europe PMC)

PMID8253538 (opens in a new tab)DOI10.1016/0192-0561(93)90005-j (opens in a new tab)PepBankPUB-08253538
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cocaine-induced impairment, thymosin alpha‑1 induced a significant recovery of the antibody response to sheep red blood cells.

    In plain wordsIn mice whose immune response was weakened by cocaine, thymosin alpha‑1 restored much of the response.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseRecovery of antibody response to SRBC
    Study

    mousen: not reported in source

    Mice with cocaine-induced impairment of the primary antibody response to SRBC
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · During cocaine administration and for 4 days afterAs given in this study (mouse).

    Source sentences

    Summary
    Both T alpha 1 and TP5, injected into mice during cocaine administration and for 4 days after, induced a significant recovery of the response to SRBC.
    1 context sentence
    Summary · context
    The effects of thymosin alpha 1 (T alpha 1) and thymopentin (TP5) on the cocaine-induced impairment of the primary antibody response to sheep red blood cells (SRBC) was studied.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with cocaine-induced impairment, thymosin alpha‑1 and thymopentin showed no great difference in overall efficacy.

    In plain wordsIn mice whose immune response was weakened by cocaine, thymosin alpha‑1 worked about as well as thymopentin.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeEfficacy versus thymopentin
    Study

    mousen: not reported in source

    Mice with cocaine-induced impairment of the primary antibody response to SRBC
    Comparator
    Thymopentin
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · During cocaine administration and for 4 days afterAs given in this study (mouse).

    Source sentences

    Summary
    Our experiments did not show any great differences in the overall efficacy of the two drugs, although they showed quite a different dose-response effect.
    1 context sentence
    Summary · context
    The effects of thymosin alpha 1 (T alpha 1) and thymopentin (TP5) on the cocaine-induced impairment of the primary antibody response to sheep red blood cells (SRBC) was studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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