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Study · In vitro (cells) · sheep · 1993

3 results

Hypothalamic peptide regulation of ACTH secretion from sheep pituitary.

Kemppainen RJ, Clark TP, Sartin JL, Zerbe CA

The American journal of physiology1 Oct 1993Cited by 13 (Europe PMC)

PMID8238455 (opens in a new tab)DOI10.1152/ajpregu.1993.265.4.r840 (opens in a new tab)PepBankPUB-08238455
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured sheep anterior pituitary cells, oxytocin increased ACTH secretion.

    In plain wordsIn sheep pituitary cells, oxytocin raised ACTH release.

    Peptide
    Oxytocin
    Outcome
    IncreaseACTH secretion
    Study

    sheepn: not reported in source

    cultured sheep anterior pituitary cells
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Incubation of cells with CRF, AVP, and OT, but not ANG II, was associated with increased ACTH secretion.
    1 context sentence
    Summary · context
    The relative abilities of the hypothalamic peptides corticotropin-releasing factor (CRF), arginine vasopressin (AVP), oxytocin (OT), and angiotensin II (ANG II) to stimulate adrenocorticotropic hormone (ACTH) secretion from cultured sheep anterior pituitary cells were studied.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured sheep anterior pituitary cells, the minimally effective dose of oxytocin for ACTH secretion was 10 nM.

    In plain wordsIn sheep pituitary cells, the lowest oxytocin dose that raised ACTH release was 10 nM.

    Peptide
    Oxytocin
    Outcome
    IncreaseMinimally effective dose for ACTH secretion
    Study

    sheepn: not reported in source

    cultured sheep anterior pituitary cells
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    10 nMAs given in this study (sheep).

    Measurements

    minimally effective dose
    10 nM
    ACTH secretion

    Source sentences

    Summary
    The minimally effective dose of OT was 10 nM
    1 context sentence
    Summary · context
    The relative abilities of the hypothalamic peptides corticotropin-releasing factor (CRF), arginine vasopressin (AVP), oxytocin (OT), and angiotensin II (ANG II) to stimulate adrenocorticotropic hormone (ACTH) secretion from cultured sheep anterior pituitary cells were studied.
  3. 03LabIn vitro (cells)Activity measurement

    In cultured sheep anterior pituitary cells, oxytocin doses above 10 nM gave ACTH responses similar to those after arginine vasopressin.

    In plain wordsIn sheep pituitary cells, higher oxytocin doses raised ACTH release about as much as vasopressin did.

    Peptide
    Oxytocin
    Outcome
    Not applicableACTH secretory response at doses above 10 nM compared with AVP
    Study

    sheepn: not reported in source

    cultured sheep anterior pituitary cells
    Comparator
    Arginine vasopressin
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    above 10 nMAs given in this study (sheep).

    Source sentences

    Summary
    greater doses of this peptide resulted in ACTH secretory responses similar to those measured after addition of AVP.
    1 context sentence
    Summary · context
    The relative abilities of the hypothalamic peptides corticotropin-releasing factor (CRF), arginine vasopressin (AVP), oxytocin (OT), and angiotensin II (ANG II) to stimulate adrenocorticotropic hormone (ACTH) secretion from cultured sheep anterior pituitary cells were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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